CourseSource: Resources

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Cell Signaling Pathways - a Case Study Approach

Signaling and gene expression are fundamental to cell biology and developmental biology. Although these topics are highly interrelated, they typically appear in separate units in a course. We use a series of short problem-based learning exercises...

Courses: Cell Biology Developmental Biology

signal transductiongene expressionCell communicationgenetic disordersregulation of enzyme activity

Essay

1477

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206

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The Impact of Diet and Antibiotics on the Gut Microbiome: Distance Education Variant

The goal of this article is to describe a variation of an active learning exercise that was previously published by the same author under a similar title. The variation describes modifications instructors can use to make the exercise suitable for...

Courses: Biochemistry and Molecular Biology Microbiology

microbiomenutritionbacterial metabolitesgut bacteriahost response

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7965

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397

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Investigating Cell Signaling with Gene Expression Datasets

Modern molecular biology is a data- and computationally-intensive field with few instructional resources for introducing undergraduate students to the requisite skills and techniques for analyzing large data sets. This Lesson helps students: (i)...

Courses: Biochemistry and Molecular Biology Cell Biology

genomicstranscriptionsignaling

Lesson

2125

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236

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The impact of diet and antibiotics on the gut microbiome

The goal of this article is to describe an active learning exercise that can be used in a variety of advanced microbiology courses, including bacterial physiology, ecology, or systems biology. The gut microbiome is a multi-species bacterial...

Courses: Microbiology

microbiomeenvironmental controlhost responsemetabolites

Lesson

2405

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498

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Translating Co-Translational Translocation

Understanding the process of proteins targeting to specific locations within a cell is a fundamental part of cell biology. Synthesis of proteins by co-translational translocation, which also determines the resulting protein topology, is a complex...

Courses: Cell Biology

Topologyco-translational translocationendoplasmic reticulumprotease protection assaysecretory proteinssignal sequencetransmembrane proteins

Lesson

991

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182

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From Cre/LoxP to Fate Maps: Inclusive and Equitable Approaches for Engaging Developmental Biology Students in Experimental Design

Engaging first generation underrepresented minority students in the process of inquiry in developmental biology is important to increase diversity in future graduate STEM education. One important challenge is how we design curricula to foster...

Courses: Developmental Biology

experimental designC. elegansCre/LoxPFate mapheart developmentheart regenerationmousereporter constructzebrafish

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244

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21

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Protein Import Into the ER: Understanding Experimental Methods for Old and New Cellular Discoveries

Process Oriented Guided Inquiry Learning (POGIL) is an effective approach for group work in STEM courses. POGIL-style lessons foster active learning because they require students to communicate and co-construct knowledge to solve problems. Here,...

Courses: Cell Biology Science Process Skills

Necessary and sufficientsignal sequenceProtein SynthesistrafficER importTranslocation

Lesson

2666

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627

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Learning About Protein Localization: A Lesson for Analyzing Figures in a Scientific Publication

In order to function correctly, proteins must be localized to a specific subcellular location. We have designed this lesson to use data from the primary literature to teach students about the mechanisms cells use to direct proteins to the...

Courses: Cell Biology Science Process Skills

colocalizationimmunofluorescenceProtein localizationsignal sequencessubcellular fractionationwestern blotting

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355

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Squirrels in Space: Using Radio Telemetry to Explore the Space Use and Movement of Sciurid Rodents

Biotelemetry is used by researchers to track the interactions of animals with each other and the environment. While advancing technology has led to the development of numerous biotelemetry tools, radio telemetry remains the most common method for...

Courses: Ecology Ecology

DispersalHabitat selectionHome rangeSquirrel-Net

Lesson

1151

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165

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Using Musical Instruments to Model Negative Feedback in the Hypothalamo-Pituitary-Target Gland Axes

Homeostasis and negative feedback are crucial, yet difficult, concepts for undergraduates, particularly in the context of the hypothalamo-pituitary axes. This interactive activity was designed to (1) reveal how negative feedback can restore...

Courses: Anatomy-Physiology

cell-cell communicationhomeostasisnegative feedback

Lesson

2455

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159

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What's in this? Students Deliberate on Endocrine Disrupting Chemicals Found in Everyday Healthcare Items to Build Democratic Skills

In helping our students become informed and active members of society, it is necessary that they develop certain skills that will empower them to improve their community and governance. These skills include communication, collaboration, and...

Courses: Anatomy-Physiology Cell Biology Developmental Biology Introductory Biology Science Process Skills

cellEndocrinehormones

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84

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Responsible and Ethical Conduct of Research: Instruction on Plagiarism

Helping students understand where they should provide citations in research manuscripts is an essential aspect of training them in the responsible and ethical conduct of research. This Lesson comprises about 35 minutes of in-class work to help...

