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    In silico chromosome mapping: Idiograms
    This workbook allows the user to construct idiograms (haploid or diploid), map sequences onto them, depict chromosome structural mutations, and perform side-by-side comparative analyses of...

    Keywords: InheritancemutationschromosomesidiogramDrosophila melanogaster

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    Two-Species Model
    These two Excel worksheets simulate the population growth of two interacting species. In isolation, each species grows logistically, but interaction effects between species may limit or enhance...

    Keywords: population growthcompetition modelsLotka-Volterra

    146

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    Split Decomp
    This Excel worksheet performs split decomposition on a set of four DNA sequences and their associated amino acid sequences. The user can type in the sequences or paste them in from a text file.

    Keywords: phylogenyDNA sequenceamino acid sequencesplit decomposition

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    Serial Dilutions
    In this Excel workbook, users will enter the original cell concentration and the desired dilution factor (10, 100, and 1000). The program will then calculate the new cell concentration.

    Keywords: concentrationScientific Notationorders of magnitudeserial dilutions

    113

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    Protein Analysis
    This Excel workbook allows the analysis of sample or imported protein sequences. The model can analyze protein sequences up to 500 amino acids long.

    Keywords: Protein sequencehydrophobicity/hydrophilicity

    108

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    Phylogeography Simulator
    This Excel workbook simulates the phylogeography of an asexually reproducing species.

    Keywords: Phylogeographymutation ratesAsexual reproductionspecies dispersal

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    Pharmacokinetics
    This Excel module explores how drugs are processed and absorbed in the human body.

    Keywords: drug metabolismpharmacokinetics

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    Operon
    This Excel workbook models lac operon function in a partial diploid E. coli. The user chooses the bacterial genotype and the sugars present in the surrounding medium: the workbook then determines...

    Keywords: Lac OperonE. coli

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    Mark-Recapture
    A common method used to estimate the population size of a species is the Mark-Recapture method.

    Keywords: mark-recapture analysispopulation estimation

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    Linkage Analysis
    This Excel workbook simulates a linkage analysis problem with up to four alleles. Based on the offspring produced by a multihybrid testcross, the user builds a model of the gene order,...

    Keywords: recombinationlinkage analysis

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    Leslie/Lefkovitch Matrix Models for Age or Stage-structured Populations
    This Excel workbook uses the Leslie matrix model for population projection of age-class structured populations, and also allows Lefkovitch matrix models for stage-class structured populations.

    Keywords: survivalpopulation ecologyfecundityLeslie matrixeigenvalueseigenvectorsLefkovitch matrixage-class structured populationsstage-class structured populationsreproductive value

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    javaFOODWEB
    More than 100 food web matrices (multiple predators/prey Excel worksheets) are included with the javaFOODWEB tool.

    Keywords: niche spacesCommunity Ecologyfood webspredator-prey interactionsMatricestrophic chain

    129

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    Island Biogeography
    This Excel workbook demonstrates the principles of the MacArthur-Wilson theory of Island Biogeography. It allows the user to define the mainland species pool, area of the island, and distance of...

    Keywords: Logarithmsspecies richnessIsland biogeographyExponential FunctionsMacArthur-Wilson Theorypower functions

    109

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    Hidden Markov Model
    Hidden Markov models are a set of mathematical tools that can be used to draw inferences about genomic and evolutionary processes.

    Keywords: hidden markov models

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    GeoPhyl
    This Excel workbook allows students to explore evolution over space and time using published data on the invasive plant Tamarix (salt cedar).

    Keywords: Invasive SpeciesTamarixsalt cedarpermutation testrandom geographic distribution

    112

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    Genetic Code
    This Excel workbook allows the user to recreate the steps in breaking the genetic code. The user enters the sequence of repetitive synthetic mRNA strands, which are translated in vitro to produce...

    Keywords: mRNAgenetic code

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    Evolution Through Natural Selection
    This Excel workbook simulates the population genetics of a single gene with two alleles, allowing the user to set the initial allele frequencies and enter parameters for a variety of different...

    Keywords: population geneticsNatural Selection

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    ESS: Evolutionary Stable Strategies Game Theory Module
    This Excel workbook illustrates a number of ESS examples. Each example allows the user to manipulate the initial population for each strategy and the fitness payoffs and costs for each strategy.

    Keywords: population geneticsfitnessgame theorySequence alignmentevolutionary stable strategies

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    Dynamic Programming
    In bioinformatics, dynamic programming is mainly used to align nucleotide and amino acid sequences, and to predict RNA and protein folding from primary sequence data.

    Keywords: RNAamino acid sequenceSequence alignmentdynamic programmingprotein folding

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    Developmental Allometry: Scaling in Growth
    This Excel workbook illustrates a number of allometric equations in animal growth. The workbook also calculates an allometric equation with graphical output for data entered by the user.

    Keywords: allometrybrain developmentSkeletal Systemmetabolic rate

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