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    Potential Scenario
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    1999-Khorasheh-Ahmadi-Gerayeli-Application of Direct Search Optimization for Pharmacokinetic Parameter Estimation
    For simple pharmacokinetic compartmental models, analytical solution to the governing differential equations provide a mean to evaluate the associated rate constants. Such methods, however, can not be used used for more complex multi-compartment...
    sum of square errorsleast squarespharmacokineticslineteicscompartmental modelsdirect search
    Modeling Scenario
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    6-029-TumorGrowth-ModelingScenario
    This modeling scenario guides a student familiar with single ordinary differential equation (ODE) models towards the development of a more complex system of two ODEs for describing the evolution of tumor growth over time.
    Pop_Growth Pilotlogisticcomparmenttumorsynthetic datasum of squares error
    Potential Scenario
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    1984-W_Brunner-D__Focht-Deterministic Three-Half-Order Kinetic Model for Microbial Degradation
    The kinetics of mineralization of carbonaceous substrates has been explained by a deterministic model which is applicable to either growth or nongrowth conditions in soil.
    kineticsnonlinear regressionsum of square errorsMonodlinearizemineralizationsubstratescarbonaceous
    Modeling Scenario
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    5-080-SpaceFlightRecolonize-ModelingScenario
    This project is a combination of differential equations, multi-variable calculus, and vector calculus with use of technology to model colonization of a new planet. Students solve a system of second order differential equations to model a planet
    optimizationsum of square errorsvector calculusLagrange multipliersline integrals
    Modeling Scenario
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    3-090-OneSpringMass-ModelingScenario
    We lead students through building a mathematical model for a single mass (bob)-spring system that is hanging vertically. We also lead the students, using data that they collect together with their model to approximate the value of the spring...
    undampedsum of square errorsmass springHooke's Lawoscilationleast-squares approximation
    Potential Scenario
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    2015-Zhang-EtAl-On the Selection of ODE Models with Application to Predator-Prey Dynamical Models
    We propose a computationally inexpensive approach that employs statistical estimation of the full model, followed by a combination of a least squares approximation (LSA) and the adaptive Lasso.
    least-squares approximationSpline modelingMonte Carlo simulationsvariable selectionadaptive LASSO
    Potential Scenario
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    1991-JR_Lobry-P_Flandois-Comparison of Monod's Growth Model Parameters from the Same Data Set
    The paper obtains the parameters in Monod's Growth model using a minimization of the sum of square errors with a given data set and obtains confidence intervals
    Confidence intervalssum of square errorslinearizationgrowthModo Growth model
    Potential Scenario
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    1975-Rodda-Sampson-Smith-The One-Compartment Open Model Parameter Estimation
    A new estimation procedure is proposed for estimating the parameters of the simplest pharmacokinetic model, the one-compartment open model.
    compartment modelpharmacokineticsnonlinear estimationone compartment model
    Modeling Scenario
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    3-015-StyrofoamBallFall-ModelingScenario
    We are given data on a falling Styrofoam ball and we seek to model this motion.
    footballresistancegravityfalling bodysum of square errorsNewton's Second Law of Motionsum of forcesstyrofoam
    Potential Scenario
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    2010-Shianga-EtAl-Computational model of the human glucose-insulin regulatory system
    A computational model of insulin secretion and glucose metabolism for assisting the diagnosis of diabetes mellitus in clinical research is introduced. The
    glucose tolerance testsum of squared residualsmultiple shooting methodcost function
    Potential Scenario
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    2015-Carl_Lutzer-Using Expected Value to Introduce the Laplace Transform
    We propose an introduction to the Laplace transform in which Riemann sums are used to approximate the expected net change in a function, assuming that it quantifies a process that can terminate at random.
    Expected ValueRiemann sumnet change
    Potential Scenario
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    2008-Brewer-EtAl-Fitting ordinary differential equations to short time course data
    In this paper, we present a survey of existing algorithms and describe the main approaches. We also introduce and evaluate a new efficient technique for estimating ODEs linear in parameters particularly suited to situations where noise levels are...
    time seriesEvaluation SPLINEgeneleast squaresbifurcation
    Potential Scenario
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    2017-Justin_Krueger-Parameter Estimation Methods for Ordinary Differential Equation Models with Applications to Microbiology
    We demonstrate the feasibility of principal differential analysis using simulation studies and then apply the method to intestinal and vaginal microbiota data.
    microbiologyLotka Volterrramicrobiota
    Modeling Scenario
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    1-066-USCensusModeling-ModelingScenario
    The United States Census, conducted every 10 years, gives data on the United States population, that can be modeled with the exponential, logistic, or Gompertz functions.
    datalogisticpopulationGompertzcensusgoodness of fit
    Modeling Scenario
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    3-010-EnergyInSpringMassSystem-ModlingScenario
    As a way to synthesize the effects of damping and forcing terms, this activity is meant to encourage students to explore how different forcing terms will change the total energy in a mass-spring system.
    energymass-spring systemkinetic energypotential energytotal energy
    Modeling Scenario
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    3-030-SecondOrderIntro-ModelingScenario
    We outline the solution strategies involved in solving second-order, linear, constant coefficient ordinary differential equations, both homogeneous and nonhomogeneous and offer many application and modeling activities.
    parameter estimationnon-homogeneousSpanishfrequencybuoyancyinverse problemthrustunderdampedfirst passagespring mash dashpotrealcomplexhomogeneoussuperpositionparachuteoverdampedcritically dampedbuoyquadratic equationrootsrocket flight
    Potential Scenario
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    2016-Pennell-Avitabile-White-Engineering Applications Differential Equations
    General discussion of an engineering based differential equations course with examples from RC Circuit, mass spring dashpot.
    circuitvoltagecapacitornondimensionalization
    Potential Scenario
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    2019-Hu-Treinen-One-step_method_for_modelling_longitudinal_data_with_differential_equations
    This study proposes a new approach to estimate the parameters in differential equation models used to describe non-linear trajectories of longitudinal data.
    simulationparameter estimationshoppingfittingbehaviour
    Modeling Scenario
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    1-061-PotatoCooling-ModelingScenario
    We model the cooling of a baked potato and compare it to student-collected data.
    least sum of square errorsNewton's Law of Coolingcoolingpotato
    Potential Scenario
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    2012-Jambhekar-Breen-Extravascular Routes Of Drug Administration in Basic Pharamacokinetics
    This provides an excellent step-by-step of the physiology, construction of model, and notions like peak concentration as well as issues like lag time.
    concentrationphysiologydrugslag timeExtravascularPharamacokineticspeak time