Courses: Science Process Skills

citationwritingethicsplagiarismparaphrasequote

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545

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Investigating the Function of a Transport Protein: Where is ABCB6 Located in Human Cells?

One of the challenges of teaching Cell Biology is helping students understand important research methods used to study cells. The goal of understanding cell biology methods is especially challenging in courses without a laboratory...

Courses: Cell Biology

ABC transporter familyDifferential centrifugationImmunoblottingImmunofluorescence assayProtein localizationPurifying organellesSDS-PAGE

Lesson

1766

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226

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Using a Sequential Interpretation of Data in Envelopes (SIDE) approach to identify a mystery TRP channel

This lesson sought to engage students in data interpretation and to encourage critical thinking about neurophysiology in the context of temperature sensation. A family of receptors called Transient Receptor Potential (TRP) channels are activated...

Courses: Anatomy-Physiology Cell Biology Neurobiology

Cell communicationChannel specificity and activationLimitations of tools of Cell BiologyNeuronal Signaling

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Design Your Own Flow Cytometry Experiment: A Four-Week Inquiry Laboratory

Due to its importance to the field, flow cytometry should be one of the hallmark methods a student learns in the lab portion of an undergraduate immunology course. Flow cytometry is a classic lab technique utilized within immunology and molecular...

Courses: Immunology

Immunologyexperimental designFlow cytometryMice

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Why do Some People Inherit a Predisposition to Cancer? A small group activity on cancer genetics

Before undergraduate students take a genetics course they generally know cancer has a genetic basis and involves the proliferation of cells; however, many are uncertain about why only a subset of people have a predisposition to cancer and how that...

Courses: Genetics Science Process Skills

cancerInheritance patternsProbability calculationProto-oncogeneTumor Suppressor Gene

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907

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A Structured Inquiry-Based Module for the Undergraduate Cell Biology Laboratory That Teaches Fundamental Concepts of Cell Differentiation

Pedagogical research in science education has shown that students effectively learn science by doing science. As a result, there is increased interest in bringing research-like experiences into the classroom, particularly for laboratory courses....

Courses: Cell Biology

fluorescence microscopygene expressionpolymerase chain reactionCell Structurecell culturewestern blottingdifferentiationreverse transcription

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Teaching Advanced Concepts in Regulation of the Lac Operon With Modeling and Simulation

Success in biochemistry and other life science courses requires that students understand important biological concepts. One of these concepts is how gene regulation ensures that homeostasis is maintained in an organism. The lac operon is a...

Courses: Biochemistry and Molecular Biology

gene regulationinducible operonProkaryotic cellPhosphoenolpyruvate transferase system (PTS)

Lesson

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The Leaky Neuron: Understanding synaptic integration using an analogy involving leaky cups

Students have difficulty understanding synaptic integration in neural circuits, and how spatial and temporal summation combine in a target neuron to reach threshold. This Lesson uses small cups of water to represent excitatory postsynaptic...

Courses: Neurobiology

neuron physiologyspatial summationsynaptic integrationtemporal summationthreshold

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Cell Signaling Pathways - a Case Study Approach

The Impact of Diet and Antibiotics on the Gut Microbiome: Distance Education Variant

Investigating Cell Signaling with Gene Expression Datasets

The impact of diet and antibiotics on the gut microbiome

Translating Co-Translational Translocation

From Cre/LoxP to Fate Maps: Inclusive and Equitable Approaches for Engaging Developmental Biology Students in Experimental Design

Protein Import Into the ER: Understanding Experimental Methods for Old and New Cellular Discoveries

Learning About Protein Localization: A Lesson for Analyzing Figures in a Scientific Publication

Squirrels in Space: Using Radio Telemetry to Explore the Space Use and Movement of Sciurid Rodents

Using Musical Instruments to Model Negative Feedback in the Hypothalamo-Pituitary-Target Gland Axes

What's in this? Students Deliberate on Endocrine Disrupting Chemicals Found in Everyday Healthcare Items to Build Democratic Skills

Responsible and Ethical Conduct of Research: Instruction on Plagiarism

Investigating the Function of a Transport Protein: Where is ABCB6 Located in Human Cells?

Using a Sequential Interpretation of Data in Envelopes (SIDE) approach to identify a mystery TRP channel

Design Your Own Flow Cytometry Experiment: A Four-Week Inquiry Laboratory

Why do Some People Inherit a Predisposition to Cancer? A small group activity on cancer genetics

A Structured Inquiry-Based Module for the Undergraduate Cell Biology Laboratory That Teaches Fundamental Concepts of Cell Differentiation

Teaching Advanced Concepts in Regulation of the Lac Operon With Modeling and Simulation

The Leaky Neuron: Understanding synaptic integration using an analogy involving leaky cups

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