This classroom activity uses the information presented in the short film The Making of the Fittest: Natural Selection in Humans to take students through a series of questions pertaining to the genetics of sickle cell disease and its relationship to malaria resistance. The questions are divided into sections: Mendelian Genetics and Probability, Pedigrees, and Chi-Square Statistics. Within each section, the questions sequentially move from a basic level to a more advanced level in order to develop the skills of the students.
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