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    Potential Scenario
    173

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    69

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    2002-Nelson-Perelson-Mathematical analysis of delay differential equations models of HIV-1 infection
    We develop and analyze a set of models that include intracellular delays, combination antiretroviral therapy, and the dynamics of both infected and uninfected T cells.
    infectionHIVT cells
    Potential Scenario
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    2014-Wang-EtAl-Estimating Mixed-Effects Differential Equation Models
    When multiple replicates of measurements are available for the dynamic process, it is of great interest to estimate mixed-effects in the ODE model for the process. We propose a semiparametric method to estimate mixed-effects ODE models.
    pharmacokineticsdynamic modelssmoothingsplinemixed-effects modelsHiV combination therapy
    Potential Scenario
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    47

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    2008-Huangi-Lu-Modeling long-term longitudinal HIV dynamics with applications to an AIDS clinical study 
    To better understand the factors responsible for the virological failure, this paper develops the mechanism-based nonlinear differential equation models for characterizing long-term viral dynamics with ARV therapy.
    longitudinal dataAIDSantiretroviral drug therapyBayesian nonlinear mixed-effectstime-varying drug efficacyHIV dynamics
    Potential Scenario
    217

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    60

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    2014-Bozkurt-Peker-Mathematical modelling of HIV epidemic and stability analysis
    A nonlinear mathematical model of differential equations with piecewise constant arguments is proposed. This model is analyzed by using the theory of both differential and difference equations to show the spread of HIV in a homogeneous population.
    diseaselogisticHIVpiecewise constantIndia
    Potential Scenario
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    51

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    2007-Zenker-Rubin-Clermont-From inverse problems in mathematical physiology to quantitative differential diagnoses
    The improved capacity to acquire quantitative data in a clinical setting has generally failed to improve outcomes in acutely ill patients, suggesting a need for advances in computer-supported data interpretation and decision making.
    physiologyinverse problem
    Potential Scenario
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    103

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    2017-Fred_Adler-Mathematically Modeling Asthma
    Our Asthma models have examined how a viral infection can tip the immune system into a different state, with the potential to predispose an individual to future asthma
    infectionasthmaimmune responserhinovirus
    Potential Scenario
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    69

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    2015-Zhang-EtAl-On the Selection of ODE Models with Application to Predator-Prey Dynamical Models
    We propose a computationally inexpensive approach that employs statistical estimation of the full model, followed by a combination of a least squares approximation (LSA) and the adaptive Lasso.
    least-squares approximationSpline modelingMonte Carlo simulationsvariable selectionadaptive LASSO
    Potential Scenario
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    2009-Su-EtAl-Fitting Compartmental Models to Multiple Dose Pharmacokinetic Data using SAS
    In the case of a multiple dose study where subjects experience different dosing times, a superposition principle can be used to recursively account for each additional dose.
    SASsuperpositionpharmacokineticscompartmental modelsmultiple dose
    Potential Scenario
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    38

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    2012-Shargel-Yu-AccessPharmacy-Applied Biopharmaceutics and Pharmacokinetics
    Step by step formation of drug absorption models is shown with many good graphics of system and plots. Solutions are offered but no solution methods are shown.
    Michaelis-MentenEnzymesubstratecompartmentpharmacokineticsrate constanturinary dataabsorption rate
    Potential Scenario
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    70

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    2015-Valerie_Billard-Pharmacokinetic-pharmacodynamic relationship of anesthetic drugs - from modeling to clinical use
    The purpose of this short review is to describe the basis of pharmacokinetics and modeling, the concentration-effects relationship, and drug interactions modeling to offer to anesthesiologists and non-anesthesiologists an overview of the rules to...
    anesthesiapharmacokineticspharmacodynamicanesthetic
    Modeling Scenario
    218

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    221

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    5-080-SpaceFlightRecolonize-ModelingScenario
    This project is a combination of differential equations, multi-variable calculus, and vector calculus with use of technology to model colonization of a new planet. Students solve a system of second order differential equations to model a planet
    optimizationsum of square errorsvector calculusLagrange multipliersline integrals
    Modeling Scenario
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    119

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    6-067-LotkaVolterra-ModelingScenario
    This modeling scenario guides students through the process of fitting the Lotka-Volterra model of two differential equations to a real time series observational data. Students use the capabilities of R and R studio.
    time seriesdatacompetitionLotka-Volterramodel fittingpredictiongauseRexperimental
    Potential Scenario
    177

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    57

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    1972-Suresh_Sethi-Optimal Control of the Vidale-Wolfe Advertising Model
    This paper considers an optimal-control problem for the dynamics of the Vidale-Wolfe advertising model, the optimal control being the rate of advertising expenditure to achieve a terminal market share within specified limits.
    Optimal Control Theoryadvertisingsales