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    Using a Primary Cell Culture Model to Study the Neural Extracellular Matrix
    The extracellular matrix (ECM) provides structural support to cells, but also has key roles in mediating cell adhesion, cell signaling, and differentiation. While this topic is discussed in the lecture setting, it is not heavily studied in...

    Courses: Cell BiologyCell Biology NeurobiologyNeurobiology

    Neural extracellular matrixPerineuronal netPrimary neuronal culture
    Lesson
    12429

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    1882

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    2

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    A virtual laboratory on cell division using a publicly-available image database
    Cell division is a key concept in cell biology. While there are many popular activities to teach students the stages of mitosis, most make use of simple schematics, cartoons, or textbook diagrams. Others engage students in acting out the stages,...

    Courses: Cell BiologyCell Biology Science Process SkillsScience Process Skills

    image analysismicroscopymitosisCellular Processes
    Lesson
    915

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    58

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    0

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    A Structured Inquiry-Based Module for the Undergraduate Cell Biology Laboratory That Teaches Fundamental Concepts of Cell Differentiation
    Pedagogical research in science education has shown that students effectively learn science by doing science. As a result, there is increased interest in bringing research-like experiences into the classroom, particularly for laboratory courses....

    Courses: Cell BiologyCell Biology

    fluorescence microscopygene expressionpolymerase chain reactionCell Structurecell culturewestern blottingdifferentiationreverse transcription
    Lesson
    2380

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    474

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    From Dirt to Streptomyces DNA
    The purpose of this semester-long Lesson is to give students an authentic, course-based undergraduate research experience during which they learn basic and advanced microbiological and molecular biology techniques. This project begins with the...

    Courses: MicrobiologyMicrobiology

    MetabolismAntibiotic productionrRNA genesSecondary metabolitesStreptomyces
    Essay
    1433

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    135

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    0

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    Going Remote: An Online Adaptation to Using a Primary Cell Culture Model to Study the Neural Extracellular Matrix
    In light of the COVID-19 pandemic, instructors have modified materials to transition to a remote learning platform. The challenge for science instructors has been to design lab exercises that incorporate both active and experiential learning. In...

    Courses: Cell BiologyCell Biology NeurobiologyNeurobiology

    remote learningExtracellular matrixNeural extracellular matrixPerineuronal net
    Lesson
    3320

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    550

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    0

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    A Student-Led Hearing on the Use of HeLa Cells in Research
    In this role-playing case study, students will learn about the HeLa cell line and its origins while examining multiple perspectives surrounding the cell line and its uses. The goal of this case study is for students to use guided questions to...

    Courses: Cell BiologyCell Biology Science Process SkillsScience Process Skills

    bioethicsscience policycell culturedebateHeLa cellsinformed consentrole playsocial justice issues
    Lesson
    3576

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    265

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    SEAS CURE: Exploring Coral Biology Across Scales
    Complex biological concepts (like symbiosis and coral biology) that span multiple scales and cross disciplinary boundaries are often difficult for students to understand. This complexity is compounded by the challenges inherent to teaching and...

    Courses: Anatomy-PhysiologyAnatomy-Physiology Cell BiologyCell Biology EcologyEcology Introductory BiologyIntroductory Biology Science Process SkillsScience Process Skills

    microscopyAnatomySymbiosisMetabolismbleachinginvertebratedinoflagellate
    Lesson
    2580

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    645

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    Follow the Sulfur: Using Yeast Mutants to Study a Metabolic Pathway
    Students are frequently overwhelmed by the complexity of metabolic pathways and they think they have "learned" the pathway when they have memorized the individual reactions.  This laboratory lesson helps students to understand the...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology GeneticsGenetics Introductory BiologyIntroductory Biology MicrobiologyMicrobiology Science Process SkillsScience Process Skills

    SelectionyeastMetabolismcysteinemediamethioninemutantPathwaysulfur
    Lesson
    2118

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    288

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    0

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    Assessing in vivo Antimicrobial Activity Through the Analysis of Galleria mellonella Kaplan-Meier Plots
    Antimicrobials and their use in the treatment of bacterial infections are a fundamental lesson in all microbiology courses. Typically, cultivation-based methods are used to teach students about antimicrobial testing. A complementary approach...

    Courses: MicrobiologyMicrobiology

    Antimicrobial TestingAntimicrobialsInvertebrate animal models
    Lesson
    1666

    views

    317

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    0

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    Differential Gene Expression during Xenopus laevis Development
    In Developmental Biology classes, students are challenged with understanding how differential gene expression guides embryonic development. It can be difficult for students to realize that genes need to be turned on or off at the right time and...

