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1957-Axelrod_ Brady_Witkop_Evarts-The Distribution and Metabolism of Lysergic Acid Diethylamide

Author(s): Julius Axelrod

N/A

Keywords: mathematical model data LSD Metabolism bloodstream lysergic acid diethylamide distribution

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Abstract

Resource Image The development of a specific and sensitive method for the estimation of LSD in biological materials has enabled us to study the tissue distribution, excretion, rate of biotransformation, and metabolism of the drug, as well as the subcellular processes in

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Late in the 1950s, Axelrod became interested in the distribution, excretion, metabolization and rate of "biotransformation" of lysergic acid diethylamide (LSD) by the body. In this first of several articles on the narcotic drug, he detailed the subcellular processes involved in the transformation of LSD, determined the order of concentrations of the drug in various tissues, determined that it was almost completely metabolized by the body, and found that their were considerable differences between various animal species in the rate of biotransformation of LSD.

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Author(s): Julius Axelrod

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