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A phylogeny shows evolutionary relationships of hCoV-19 (or SARS-CoV-2) viruses from the ongoing novel coronavirus COVID-19 pandemic
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Lisa Scheifele onto Coronavirus @ 3:07 pm on 05 Apr 2020
Video from Nova on how the tests work.
Lisa Scheifele onto Coronavirus @ 3:27 pm on 04 Apr 2020
The homework assigned through the files follows a presentation on qPCR. The goal of the assignment is for the students to get primer pairs that do not bind to human DNA or the SARS Coronavirus that caused the 2003 epidemic. It is easy to assess through Primer-Blast or the UCSC in-silico PCR tool (links provided above).
Nik Tsotakos onto Coronavirus @ 10:13 am on 02 Apr 2020
This is an activity that took place in an Advanced Genetics class that meets in a computer lab. The activity aims to construct a phylogenetic tree of different Coronaviruses, including a few strains of SARS-CoV2. The sequences were pulled from the Virus Pathogen Database and Genbank. Since the activity initially took place in mid-February, there are a lot more available sequences in the databases, while at least one of the sequences included has been retracted. The homework in the end is another application of the skillset the students acquired through the activity, and can be modified based on the course's objectives.
Nik Tsotakos onto Coronavirus @ 10:03 am on 02 Apr 2020
Lisa Scheifele onto Coronavirus @ 10:35 pm on 27 Mar 2020
Use of synthetic biology to improve the signal-to-noise ratio in coronavirus diagnostics
Lisa Scheifele onto Coronavirus @ 10:31 pm on 27 Mar 2020
Perspectives article discussing important ethical dilemmas in developing coronavirus vaccines.
Lisa Scheifele onto Coronavirus @ 10:26 pm on 27 Mar 2020
Use of synthetic genomics to clone and synthesize the Covid-19 genome. Preprint from Biorxiv.
Lisa Scheifele onto Coronavirus @ 10:15 pm on 27 Mar 2020
Review article on different potential treatment strategies and where in the viral life cycle intervention is possible.
Lisa Scheifele onto Coronavirus @ 10:10 pm on 27 Mar 2020
Using synthetic biology, the authors engineered the spike protein (S) from an animal strain and used in vitro evolution to understand how it could adapt to replicate well in human cells.
Lisa Scheifele onto Coronavirus @ 10:06 pm on 27 Mar 2020
One of the first papers sequencing Covid-19 viruses and identifying its potential animal source
Lisa Scheifele onto Coronavirus @ 9:59 pm on 27 Mar 2020
Paper investigating the development of safe and effective vaccines against SARS coronavirus
Lisa Scheifele onto Coronavirus @ 9:56 pm on 27 Mar 2020
Lisa Scheifele onto Coronavirus @ 9:52 pm on 27 Mar 2020
A video from PBS's It's Okay to Be Smart explaining the spread of coronaviruses, social distancing, and what it means to "flatten the curve"
Lisa Scheifele onto Coronavirus @ 9:46 pm on 27 Mar 2020
Highly useful explainer video on exponential growth and its contribution to epidemics
Lisa Scheifele onto Coronavirus @ 9:42 pm on 27 Mar 2020
Accurate answers to common questions about coronavirus
Lisa Scheifele onto Coronavirus @ 9:39 pm on 27 Mar 2020
Improved methods to detect multiple respiratory viruses with one very specific assay
Lisa Scheifele onto Coronavirus @ 9:35 pm on 27 Mar 2020