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Deme 2.0

Author(s): Anton E Weisstein

Truman State University

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Summary:
This workbook simulates the population genetics of a single gene with two alleles. It can simultaneously model up to three local populations, which may differ in their selection coefficients.

Licensed under CC Attribution-NonCommercial-ShareAlike 4.0 International according to these terms

Version 1.0 - published on 16 Aug 2024 doi:10.25334/QRCF-8649 - cite this

Keywords

  1. population genetics
  2. Genetic Drift
  3. Natural Selection

Alignments

  1. Resource Type
  2. Subdiscipline
  3. Audience Level
  4. Software Used
Contents:
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Overview

This workbook simulates the population genetics of a single gene with two alleles. It can simultaneously model up to three local populations, which may differ in their selection coefficients.

Popular Text Citations

Snustad D P, Simmons M J (2003) Principles of Genetics. 3rd Edition. New York : John Wiley & Sons, Inc.

Crow J F (1986) Basic Concepts in Population, Quantitative, and Evolutionary Genetics. New York : W. H. Freeman and Company.

Li C C (1955) Population Genetics. Chicago : University of Chicago Press.

Freeman S. and Herron J. C. 2004. Evolutionary Analysis, 2nd edition. Pearson Prentice Hall: Upper Saddle River, New Jersey.

Research Articles

Marmor M., Sheppard H.W., Donnell D., et al. 2001. Homozygous and heterozygous CCR5-(delta)32 genotypes are associated with resistance to HIV infection. J. Acquir. Immune Defic. Syndr. 27: 472-481.

Kokkotou E., Philippon V., Gueye-Ndiaye A., et al. 1998. Role of the CCR5 delta 32 allele in resistance to infection in west Africa. J. Hum. Virol. 1: 469-474.

Wellek S, 2004 Tests for establishing compatibility of an observed genotype distribution with Hardy-Weinberg Equilibrium in the case of a biallelic locus. Biometrics 60: 694-703.

Wittke-Thompson JK, Pluzhnikov A, Cox NJ, 2005 Rational inferences about departures from Hardy-Weinberg equilibrium. American Journal of Genetics 76: 967-86.

Hosking L, Lumsden S, Lewis K, Yeo A, McCarthy L, Bansal A, Riley J, Purvis I, Xu CF, 2004 Detection of genotyping errors by Hardy-Weinberg equilibrium testing. European Journal of Human Genetics 12: 395-9.

Education Research & Pedagogical Materials

Kaplan R. 1997. PopBio.

Alstad D.N. 2024. Populus.

Genes, Environment, and Human Behavior. Biological Sciences Curriculum Study (BSCS), 152pp (Snapshot: 2005-04-25)

Louisiana State University. 2006. Software for Population Genetic Analyses. (Snapshot: 2006-04-26)

Price F. and Vaughan V. 1998. EVOLVE. In The BioQUEST Library, Vol. VI (Jungck J.R., Calley J.N., Donovan S., Everse S.J., Soderberg P., Stanley E., Stewart J., eds). Academic Press: San Diego, CA.

Soderberg P. and Price F. 2003. An examination of problem-based teaching and learning in population genetics and evolution using EVOLVE, a computer simulation. Int. J. Sci. Educ. 25: 35-55.

Tutorial & Background Materials

The Hardy-Weinberg Equilibrium by John W. Kimball (Snapshot: 2007-01-26)

Citation

Researchers should cite this work as follows:

Fundamental Mathematical Concepts

Fundamental Mathematical Concepts
Hardy and Weinberg Equilibrium

Developed By

Developed by
Godfrey Hardy, Wilhelm Weinberg

Primary Reference

Weinberg, W., 1908 Ãœber den Nachweis der Vererbung beim Menschen. Jahresh. Wuertt. Ver. vaterl. Natkd. 64:369-382.

Hardy, G. H., 1908 Mendelian proportions in a mixed population. Science 28:49-50.