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1-016-DogDrugs-ModelingScenario

Author(s): Brian Winkel

SIMIODE - Systemic Initiative for Modeling Investigations and Opportunities with Differential Equations

Keywords: wild_dogs drug discovery half-life pentobarbital sodium anesthesia

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Abstract

Resource Image We offer a problem to determine the necessary drug administration in order to keep a dog sedated with specific information on half-life for an exponentially decaying presence of the drug in the body.

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Resource Type
Differential Equation Type
Technique
Qualitative Analysis
Application Area
Course
Course Level
Lesson Length
Technology
Approach
Skills
Key Scientific Process Skills
Assessment Type
Vision and Change Core Competencies - Ability
Principles of How People Learn
Bloom's Cognitive Level

Description

In the dog, an intravenous dose of 30 mg of pentobarbital sodium per kilogram of body weight will usually produce surgical anesthesia. Also in the dog, pentobarbital has a biological half-life of about 4.5 hours, due almost entirely to metabolism.

You anesthetize a 14-kg dog with the above dose of pentobarbital. Two hours later the anesthesia is obviously beginning to lighten and you want to restore the original depth of anesthesia. How many milligrams of pentobarbital sodium should you inject?

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Authors

Author(s): Brian Winkel

SIMIODE - Systemic Initiative for Modeling Investigations and Opportunities with Differential Equations

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