In this activity, students learned about the immune response to infection by exploring different types of tests—PCR, antigen, and antibody tests—to detect SARS-CoV-2 viral genetic material, antigens, or anti-SARS-CoV-2 antibodies. Students applied core concepts and competencies from Vision & Change (https://visionandchange.org/). The activity followed a jigsaw format, where students selected one of three specialties (epidemiologist, infectious disease doctor, or immunologist) and completed an assignment, either in-class or as homework, based on their chosen specialty. Preliminary data from a single-institution implementation showed a statistically significant increase in total scores and in 2 out of 5 test questions on a concept-based test after completing the activity. On a Likert scale, students reported that the background information provided was sufficient and engaging. These results will inform future iterations of this activity.