CourseSource: Resources

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Splicing it Together: Using Primary Data to Explore RNA Splicing and Gene Expression in Large-Lecture Introductory Biology

At the heart of scientific ways of knowing is the systematic collection and analysis of data, which is then used to propose an explanation of how the world works. In this two-day module, students in a large-lecture course are immersed in a...

Courses: Biochemistry and Molecular Biology Cell Biology Genetics Introductory Biology

gene regulationtranscriptiongene expressioncentral dogmarepressoralternative splicingmRNA processingActivatorTranscription factors

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7669

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1462

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An undergraduate bioinformatics curriculum that teaches eukaryotic gene structure

Gene structure, transcription, translation, and alternative splicing are challenging concepts for many undergraduates studying biology. These topics are typically covered in a traditional lecture environment, but students often fail to master and...

Courses: Biochemistry and Molecular Biology Bioinformatics Genetics

bioinformaticsGenome BrowsergenomicsRNAseqsplicingComputer ModelGene Structure

Lesson

7963

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397

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0

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Investigating Cell Signaling with Gene Expression Datasets

Modern molecular biology is a data- and computationally-intensive field with few instructional resources for introducing undergraduate students to the requisite skills and techniques for analyzing large data sets. This Lesson helps students: (i)...

Courses: Biochemistry and Molecular Biology Cell Biology

genomicstranscriptionsignaling

Lesson

1731

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422

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0

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How to Find a Gene: Retrieving Information From Gene Databases

A strong understanding of distinct gene components and the ability to retrieve relevant information from gene databases are necessary to answer a diverse set of biological questions. However, often there is a considerable gap between...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Genetics Introductory Biology

NCBItranscriptiontranslationGene StructureGene databasesEnsembl

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432

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66

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0

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The Science and Ethics of Gene Drives: An Active Learning Lesson in Genetics

Coursework connecting biology to socially relevant issues and ethical questions can help students think about biology in interdisciplinary terms. Gene drives represent one topic involving both advanced biology concepts and societally relevant...

Courses: Genetics

bioethicsCRISPR/Cas9Genetic modificationGene drives

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2992

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549

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2

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A Fun Introductory Command Line Lesson: Next Generation Sequencing Quality Analysis with Emoji!

Radical innovations in DNA sequencing technology over the past decade have created an increased need for computational bioinformatics analyses in the 21st century STEM workforce. Recent evidence however demonstrates that there are significant...

Courses: Bioinformatics

bioinformaticsgenomicscodingJupyter notebookcommand lineCyVersescriptingnext generation sequencing analysis

Lesson

3686

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200

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0

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Three Research-Based Quantitative Reasoning Modules for Introductory Organismal Biology Laboratories

We have designed three laboratory modules for an introductory organismal biology course with an emphasis on quantitative reasoning and data analysis skills. Module 1 tests for dimorphism in crayfish chelae using a paired statistical design. Module...

Courses: Introductory Biology Science Process Skills

allometryplantsAnatomytranspirationdimorphisminvertebrate biologyarthropodsplatyhelminths

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2130

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665

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Sequence Similarity: An inquiry based and "under the hood" approach for incorporating molecular sequence alignment in introductory undergraduate biology courses

Introductory bioinformatics exercises often walk students through the use of computational tools, but often provide little understanding of what a computational tool does "under the hood." A solid understanding of how a bioinformatics...

Courses: Biochemistry and Molecular Biology Bioinformatics Introductory Biology

BLASTmultiple sequence alignmentsequence similarityphylogramZika virusAlgorithmScoring Matrix

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2561

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641

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Follow the Sulfur: Using Yeast Mutants to Study a Metabolic Pathway

Students are frequently overwhelmed by the complexity of metabolic pathways and they think they have "learned" the pathway when they have memorized the individual reactions. This laboratory lesson helps students to understand the...

Courses: Biochemistry and Molecular Biology Genetics Introductory Biology Microbiology Science Process Skills

SelectionyeastMetabolismcysteinemediamethioninemutantPathwaysulfur

Teaching Tools and Strategies

2825

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394

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The Flight Physics Concept Inventory: Reliably Evaluating Aerodynamic Lift, Drag and Associated (Naïve) Concepts of Flight in Class and In-Game

Students often struggle to transfer conceptual understanding from isolated instruction to a coherent mental model. This is especially true for the context of flight physics, fluid dynamics, or the concepts of aerodynamic lift, drag, stall, center...

Courses: Introductory Physics: Calculus-Based

active learninggamificationmisconceptionsaerodynamicsfluid dynamicsResearch-based assessment instrumentConceptual SurveyPRE-/POST-test

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1370

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124

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0

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Glycolysis Can Be Fun: Rediscovering Glycolysis as a Problem-Solving Introduction to Metabolism

A thorough understanding of glycolysis forms a foundation for students to analyze subsequent topics in metabolism, a core competency recognized by multiple national societies for biology and biochemistry. However, when confronted with the names of...

Courses: Biochemistry and Molecular Biology Cell Biology

Problem based learningguided inquiryenzymesGlycolysisMetabolismFermentationchemical reactionsCard sorting activityCofactors

Lesson

3345

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617

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Predicting and classifying effects of insertion and deletion mutations on protein coding regions

Mutations in genes can affect the encoded proteins in multiple ways, and some of these effects are counterintuitive. As for any other knowledge, students must create their own deep understanding of the Central Dogma. Students may not develop this...

