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    Potential Scenario
    160

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    48

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    1969-Carl_Metzler-A mathematical model for the pharmacokinetics of LSD effect
    Contains data on performance scores vs. plasma levels of LSD in human tissues.
    LSDtestingpharmacokineticsperformanceplasma level
    Modeling Scenario
    208

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    239

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    5-020-ParacetamolAbsorption-ModelingScenario
    We offer drug absorption data on paracetamol, an analgesic pain reliever, for two different sets of patients, vegetarian and non-vegetarian. Students build a two compartment model for plasma and non-plasma (tissue) compartments of human patients.
    paracetamolanalgesicvegetariannon-vegetarian
    Modeling Scenario
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    194

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    5-012-LipoproteinModeling-ModelingScenario
    Data from a study on the amounts of low-density-lipoprotein (LDL), form of cholesterol, in blood plasma is presented. Students build, validate, and use a compartment model of the kinetic exchange of the LDL between body tissue and blood plasma.
    wildlifelow-density-lipoproteintracercompartment modelcholesterolblood plasmabody tissue
    Potential Scenario
    182

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    50

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    2012-Jambhekar-Breen-Extravascular Routes Of Drug Administration in Basic Pharamacokinetics
    This provides an excellent step-by-step of the physiology, construction of model, and notions like peak concentration as well as issues like lag time.
    concentrationphysiologydrugslag timeExtravascularPharamacokineticspeak time
    Potential Scenario
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    70

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    1968-Wagner-Aghajanian-Bing-Correlation of performance test scores with tissue concentration of lysergic acid diethylamide
    This paper offers a two compartment model of lysergic acid diethylamide (LSD) in volunteer students and through parameter estimation models the amount of LSD in the tissue after its initial administration through the plasma.
    LSDcorrelation coefficientcompartment modellysergic acid diethylamideperformancetest scoretissue concentration
    Modeling Scenario
    298

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    179

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    5-010-DNADegradation-ModelingScenario
    We ask students to use the system of first order linear differential equations given in a source paper and estimates of the data from laboratory procedures from a plot to estimate the parameters and complete the modeling process.
    DNA\kinetisplasmaratpharmacokinetis
    Potential Scenario
    165

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    45

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    1971-Boyes-Scott-Jebson-Godman-Julian-Lidocaine in Man
    Plasma levels of lidocaine were measured in 5 normal male volunteers following both intravenous and oral administration of the drug.
    pPharmacologypharmacokineticslidocaine
    Modeling Scenario
    310

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    228

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    1-085-DrugBolus-ModelingScenario
    Given data on the concentration of a drug in the plasma of a human in mg/L at certain time intervals in hours can we determine the rate at which the drug leaves the plasma as well as the initial amount administered in a intravenous bolus of the drug?
    concentrationsum of square errorsbolusdrugrate constantadminister
    Potential Scenario
    133

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    56

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    2017-ASHP-Intro to Pharmacokinetics and Pharmacodynamics
    This is the introductory Lesson 1 in an online set of materials to introduce Pharmacokinetics and Pharmacodynamics.
    absorptioncompartmentbloodstreamplasmapharmacokineticsdrugpharmacodynamics
    Potential Scenario
    140

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    80

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    2017-ASHP-Intro to Pharmacokinetics and Pharmacodynamics
    This is the introductory Lesson 1 in an online set of materials to introduce Pharmacokinetics and Pharmacodynamics.
    absorptioncompartmentbloodstreamplasmapharmacokineticspharmacodynamicstherapeutic concentration rangedrug dispositiondrug response
    Potential Scenario
    143

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    46

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    2005-Minna_Wedenberg-Pharmacokinetic modeling of gastric emptying
    The development of new drug substances is a complex, time consuming and expensive process. Reducing the time for drug development and avoiding late termination of candidate drugs are important challenges for the pharmaceutical industry.
    paracetamolpharmacokineticsstomachsmall intestinesulfapyridine
    Potential Scenario
    129

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    48

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    2010-Shianga-EtAl-Computational model of the human glucose-insulin regulatory system
    A computational model of insulin secretion and glucose metabolism for assisting the diagnosis of diabetes mellitus in clinical research is introduced. The
    glucose tolerance testsum of squared residualsmultiple shooting methodcost function
    Free Online Textbook
    189

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    54

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    2012-Vivek_Patel-Chemical Kinetics
    The book is designed to help the reader, particularly students, researchers, research scholars, scientists, chemists and industry fraternity of chemistry and allied fields; understand the mechanics and reactions rates.
    kineticschemistryreaction
    Modeling Scenario
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    3-065-UpDown-ModelingScenario
    We model the height of a launched object which is subject to resistance proportional to velocity during its flight. We ask questions about the motion as well, e.g., highest point or apex and terminal velocity.
    terminal velocityNewton's Second Law of Motionvelocitymotionapex
    Modeling Scenario
    403

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    506

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    1-047a-CondensationOptimization-ModelingScenario
    We seek to optimize a condensation process which is modeled by a simulation using the random motion of 200 particles in a 50 by 50 square in which a particle bounces off the two vertical and top walls and condenses on the bottom wall.
    simulationdataoptimizationenergycondensationbest fitcostsum of scquare errors
    Modeling Scenario
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    202

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    6-021-AcornsRodentsSnakes-ModelingScenario
    Students are given the opportunity to build a three tropic level model in which snakes eat rodents, rodents eat acorns, and acorns grow and occasionally mast.
    predationforestsnakesrodentsacornstrophic levelmasting
    Potential Scenario
    172

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    51

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    2017-Sim-EtAl-Optimal control of a coupled tanks system with model-reality differences
    In this paper, an efficient computational approach is proposed to optimize and control a coupled tanks system.
    optimal controlflowtankscoupled tanks
    Potential Scenario
    133

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    51

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    2011-GA_Koch-Noble-Drugs in the Classroom Using Pharmacokinetics to Introduce Biomathematical Modeling
    By beginning with simple model involving the half-life of a drug, students take advantage of their mathematical abilities to explore the biology.
    Biomathematicspharmacokinetics
    Potential Scenario
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    2009-Noakes-Sleigh-Mathematical models for assessing the role of airflow on the risk of airborne infection in hospital wards
    Understanding the risk of airborne transmission can provide important information for designing safe healthcare environments with an appropriate level of environmental control for mitigating risks.
    infectioncompartmenthospitalventilationairbornesthochasticWells–Riley
    Potential Scenario
    174

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    75

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    2012-Murray_Bourne-Modeling fish stocks
    Discusses many models of harvesting and consequences.
    fishlogisticmanagementsusustainable developmentharvestfish stockoverpopulatedunsustainable