Abstract

Citation

Researchers should cite this work as follows:

• Winkel, B. (2022). 7-010-MultipleDoses-ModelingScenario. SIMIODE, QUBES Educational Resources. doi:10.25334/CCW1-E736

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Article Context

Description

You are to design an intravenous drug administration plan for a 24 hour span for a hospital patient. The patient has a port or shunt to their vein so medicine can be administered without further ``sticking.'' This medicine is to be administered in such a way that the amount of the drug in their blood stream must be between 2 and 4 mg throughout the 24 hour period. To go over 4 mg is to risk adverse effects and to go under 2 mg is to possibly not benefit from the drug. The drug is absorbed into the tissues where it does its work at the rate of 50% of the amount present in the bloodstream per hour.

Two possible multiple dose drug administration regimens are offered for modeling. A drug is to maintain a certain level (above a set minimum and below a set maximum) in the blood stream and one regimen involves bolus injections and the other involves steady drip flow over short periods of time. One of the regimens cannot meet the constraints and a modification is required of the students.