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Single Cell Insights Into Cancer Transcriptomes: A Five-Part Single-Cell RNAseq Case Study Lesson
There is a growing need for integration of “Big Data” into undergraduate biology curricula. Transcriptomics is one venue to examine biology from an informatics perspective. RNA sequencing has largely replaced the use of microarrays for...
bioinformatics cancer transcriptomics high-throughput Data wrangling Single cell RNA sequencingq
Lesson
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97

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A CURE for Salmonella: A Laboratory Course in Pathogen Microbiology and Genomics
Rapid advances in genomics and bioinformatics, the vast amount of data generated by next-generation sequencing, and the penetration of the ‘-omics’ into many areas of biology have created a need for students with hands-on experience...
epidemiology research bioinformatics genomics public health Antibiotic Resistant Bacteria Salmonella DNA sequencing pathogenic bacteria
Lesson
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107

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An undergraduate bioinformatics curriculum that teaches eukaryotic gene structure
Gene structure, transcription, translation, and alternative splicing are challenging concepts for many undergraduates studying biology. These topics are typically covered in a traditional lecture environment, but students often fail to master and...
bioinformatics Genome Browser genomics RNAseq splicing Computer Model Gene Structure
Lesson
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Follow the Sulfur: Using Yeast Mutants to Study a Metabolic Pathway
Students are frequently overwhelmed by the complexity of metabolic pathways and they think they have "learned" the pathway when they have memorized the individual reactions.  This laboratory lesson helps students to understand the...
Selection yeast Metabolism cysteine media methionine mutant Pathway sulfur
Teaching Tools and Strategies
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Drawing flowcharts of lab protocols helps students prepare for biology labs
With the publishing of the Vision and Change report, we know it is best practice to include authentic research experiences in our undergraduate science lab classes. One big challenge in teaching so-called "wet lab" classes is figuring...
laboratory molecular biology Undergraduate protocol flowchart
Lesson
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Fly Exercise: A Simple Experiment to Test the Physiological Effects of Exercise on a Model Organism
Model organisms are commonly used to study and experimentally explore biological processes in ways that are technically or ethically not possible in humans. For this reason, model organisms are an essential component of scientific research and...
exercise enzyme kinetics metabolite concentration model species physical activity
Essay
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The Impact of Diet and Antibiotics on the Gut Microbiome: Distance Education Variant
The goal of this article is to describe a variation of an active learning exercise that was previously published by the same author under a similar title. The variation describes modifications instructors can use to make the exercise suitable for...
microbiome nutrition bacterial metabolites gut bacteria host response
Lesson
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Breaking Bricks: A Hands-On Model of Enzyme Kinetics and Inhibition
Enzyme kinetics and the impacts of inhibitors on the enzyme's maximal velocity and ability to bind substrates are important topics in cell biology and biochemistry. However, these topics can be difficult for students to grasp when instructed...
kinetics Enzyme competitive inhibition
Lesson
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Mapping a Mutation to its Gene: The "Fly Lab" as a Modern Research Experience
Although genetics is an invaluable part of the undergraduate biology curriculum, it can be intimidating to students as well as instructors: Students must reduce their reliance on memorization and dive deep into quantitative analysis, and...
genetics bioinformatics drosophila chi-square analysis complementation mapping mode of inheritance three-point mapping
Lesson
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Unwrapping Enzyme Kinetics
Enzyme rates and kinetics are key components used by biochemists to understand how enzymes function. However, students often find it difficult to understand how these experiments are performed and how they reflect enzyme behavior in solution. The...
kinetics structure-function enzymes catalysis
Lesson
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A CRISPR/Cas Guide RNA Design In Silico Activity
CRISPR biotechnologies inspired by the Clustered Regularly Interspaced Short Palindromic Repeat RNA-guided nuclease adaptive bacterial immune system have revolutionized biology research and become ubiquitous tools for hypothesis and...
bioinformatics gene expression genetic basis of disease CRISPR/Cas9 genetic engineering in silico
Lesson
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Integrating Manipulatives and Animations to Visualize Holliday Junctions
The complex molecular architecture of Holliday junctions is often challenging for undergraduate biochemistry students to conceptualize. In particular, they have difficulty translating from two-dimensional, linear representations shown in textbooks...
dna structure DNA damage DNA recombination Gene crossover Holliday junction
Lesson
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Investigating Gene Expression and Cell Specialization in Axolotl Embryos
The process of cell specialization is critical to the formation and function of tissues in animals and plants. Although gene expression, including the regulation of transcription, is taught in most introductory cell biology courses, the...
development transcription gene expression embryo
Lesson
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To Vaccinate or Not to Vaccinate
To vaccinate or not to vaccinate, that is the question. Much of the recent trend in society against vaccination is that the general population does not understand 1) how vaccines work and 2) how one's vaccination status can influence others....
pathogen ELISA immunity antibody Antigen
Lesson
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The Avocado Lab: An Inquiry-Driven Exploration of an Enzymatic Browning Reaction
Typical biochemistry labs exploring basic enzyme activity rely on costly, time-consuming protein purification and rarely explore enzyme function in situ. Further, complex purification procedures leave little room for novelty in experimental...
enzymes controls enzyme inhibition