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    Modeling Scenario
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    6-017-OncolyticViruses-ModelingScenario
    Students explore oncolytic virotherapy using systems of differential equations and numerical simulations.
    cancercancer-immune dynamicsimmune suppressor drugoncolytic virusvirotherapy
    Modeling Scenario
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    337

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    1-062-BacteriaGrowth-ModelingScenario
    We offer students a simulation experience or data from a simulation and ask them to model the simulation using several approaches: exponential growth fit, difference equation, differential equation, and parameter estimation using EXCEL spreadsheet.
    bacteriaexponentialgrowth
    Modeling Scenario
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    115

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    6-045-CholeraTranmission-ModelingScenario
    During the project described here, the students will learn how to solve and address a practical problem such as cholera transmission using various mathematical tools.
    infectious diseasecholeraendemicdisease-freetransmission ratewaterborne pathogen
    Potential Scenario
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    97

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    2018-Joseph-EtAl-A Nonlinear differential equation model of Asthma effect of environmental pollution using LHAM
    In this paper, we investigated a nonlinear differential equation mathematical model to study the spread of asthma in the environmental pollutants from industry and mainly from tobacco smoke from smokers in different type of population.
    asthmatobacco smokeLiao’s Homotopy analysis Method (environmental pollutants
    Potential Scenario
    134

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    60

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    2016-Barbarossa-Kuttler-Mathematical Modeling of Bacteria Communication in Continuous Cultures
    This paper presents a simple system of delay differential equations (DDEs) for quorum sensing of Pseudomonas putida with one positive feedback plus one (delayed) negative feedback mechanism.
    gene regulatory networkschemostatbifurcationNumerical Simulationquorum sensing
    Potential Scenario
    200

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    73

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    2017-D_Goulet-Modeling, Simulating, and Parameter Fitting of Biochemical Kinetic Experiments
    In many chemical and biological applications, systems of differential equations containing unknown parameters are used to explain empirical observations and experimental data. The differential equations are typically nonlinear.
    optimizationBiochemistrysensitivity analysischromatographymass actioncluster analysisconservation lawsdimerizationestrogen receptor protein
    Potential Scenario
    306

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    54

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    1976-JG-Wagner-Computers in pharmacokinetics
    This is a seminal paper in pharmacokinetics in which the author introduces historic notions and approaches. As can be seen from the abstract there is a variety of material here.
    kineticscomputerparametersPharmacologydrugspharmacokinetics
    Potential Scenario
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    85

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    2017-Justin_Krueger-Parameter Estimation Methods for Ordinary Differential Equation Models with Applications to Microbiology
    We demonstrate the feasibility of principal differential analysis using simulation studies and then apply the method to intestinal and vaginal microbiota data.
    microbiologyLotka Volterrramicrobiota
    Potential Scenario
    220

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    65

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    2011-Lucas_Pulley-Analyzing Predator-Prey Models Using Systems of Ordinary Linear Differential Equations
    This research focused on applying biological mathematics to analyzing predation relationships, especially the relationship between the Canadian Lynx and the Snowshoe Hare.
    simulationpredator-preyLotka-VolterrapopulationCanadian LynxSnowshoe Harecritical values
    Modeling Scenario
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    1176

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    6-025-WhalesAndKrill-ModelingScenario
    Students will use Excel to observe qualitative behavior in a simulation of a predator-prey model, with blue whales and krill as the predator and prey populations, respectively.
    krillwhalepredatpr-prey
    Potential Scenario
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    89

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    2015-Boggess-EtAl-Mathematical Modeling in Ecology - Simulating the Reintroduction of the Extinct Passenger Pigeon
    To determine under which conditions a Passenger Pigeon could survive a reintroduction into a natural habitat, we used two types of models.
    simulationagent-based modelingallee_effectPassenger Pigeonsforest envirnomentHolling Type III functional responseBio-energeticstree distributions
    Potential Scenario
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    80

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    2014-Wang-EtAl-Estimating Mixed-Effects Differential Equation Models
    When multiple replicates of measurements are available for the dynamic process, it is of great interest to estimate mixed-effects in the ODE model for the process. We propose a semiparametric method to estimate mixed-effects ODE models.
    pharmacokineticsdynamic modelssmoothingsplinemixed-effects modelsHiV combination therapy
    Potential Scenario
    141

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    48

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    2012-Nokkaew-EtAl-Estimation of Algae Growth Model Parameters by a Double Layer Genetic Algorithm
    This paper presents a double layer genetic algorithm (DLGA) to improve performance of the information-constrained parameter estimations.
    optimizationalgae growthgenetic algorithmssimulated dataconvergence of parameters
    Potential Scenario
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    50

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    2011-Nguyen-Shi-Modeling the absorption circulation and metabolism of tirapazamine
    This apparently is a student project and it develops the kinetic model, uses Matlab for numerical solution, analytic solution and numerical solution.
    absorptionMichaelis-MentenMetabolismdrug metabolismcirculation
    Potential Scenario
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    62

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    2007-Mogen_Steffensen-Differential Equations in Finance and Life Insurance
    The mathematics of finance and the mathematics of life insurance were always intersecting. Life insurance contracts specify an exchange of streams of payments between the insurance company and the contract holder.
    financedisabilitylife insurancemortalityinsuraneThiele’s equationBlack-Scholes equation
    Potential Scenario
    185

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    74

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    1996-D_Erdman-MM_Morelock-A Study of Kinetics
    This paper introduces new and old features of the SAS System for the estimation and simulation of systems of first-order differential equations with emphasis on examples in kinetics.
    simulationkineticsparameter estimationEnzymesubstratesavingscompartmentstomachbloodginseng
    Technique Narrative
    397

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    204

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    9-001-SkinBurnModelNumericalMethods-TechniqueNarrative
    The heat equation is an important partial differential equation (PDE) which describes the distribution of heat in a given region over time. Numerical methods play an important role in solving these.
    Maternal-Fetal interfaceheat equationConservation of Energytheat fluxEuler's forward methodcentral differenceskin burnhyperthermiathermal conductivitylayers
    Article or Presentation
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    933

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    2020-TeachingModule-SpreadOfCommonColdSimulation
    This simulation is meant to introduce the idea of a differential equation model and investigate the impact of heightened hygiene and decreased interactions on the spread of an infectious disease. The focus of this simulation is on the common cold.
    simulationmoduleinfectious diseasediseasespreadTeaching Modulespread of disease
    Potential Scenario
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    2000-Erdman-Morelock-A Study of Kinetics The Estimation and Simulation of Systems of First-Order Differential Equations
    This paper introduces new and old features of the SAS System for the estimation and simulation of systems of first-order differential equations with emphasis on examples in kinetics.
    kineticsSAScompartmentpharmacokinetics
    Free Online Textbook
    464

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    95

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    2012-Brian_Ingalls-Mathematical Modelling in Systems Biology An Introduction
    This is a comprehensive text with much biology background to motivate the mathematical modeling, exercises and answers, and many rich examples.
    spatialsensitivity analysisgene regulatory networksstochasticbifurcationmetabolic networkselectrophysiologytransductionrate lawsbiochemical reactions