A Case of Severe Insulin Resistance (Student View)

Submitted by molecadmin on Mon, 01/20/2020 - 11:02

Authors: Melanie Lenahan (Raritan Valley Community College, NJ), and Shuchismita Dutta* (Rutgers University, NJ); *contact: sdutta@rcsb.rutgers.edu

Citation and Adaptations: doi:10.25334/DTTA-WW18 || Adaptations: Available from the table below. || Instructors: Login for Teacher View.

Work funded by NSF grant # DBI 1827011; 2018884

Image source: This image was created for this case in Molecular CaseNet. Please cite the case if you copy, post, or share it.

Molecules explored: The key molecules explored here include inactive Akt-2 kinase protein and its activated complexes with substrates bound to the protein.

Abstract
Keywords: hemoglobin, Fetal, Adult, Mutation, Oxygen binding
Why use this case
Discipline(s): Biology, Cell Biology
Resources to learn more, and the scientific article describing the case

Complete Case Study - Student Version
- Q: What caused the insulin resistance? Can it be treated?
Assessment - Student Version
- Q: The case of a constitutively active enzyme

Adaptation(s):

Authors+Date; DOI

Title

Adaptation

Notes

Johnson, K. A., July 2021; doi:10.25334/FW9S-2G51

Mol* Adaptation: Case of Severe Insulin Resistance

Adaptation - student view

Note: All parts of the case study have been included in a single document for easy downloading.

This is an adaptation using Mol* on the original case written. This case focuses on understanding how a mutation in a cell signalling protein (a kinase) can prevent insulin function and lead to diabetes.