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Splicing it Together: Using Primary Data to Explore RNA Splicing and Gene Expression in Large-Lecture Introductory Biology

At the heart of scientific ways of knowing is the systematic collection and analysis of data, which is then used to propose an explanation of how the world works. In this two-day module, students in a large-lecture course are immersed in a...

Courses: Biochemistry and Molecular Biology Cell Biology Genetics Introductory Biology

gene regulation transcription gene expression central dogma repressor alternative splicing mRNA processing Activator Transcription factors

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244

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15

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Gender and Classroom Participation: A Case for Quantitative Analysis

Teaching statistics to students using authentic research is one way to highlight the transferability and value of the material taught in the class. Below we describe an activity in Statistics for Biological and Health Sciences (STAT2510), an...

Courses: Science Process Skills

statistics gender population Proportion Sample Equality

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1052

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Using Open-Source Bioinformatics and Visualization Tools to Explore the Structure and Function of SARS-CoV-2 Spike Protein

The relationship between protein structure and function is a foundational concept in undergraduate biochemistry. We find this theme is best presented with assignments that encourage exploration and analysis. Here, we share a series of four...

Courses: Biochemistry and Molecular Biology Bioinformatics Science Process Skills

bioinformatics molecular modeling COVID19 protein structure and function UCSF Chimera SARS-CoV-2 spike protein ACE2 receptor

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817

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Learning Quantitative Genetics: Investigation of Genetic Control for Cold Stress Response in Plants

Course-embedded undergraduate research experiences (CUREs) for students have been shown to increase students’ understanding of the process of science, affirm their scientific identity, and improve retention in STEM fields. Despite many CUREs...

Courses: Genetics

data analysis recombination plants quantitative genetics abiotic stress response genetic control of complex traits inheritance of complex traits

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599

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93

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Teaching Advanced Concepts in Regulation of the Lac Operon With Modeling and Simulation

Success in biochemistry and other life science courses requires that students understand important biological concepts. One of these concepts is how gene regulation ensures that homeostasis is maintained in an organism. The lac operon is a...

Courses: Biochemistry and Molecular Biology

gene regulation inducible operon Prokaryotic cell Phosphoenolpyruvate transferase system (PTS)

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2773

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Meiosis Remodeled: Inclusion of New Parts to Poppit Bead Models Enhances Understanding of Meiosis

A long-standing tradition uses strings of poppit beads of different colors to model meiosis, especially to show how segments of paired homologous chromosomes are recombined. Our use of orthodontic latex bands to model cohesion of sister...

Courses: Cell Biology Genetics Introductory Biology

meiosis chiasma formation chromosome recombination

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2313

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Does Organelle Shape Matter?: Exploring Patterns in Cell Shape and Structure with High-Throughput (HT) Imaging

Organelle structure has been studied and visualized for decades; however, publicly available databases that use improved high-throughput microscopy of gene-edited cell lines have recently revolutionized the amount and quality of information now...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Genetics Science Process Skills

modeling case study microscopy structure Organelles High-throughput (HT) Endoplasmic Reticulum (ER) Fluorescent microscopy Human Cell Biology

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1369

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Using Bioinformatics and Molecular Visualization to Develop Student Hypotheses in a Malate Dehydrogenase Oriented CURE

Developing student creativity and ability to develop a testable hypothesis represents a significant challenge in most laboratory courses. This lesson demonstrates how students use facets of molecular evolution and bioinformatics approaches...

Courses: Biochemistry and Molecular Biology Bioinformatics Science Process Skills

bioinformatics Noncovalent Interactions Enzyme Catalysis Protein Structure/function

Teaching Tools and Strategies

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A 360˚ View of COVID-19

In March 2020, institutions underwent a massive transition to distance learning as a result of the COVID-19 pandemic. With so little time to devise new materials to maximize learning in the new virtual environment, instructors devised a variety of...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Evolution Genetics Immunology Introductory Biology Microbiology Science Process Skills

genetics Immunology Biochemistry bioinformatics molecular evolution public health virus COVID19

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668

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207

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Moths and Frogs and E. coli, Oh My!: Agent-based Modeling of Evolutionary Systems

In evolution classrooms, introducing and reinforcing the idea of genetic drift and random selection can be challenging, as can be reinforcing appropriate mental models of evolution. Agent-based models offer students the opportunity to conduct a...

