Resources
EvolSeq
Author(s): Tony Weisstein1, John R Jungck2
1. Truman State University 2. Interdisciplinary Science Learning Center at the University of Delaware
1383 total view(s), 313 download(s)
- EvolSeq_1.1.xls(XLS | 832 KB)
- EvolSeq_1.2.xls(XLS | 847 KB)
- License terms
Overview
This worksheet simulates the molecular evolution of DNA sequences. The program begins with a single (random) sequence, then follows that sequence through time as it reproduces and mutates. Eventually, up to 20 evolutionary related sequences are generated. EvolSeq then calculates the genetic distances between each pair of DNA sequences, and also between the associated amino acid sequences.
Popular Text Citations
Mount D.W. 2001. Bioinformatics: Sequence and Genome Analysis, pp. 237-280. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, New York.
Kimura, M. 1983. The Neutral Theory of Molecular Evolution. Cambridge University Press, Cambridge
Kimura, M. 1994. Population Genetics, Molecular Evolution, and the Neutral Theory: Selected Papers, University of Chicago Press.
Lewontin, R. 1974. The Genetic Basis of Evolutionary Change. Columbia University Press.
Research Articles
Ohta, T. 1992. "The nearly neutral theory of molecular evolution". Annual Review of Ecology and Systematics 23: 263-286.
Ohta, T. 1973. "Slightly deleterious mutant substitutions in evolution". Nature 246: 96-98.
Ohta, T. 2002. "Near-neutrality in evolution of genes and gene regulation". Proceedings of the National Academy of Sciences 99: 16134-16137
Sueoka, N. 1962. "On the genetic basis of variation and heterogeneity of DNA base composition". PNAS USA 48: 582–592
Ohta, T. and Gillespie, J.H. 1996. "Development of Neutral and Nearly Neutral Theories". Theoretical Population Biology 49: 128-142.
Kimura, M. 1991. The neutral theory of molecular evolution: a review of recent evidence. Jpn J Genet 66:367-86.
Data Sources
Smith, C.M. 2004. CMS Molecular Biology Resource
Tutorial & Background Materials
Holsinger, K. E. The Neutral Theory of Molecular Evolution (broken link - http://darwin.eeb.uconn.edu/eeb348/lecture-notes/molevol-neutral.pdf)
Golding B. and Morton D. 2003. Elementary Sequence Analysis, chapter 9.
Guttman D.S. 2004. Bio472H1S Computational Genomics and Bioinformatics Course Notes, Feb 4. (broken link - http://www.botany.utoronto.ca/courses/bio472/Bio472-Phylogenetics1-4spp.pdf)
Joyce D.E. 1996. Phylogeny and Reconstructing Phylogenetic Trees.
Weston P.H. and Crisp M.D. 1998. Introduction to Phylogenetic Systematics.
Citation
Researchers should cite this work as follows:
- Weisstein, T. E., Jungck, J. R. (2018). EvolSeq. ESTEEM, QUBES Educational Resources. doi:10.25334/Q44B01
Fundamental Mathematical Concepts
Developed By
Primary Reference
Kimura, M. 1968. "Evolutionary rate at the molecular level". Nature 217: 624-626