Support

Support Options

  • Knowledge Base

    Find information on common questions and issues.

  • Support Messages

    Check on the status of your correspondences with members of the QUBES team.

Contact Us

About you
About the problem
Resource Image

Bioinformatics - Investigating Sequence Similarity

Author(s): Adam Kleinschmit1, Benita Brink1, Steven Roof2, Komal Vig3

1. Adams State University 2. Hampshire College 3. Alabama State University

288 total view(s), 56 download(s)

Summary:

This laboratory module, leads introductory biology students in the exploration of a basic set of bioinformatics concepts and tools.

Contents:

Description

This laboratory module, leads introductory biology students in the exploration of a basic set of bioinformatics concepts and tools. The exercise utilizes simple paper models to help students understand matrices and algorithms prior to use of web-based computational tools. Students start the module by defining sequence similarity and then investigating how similarity can be quantitatively compared between two similar length proteins using a BLOSUM scoring matrix. Students then consider finding local regions of similarity between a sequence query and subjects within a large database using BLAST. Lastly, students practice accessing FASTA formatted sequence information via NCBI databases as they collect sequences for a multiple sequence alignment in order to generate a phylogenetic tree.