Module 3: Transcription, Part II: What Happens to the Initial Transcript Made by RNA pol II?

Name: Module 3: Transcription, Part II: What Happens to the Initial Transcript Made by RNA pol II?
Published: 2020-07-25
License: CC Attribution-ShareAlike 4.0 International

Cathy Silver Key; Chiyedza Small; Laura Reed

doi:10.25334/PYZN-JQ45

Module 3: Transcription, Part II: What Happens to the Initial Transcript Made by RNA pol II?

By Cathy Silver Key¹, Chiyedza Small², Laura Reed³

1. North Carolina Central University 2. Medgar Evers College CUNY 3. The University of Alabama

This module teaches about the three key steps that are involved in converting the pre-mRNA into a mature mRNA: 1) The addition of a 5’ cap, 2) The addition of a 3’ poly(A) tail, 3) The removal of introns through splicing.

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Description

This module demonstrates how the transcript generated by RNA polymerase II (the pre-mRNA) is processed to become mature mRNA using the sequence signals identified in Module 2. After completing this module, students will be able to use the genome browser to explain the relationships among pre-mRNA, 5' capping, 3' polyadenylation, splicing, and mRNA. The specific nucleotide sequences that guide the maturation process are highlighted. Students will observe that introns are removed during this process and adjacent exons are brought together in the mRNA message.