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Evolution Through Natural Selection

Author(s): Timothy Comar

Benedictine University

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Summary:
This Excel workbook simulates the population genetics of a single gene with two alleles, allowing the user to set the initial allele frequencies and enter parameters for a variety of different selection models.

Licensed under CC Attribution-NonCommercial-ShareAlike 4.0 International according to these terms

Version 1.0 - published on 17 Aug 2024 doi:10.25334/84JM-5G91 - cite this

Keywords

  1. population genetics
  2. Natural Selection

Alignments

  1. Resource Type
  2. Subdiscipline
  3. Audience Level
  4. Software Used
Contents:
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Overview

This Excel workbook simulates the population genetics of a single gene with two alleles, allowing the user to set the initial allele frequencies and enter parameters for a variety of different selection models; the program then tracks the population through up to 10,000 generations.

Popular Text Citations

Snustad D P, Simmons M J (2003) Principles of Genetics. 3rd Edition. New York : John Wiley & Sons, Inc.

Freeman S. and Herron J. C. 2004. Evolutionary Analysis, 2nd edition. Pearson Prentice Hall: Upper Saddle River, New Jersey.

Li C C (1955) Population Genetics. Chicago : University of Chicago Press.

Crow J F (1986) Basic Concepts in Population, Quantitative, and Evolutionary Genetics. New York : W. H. Freeman and Company.

Research Articles

Hosking L, Lumsden S, Lewis K, Yeo A, McCarthy L, Bansal A, Riley J, Purvis I, Xu CF, 2004 Detection of genotyping errors by Hardy-Weinberg equilibrium testing. European Journal of Human Genetics 12: 395-9.

Wittke-Thompson JK, Pluzhnikov A, Cox NJ, 2005 Rational inferences about departures from Hardy-Weinberg equilibrium. American Journal of Genetics 76: 967-86.

Wellek S, 2004 Tests for establishing compatibility of an observed genotype distribution with Hardy-Weinberg Equilibrium in the case of a biallelic locus. Biometrics 60: 694-703.

Kokkotou E., Philippon V., Gueye-Ndiaye A., et al. 1998. Role of the CCR5 delta 32 allele in resistance to infection in west Africa. J. Hum. Virol. 1: 469-474.

Marmor M., Sheppard H.W., Donnell D., et al. 2001. Homozygous and heterozygous CCR5-(delta)32 genotypes are associated with resistance to HIV infection. J. Acquir. Immune Defic. Syndr. 27: 472-481.

Education Research & Pedagogical Materials

Price F. and Vaughan V. 1998. EVOLVE. In The BioQUEST Library, Vol. VI (Jungck J.R., Calley J.N., Donovan S., Everse S.J., Soderberg P., Stanley E., Stewart J., eds). Academic Press: San Diego, CA.

Louisiana State University. 2000. Software for Population Genetic Analyses. (Snapshot: 2006-04-26)

Genes, Environment, and Human Behavior. Biological Sciences Curriculum Study (BSCS), 152pp

Alstad D.N. 2004. Populus.

Kaplan R. 1997. PopBio.

Tutorial & Background Materials

The Hardy-Weinberg Equilibrium by John W. Kimball (Snapshot: 2007-01-26)

Citation

Researchers should cite this work as follows:

Fundamental Mathematical Concepts

Fundamental Mathematical Concepts
Hardy and Weinberg Equilibrium

Developed By

Developed by
Godfrey Hardy, Wilhelm Weinberg

Primary Reference

Hardy, G. H., 1908 Mendelian proportions in a mixed population. Science 28:49-50.

Weinberg, W., 1908 Über den Nachweis der Vererbung beim Menschen. Jahresh. Wuertt. Ver. vaterl. Natkd. 64:369-382.