    Courses: Developmental BiologyDevelopmental Biology

    gene expressionXenopusearly developmentembryofertilizationin situ hybridization
    Lesson
    3412

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    1184

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    0

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    CRISPR/Cas9 in yeast: a multi-week laboratory exercise for undergraduate students
    Providing undergraduate life-science students with a course-based research experience that utilizes cutting-edge technology, is tractable for students, and is manageable as an instructor is a challenge. Here, I describe a multi-week lesson plan...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology BioinformaticsBioinformatics GeneticsGenetics MicrobiologyMicrobiology Science Process SkillsScience Process Skills

    bioinformaticsPCRphenotypingCRISPR/Cas9gene editingcloningGenotypingRestriction enzyme
    Lesson
    1537

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    194

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    0

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    Hands-On, Hands-Off: The Community College Genomics (ComGen) Course-Based Undergraduate Research Experience
    Science is a process of discovery where failure is inherent and iteration is necessary, yet instructors often teach the scientific process as if it is a controlled, highly supervised, confirmatory practice of following directions to get a known...

    Courses: Cell BiologyCell Biology GeneticsGenetics

    geneticssequencingDNAbacterium
    Lesson
    2210

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    461

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    Antibiotic Resistance Genes Detection in Environmental Samples
    Our aim is to provide an authentic research experience for undergraduate students in a variety of biology courses through collaboration between a four-year university and a community college. This lab series teaches transferable and universal...

    Courses: Introductory BiologyIntroductory Biology MicrobiologyMicrobiology Science Process SkillsScience Process Skills

    geneticsenvironmentmicrobiologyUndergraduateantibiotic-resistancePCRgel electrophoresisauthentic inquiry
    Lesson
    1816

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    191

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    0

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    Inexpensive Cell Migration Inquiry Lab using Zebrafish
    Cell migration is an important and interesting topic that has the potential to engage students in cell biology by its intrinsically active nature. However, most ways to investigate cell migration require expensive equipment not typically available...

    Courses: Cell BiologyCell Biology Science Process SkillsScience Process Skills

    CytoskeletonCell migrationmodel organisms
    Lesson
    4216

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    672

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    Design Your Own Flow Cytometry Experiment: A Four-Week Inquiry Laboratory
    Due to its importance to the field, flow cytometry should be one of the hallmark methods a student learns in the lab portion of an undergraduate immunology course. Flow cytometry is a classic lab technique utilized within immunology and molecular...

    Courses: ImmunologyImmunology

    Immunologyexperimental designFlow cytometryMice
    Teaching Tools and Strategies
    3352

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    131

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    Enhancing the Microscopy Skills of Non-Science Majors and Nursing Microbiology Students: Promoting the Practice of Observing Multiple Fields of View Using Blood Smear Slides
    One of the challenges in teaching microscopy is having students scan multiple fields of view at high power magnification. Many times, students will feel this unnecessary, especially when presented with slides that show only one structure or a...

    Courses: Introductory BiologyIntroductory Biology MicrobiologyMicrobiology

    Microscopy SkillsBlood SmearsBlood Disorders
    Lesson
    3545

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    1321

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    0

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    A CRISPR/Cas Guide RNA Design In Silico Activity
    CRISPR biotechnologies inspired by the Clustered Regularly Interspaced Short Palindromic Repeat RNA-guided nuclease adaptive bacterial immune system have revolutionized biology research and become ubiquitous tools for hypothesis and...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology BioinformaticsBioinformatics Cell BiologyCell Biology GeneticsGenetics

    bioinformaticsgene expressiongenetic basis of diseaseCRISPR/Cas9genetic engineeringin silico
    Lesson
    1279

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    71

    downloads

    0

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    Defining Life: Exploring Creativity, Scientific Discovery, and Biology Core Concepts in a Disciplinary First-Year Seminar
    This unit, Defining Life, engages students in thinking like scientists, applying creativity to science, and learning biology core concepts as they explore the defining characteristics of life. This unit provides an example of a curriculum designed...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Cell BiologyCell Biology EvolutionEvolution GeneticsGenetics Introductory BiologyIntroductory Biology MicrobiologyMicrobiology Science Process SkillsScience Process Skills

    Evolutionbiologycellprocess of science
    Lesson
    2022

    views

    575

    downloads

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    Using Undergraduate Molecular Biology Labs to Discover Targets of miRNAs in Humans
    Incorporating authentic research experiences into undergraduate labs, while shown to be particularly effective at engaging and retaining students in STEM majors, can be difficult to accomplish within the constraints of resource availability or...

    Courses: BioinformaticsBioinformatics GeneticsGenetics Science Process SkillsScience Process Skills

    gene regulationmicroRNAsgene expression
    Teaching Tools and Strategies
    2817

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    273

    downloads

    0

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    The Pipeline CURE: An Iterative Approach to Introduce All Students to Research Throughout a Biology Curriculum
    Participation in research provides personal and professional benefits for undergraduates. However, some students face institutional barriers that prevent their entry into research, particularly those from underrepresented groups who may stand to...

    Courses: Developmental BiologyDevelopmental Biology GeneticsGenetics Introductory BiologyIntroductory Biology Science Process SkillsScience Process Skills

    epigeneticsundergraduate researchmendelian inheritanceSelf-EfficacyCUREsnature of scienceResiliencecurriculum strategiesreprogramming