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    Does Organelle Shape Matter?: Exploring Patterns in Cell Shape and Structure with High-Throughput (HT) Imaging
    Organelle structure has been studied and visualized for decades; however, publicly available databases that use improved high-throughput microscopy of gene-edited cell lines have recently revolutionized the amount and quality of information now...
    modeling case study microscopy structure Organelles High-throughput (HT) Endoplasmic Reticulum (ER) Fluorescent microscopy Human Cell Biology
    Lesson
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    87

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    Using Bioinformatics and Molecular Visualization to Develop Student Hypotheses in a Malate Dehydrogenase Oriented CURE
    Developing student creativity and ability to develop a testable hypothesis represents a significant challenge in most laboratory courses. This lesson demonstrates how students use facets of molecular evolution and bioinformatics approaches...
    bioinformatics Noncovalent Interactions Enzyme Catalysis Protein Structure/function
    Teaching Tools and Strategies
    625

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    784

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    A 360˚ View of COVID-19
    In March 2020, institutions underwent a massive transition to distance learning as a result of the COVID-19 pandemic. With so little time to devise new materials to maximize learning in the new virtual environment, instructors devised a variety of...
    genetics Immunology Biochemistry bioinformatics molecular evolution public health virus COVID19
    Lesson
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    87

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    Moths and Frogs and E. coli, Oh My!: Agent-based Modeling of Evolutionary Systems
    In evolution classrooms, introducing and reinforcing the idea of genetic drift and random selection can be challenging, as can be reinforcing appropriate mental models of evolution. Agent-based models offer students the opportunity to conduct a...
    modeling Evolution ecology agent-based modeling Genetic Drift environmental science Natural Selection competitive coevolution simulation modeling evolutionary reasoning
    Lesson
    1244

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    780

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    Single Cell Insights Into Cancer Transcriptomes: A Five-Part Single-Cell RNAseq Case Study Lesson
    There is a growing need for integration of “Big Data” into undergraduate biology curricula. Transcriptomics is one venue to examine biology from an informatics perspective. RNA sequencing has largely replaced the use of microarrays for whole...
    bioinformatics cancer transcriptomics high-throughput Data wrangling Single cell RNA sequencingq
    Lesson
    1415

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    688

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    A CURE for <em>Salmonella</em>: A Laboratory Course in Pathogen Microbiology and Genomics
    Rapid advances in genomics and bioinformatics, the vast amount of data generated by next-generation sequencing, and the penetration of the ‘-omics’ into many areas of biology have created a need for students with hands-on experience with...
    epidemiology research bioinformatics genomics public health Antibiotic Resistant Bacteria Salmonella DNA sequencing pathogenic bacteria
    Lesson
    1929

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    594

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    An undergraduate bioinformatics curriculum that teaches eukaryotic gene structure
    Gene structure, transcription, translation, and alternative splicing are challenging concepts for many undergraduates studying biology. These topics are typically covered in a traditional lecture environment, but students often fail to master and...
    bioinformatics Genome Browser genomics RNAseq splicing Computer Model Gene Structure
    Lesson
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    168

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    A Fun Introductory Command Line Lesson: Next Generation Sequencing Quality Analysis with Emoji!
    Radical innovations in DNA sequencing technology over the past decade have created an increased need for computational bioinformatics analyses in the 21st century STEM workforce. Recent evidence however demonstrates that there are significant...

    Courses: BioinformaticsBioinformatics

    bioinformatics genomics coding Jupyter notebook command line CyVerse scripting next generation sequencing analysis
    Lesson
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    322

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    Mapping a Mutation to its Gene: The "Fly Lab" as a Modern Research Experience
    Although genetics is an invaluable part of the undergraduate biology curriculum, it can be intimidating to students as well as instructors: Students must reduce their reliance on memorization and dive deep into quantitative analysis, and...
    genetics bioinformatics drosophila chi-square analysis complementation mapping mode of inheritance three-point mapping
    Lesson
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    321

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    My Dog IS My Homework: Exploring Canine Genetics to Understand Genotype-Phenotype Relationships
    To facilitate understanding of the fundamental genetic concept of the genotype-phenotype relationship in our introductory biology students, we designed an engaging multi-week series of related lessons about canine genetics in which students...
    gel electrophoresis sequence analysis canine genetics deoxyribonucleic acid (DNA) dog coat morphology genotype and phenotype mutations Polymerase chain reaction (PCR) single nucleotide polymorphism (SNP)
    Lesson
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    55

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    Tying it All Together: An Activity to Help Students Connect Course Experiences to Posted Learning Outcomes
    Instructors of undergraduate courses in Biology and other Science, Technology, Engineering, and Mathematics (STEM) disciplines face an ongoing challenge to foster higher-order thinking and learning skills while also developing a sound conceptual...
    metacognition reflection goals Outcomes
    Essay
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    Structuring Courses for Equity
    As instructors, we continually look for new ways to create equitable learning environments and support learning for all students in our courses. Recently, we have explored ways that we can increase structure to better support students. We have...
    Equity metacognition inclusivity course structure
    Teaching Tools and Strategies
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    104

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    DNA Detective: Genotype to Phenotype. A Bioinformatics Workshop for Middle School to College.
    Advances in high-throughput techniques have resulted in a rising demand for scientists with basic bioinformatics skills as well as workshops and curricula that teach students bioinformatics concepts. DNA Detective is a workshop we designed to...
    genetics bioinformatics DNA genotype phenotype gene gene annotation
    Lesson
    197

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    55

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    Training future faculty in 30 minutes a week: A modular framework to provide just-in-time professional development to graduate teaching assistants
    Despite increasing recognition of the need to train the teaching assistants (TAs) teaching the majority of STEM lab sections, very few programs report offering sustained teaching professional development opportunities. Here we present a year-long,...
    professional development TA Training Teaching Assistants
    Lesson
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    222

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    CRISPR/Cas9 in yeast: a multi-week laboratory exercise for undergraduate students
    Providing undergraduate life-science students with a course-based research experience that utilizes cutting-edge technology, is tractable for students, and is manageable as an instructor is a challenge. Here, I describe a multi-week lesson plan...
    bioinformatics PCR phenotyping CRISPR/Cas9 gene editing cloning Genotyping Restriction enzyme