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Linkage Analysis

Author(s): Anton E Weisstein

Truman State University

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Summary:
This Excel workbook simulates a linkage analysis problem with up to four alleles. Based on the offspring produced by a multihybrid testcross, the user builds a model of the gene order, recombination frequencies, and linkage phase in the hybrid…

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This Excel workbook simulates a linkage analysis problem with up to four alleles. Based on the offspring produced by a multihybrid testcross, the user builds a model of the gene order, recombination frequencies, and linkage phase in the hybrid parent.

Licensed under CC Attribution-NonCommercial-ShareAlike 4.0 International according to these terms

Version 1.0 - published on 18 Aug 2024 doi:10.25334/H2Y4-SB61 - cite this

Keywords

  1. recombination
  2. linkage analysis

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Contents:
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Overview

This Excel workbook simulates a linkage analysis problem with up to four alleles. Based on the offspring produced by a multihybrid testcross, the user builds a model of the gene order, recombination frequencies, and liankge phase in the hybrid parent. He or she then conducts a mating experiment based on this model and compares the results to those from the original experiment to see if the model reasonably fits the data. The instructor may set overall parameters such as the number of genes, character and state names, and interference coefficient. (Note that this is a 3 MB file.)

Citation

Researchers should cite this work as follows:

Fundamental Mathematical Concepts

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