Courses: Bioinformatics Genetics Science Process Skills

mutationcentral dogmatranslationframeshift

Lesson

3026

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550

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0

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An Original-Design Board Game to Increase Student Comprehension of Cellular Respiration Pathways

Cellular respiration is a daunting topic for many students in introductory biology courses. Students are challenged at conceptual and factual levels, since instruction covers multiple metabolic pathways occurring across different cellular...

Courses: Biochemistry and Molecular Biology Cell Biology Introductory Biology Science Process Skills

GlycolysisCellular RespirationFermentationKrebs CycleOxidative phosphorylationpyruvate oxidation

Lesson

4908

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495

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0

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Does Organelle Shape Matter?: Exploring Patterns in Cell Shape and Structure with High-Throughput (HT) Imaging

Organelle structure has been studied and visualized for decades; however, publicly available databases that use improved high-throughput microscopy of gene-edited cell lines have recently revolutionized the amount and quality of information now...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Genetics Science Process Skills

modelingcase studymicroscopystructureOrganellesHigh-throughput (HT)Endoplasmic Reticulum (ER)Fluorescent microscopyHuman Cell Biology

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1693

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494

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0

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Sex-specific differences in Meiosis: Real-world applications

In traditional classrooms, students are typically presented with facts that they are asked to memorize and recall during an exam. The rapid explosion of available scientific facts in recent years has made this model of teaching...

Courses: Cell Biology Genetics Science Process Skills

meiosisReproductionAneuploidyGameteNon-disjunctionOocyteSpermTrisomy

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2642

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576

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Linking Genotype to Phenotype: The Effect of a Mutation in Gibberellic Acid Production on Plant Germination

Basic concepts in genetics and plant development are often taught in lecture courses without a lab component. This approach provides students with the content knowledge, but fails to make connections to research opportunities and real-world...

Courses: Cell Biology Developmental Biology Genetics Introductory Biology Plant Biology

geneticsdevelopmentmutationgerminationplantmodel organismGenotype/PhenotypeHormoneSeed

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9401

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562

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Manuscript 101: A Data-Driven Writing Exercise for Beginning Scientists

Learning to write a scientific manuscript is one of the most important and rewarding scientific training experiences, yet most young scientists only embark on this experience relatively late in graduate school after gathering sufficient data in...

Courses: Bioinformatics Cell Biology Developmental Biology Genetics Microbiology Science Process Skills

geneticsanimaldevelopmentcompetitionbacterial

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2092

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288

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Assessing in vivo Antimicrobial Activity Through the Analysis of Galleria mellonella Kaplan-Meier Plots

Antimicrobials and their use in the treatment of bacterial infections are a fundamental lesson in all microbiology courses. Typically, cultivation-based methods are used to teach students about antimicrobial testing. A complementary approach...

Courses: Microbiology

Antimicrobial TestingAntimicrobialsInvertebrate animal models

Lesson

1481

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435

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Using Images of Foraging Leaf-Cutter Ants to Teach Linear Regression

This lesson offers students a realistic, open-inquiry research experience, even when lab or field research is not possible. We first introduce students to leaf-cutter ants and how they forage. Then we provide images and videos of foraging...

Courses: Ecology Ecology Introductory Biology Science Process Skills

linear regressionexperimental designPlant-insect interactionsSymbiosisForaging behavior

Lesson

3370

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916

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Assessing Urban Biodiversity With the eBird Citizen Science Project: A Course-Based Undergraduate Research Experience (CURE) Module

The eBird citizen science module takes advantage of technology tools and online resources developed by the Cornell Laboratory of Ornithology (http://ebird.org) to achieve several learning objectives embedded in a semester-long upper-level biology...

Courses: Ecology Ecology Science Process Skills

datacitizen sciencecommunityBiodiversitySpecieshypothesishabitat

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Splicing it Together: Using Primary Data to Explore RNA Splicing and Gene Expression in Large-Lecture Introductory Biology

An undergraduate bioinformatics curriculum that teaches eukaryotic gene structure

Investigating Cell Signaling with Gene Expression Datasets

How to Find a Gene: Retrieving Information From Gene Databases

The Science and Ethics of Gene Drives: An Active Learning Lesson in Genetics

A Fun Introductory Command Line Lesson: Next Generation Sequencing Quality Analysis with Emoji!

Three Research-Based Quantitative Reasoning Modules for Introductory Organismal Biology Laboratories

Sequence Similarity: An inquiry based and "under the hood" approach for incorporating molecular sequence alignment in introductory undergraduate biology courses

Follow the Sulfur: Using Yeast Mutants to Study a Metabolic Pathway

The Flight Physics Concept Inventory: Reliably Evaluating Aerodynamic Lift, Drag and Associated (Naïve) Concepts of Flight in Class and In-Game

Glycolysis Can Be Fun: Rediscovering Glycolysis as a Problem-Solving Introduction to Metabolism

Predicting and classifying effects of insertion and deletion mutations on protein coding regions

An Original-Design Board Game to Increase Student Comprehension of Cellular Respiration Pathways

Does Organelle Shape Matter?: Exploring Patterns in Cell Shape and Structure with High-Throughput (HT) Imaging

Sex-specific differences in Meiosis: Real-world applications

Linking Genotype to Phenotype: The Effect of a Mutation in Gibberellic Acid Production on Plant Germination

Manuscript 101: A Data-Driven Writing Exercise for Beginning Scientists

Assessing in vivo Antimicrobial Activity Through the Analysis of Galleria mellonella Kaplan-Meier Plots

Using Images of Foraging Leaf-Cutter Ants to Teach Linear Regression

Assessing Urban Biodiversity With the eBird Citizen Science Project: A Course-Based Undergraduate Research Experience (CURE) Module

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