Cancer Biology

Part of Medicine in the Genomic Era, these resources examine the cellular processes of cancer cells, the genetic basis of cancer, the genes that are mutated in different types of cancers, and the role of mutations that occur during stem cell division.

cancer cell activity

HHMI BioInteractive Cancer Biology Resources:

Medicine in the Genomic Era Collection

Cancer Discovery Activities

Cell Division and Cancer Risk Data Point

Educator Publications of Modified Resources:

Many instructors modify and expand HHMI BioInteractive resources based on their course context and students, and QUBES offers a space to share these materials and teaching approaches. Some of these modifications were produced by participants in the 2016 HHMI/QUBES Faculty Mentoring Network. 

Read how Holly Basta uses Cancer Biology resources in her course on the BioInteractive Blog!

Data Analysis and Cancer

Lynn Marie Diener

Version: 1.0 Adapted From: The p53 Gene and Cancer v1.0

This is a flipped classroom approach, students will learn the basic content about cell-signaling, p53, and transcription factors before class. During class students will focus on data analysis applying what they learned to their interpretation of the data
Resources @ HHMI - BioInteractive, Biochemistry, molecular biology, data interpretation, Biological Data Analysis, cell cycle, macromolecules, Genetic disease, Cell signaling, introductory, Online course, Teaching material, Lecture, Undergraduate, Homework, Majors, 1 Hour, Promoting Engagement and Self-Efficacy

Bioimage Informatics Activity

David Julian

Version: 1.0.0 Adapted From: Cancer Discovery Activities v1.0

Students use basic bioimage informatics techniques to acquire quantitative data from images of cultured cells and test a hypothesis about the effect of a genetic mutation on cellular phenotypes
genetics, Resources @ HHMI - BioInteractive, genomics, cancer, genetic basis of disease, biology of cells, Teaching material, Undergraduate
This activity explores a specific gene (egfr) and its role in cancer. EGFR was introduced with the Gene Card Activities, researched throughout the semester, and then authentic image data of EGFR-mutated cells were analyzed.
Resources @ HHMI - BioInteractive, genomics, cancer, genetic basis of disease, biology of cells, Teaching material, Undergraduate, Advanced

Calculating Lifetime Cancer Risk Resulting from DNA Replication

Rebecca Orr, Ruth Buskirk, Kristin Harvey

Version: 1.0.0 Adapted From: Cell Division and Cancer Risk Data Point v1.0

An expanded case study adapted from an HHMI Data Point on Cell Division and Cancer Risk using Figure 1 from Tomasetti, C. and Vogelstein, B. (2015).
cancer, Scientific Process, Statistics and Math, Scientific Methodology, biology of cells, cell growth and division, Teaching material, High School, Undergraduate