Courses: Bioinformatics Ecology Ecology Evolution Science Process Skills

modeling Evolution ecology agent-based modeling Genetic Drift environmental science Natural Selection competitive coevolution simulation modeling evolutionary reasoning

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894

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How Do Kidneys Make Urine From Blood? Qualitative and Quantitative Approaches to Filtration, Secretion, Reabsorption, and Excretion

The function of the kidneys is to help maintain a constant internal environment (homeostasis) by regulating the volume and chemical composition of the blood. This regulation occurs via three fundamental processes: filtration, secretion, and...

Courses: Anatomy-Physiology Introductory Biology

collecting duct excretion glomerular filtration rate (GFR) nephron tubule reabsorption renal corpuscle section

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637

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It's a Substrate... It's a Protein...No - It's an Enzyme! Teaching Using 3D Serine Protease Physical Modeling Activities to Confront Misconceptions.

Reported misconceptions of enzyme-substrate interactions highlight the necessity for better, targeted instructional tools and assessments. A series of active learning activities with corresponding three-dimensional (3D) physical models were...

Courses: Biochemistry and Molecular Biology

Protein Structure Enzymes-Substrate Interactions Noncovalent Interactions Geometric Complementary Electronics Stereochemistry Serine Proteases

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3034

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1010

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Single Cell Insights Into Cancer Transcriptomes: A Five-Part Single-Cell RNAseq Case Study Lesson

There is a growing need for integration of “Big Data” into undergraduate biology curricula. Transcriptomics is one venue to examine biology from an informatics perspective. RNA sequencing has largely replaced the use of microarrays for whole...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Genetics Introductory Biology

bioinformatics cancer transcriptomics high-throughput Data wrangling Single cell RNA sequencingq

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A CURE for <em>Salmonella</em>: A Laboratory Course in Pathogen Microbiology and Genomics

Rapid advances in genomics and bioinformatics, the vast amount of data generated by next-generation sequencing, and the penetration of the ‘-omics’ into many areas of biology have created a need for students with hands-on experience with...

Courses: Biochemistry and Molecular Biology Bioinformatics Ecology Ecology Microbiology

epidemiology research bioinformatics genomics public health Antibiotic Resistant Bacteria Salmonella DNA sequencing pathogenic bacteria

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3328

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An undergraduate bioinformatics curriculum that teaches eukaryotic gene structure

Gene structure, transcription, translation, and alternative splicing are challenging concepts for many undergraduates studying biology. These topics are typically covered in a traditional lecture environment, but students often fail to master and...

Courses: Biochemistry and Molecular Biology Bioinformatics Genetics

bioinformatics Genome Browser genomics RNAseq splicing Computer Model Gene Structure

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Splicing it Together: Using Primary Data to Explore RNA Splicing and Gene Expression in Large-Lecture Introductory Biology

Gender and Classroom Participation: A Case for Quantitative Analysis

Using Open-Source Bioinformatics and Visualization Tools to Explore the Structure and Function of SARS-CoV-2 Spike Protein

Learning Quantitative Genetics: Investigation of Genetic Control for Cold Stress Response in Plants

Teaching Advanced Concepts in Regulation of the Lac Operon With Modeling and Simulation

Meiosis Remodeled: Inclusion of New Parts to Poppit Bead Models Enhances Understanding of Meiosis

Does Organelle Shape Matter?: Exploring Patterns in Cell Shape and Structure with High-Throughput (HT) Imaging

Using Bioinformatics and Molecular Visualization to Develop Student Hypotheses in a Malate Dehydrogenase Oriented CURE

A 360˚ View of COVID-19

Moths and Frogs and E. coli, Oh My!: Agent-based Modeling of Evolutionary Systems

How Do Kidneys Make Urine From Blood? Qualitative and Quantitative Approaches to Filtration, Secretion, Reabsorption, and Excretion

It's a Substrate... It's a Protein...No - It's an Enzyme! Teaching Using 3D Serine Protease Physical Modeling Activities to Confront Misconceptions.

Single Cell Insights Into Cancer Transcriptomes: A Five-Part Single-Cell RNAseq Case Study Lesson

A CURE for <em>Salmonella</em>: A Laboratory Course in Pathogen Microbiology and Genomics

An undergraduate bioinformatics curriculum that teaches eukaryotic gene structure