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    Splicing it Together: Using Primary Data to Explore RNA Splicing and Gene Expression in Large-Lecture Introductory Biology
    At the heart of scientific ways of knowing is the systematic collection and analysis of data, which is then used to propose an explanation of how the world works. In this two-day module, students...

    Keywords: gene regulationtranscriptiongene expressioncentral dogmarepressoralternative splicingmRNA processingActivatorTranscription factors

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    An undergraduate bioinformatics curriculum that teaches eukaryotic gene structure
    Gene structure, transcription, translation, and alternative splicing are challenging concepts for many undergraduates studying biology. These topics are typically covered in a traditional lecture...

    Keywords: bioinformaticsGenome BrowsergenomicsRNAseqsplicingComputer ModelGene Structure

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    A Multi-Institutional Alternative Assessment Faculty Learning Community: Supporting Teaching in Higher Education
    Faculty learning communities (FLCs) provide opportunities for professional development for faculty, teaching staff, and educational developers in a collaborative and open environment. In this...

    Keywords: professional developmentAlternative AssessmentFaculty Learning Community

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    A Fun Introductory Command Line Lesson: Next Generation Sequencing Quality Analysis with Emoji!
    Radical innovations in DNA sequencing technology over the past decade have created an increased need for computational bioinformatics analyses in the 21st century STEM workforce. Recent...

    Keywords: bioinformaticsgenomicscodingJupyter notebookcommand lineCyVersescriptingnext generation sequencing analysis

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    A Hands-on Introduction to Hidden Markov Models
    In this Lesson, we describe a classroom activity that demonstrates how a Hidden Markov Model (HMM) is applied to predict a eukaryotic gene, focusing on predicting one exon-intron boundary. This HMM...

    Keywords: transcriptionexonintronsplicing

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    Three Research-Based Quantitative Reasoning Modules for Introductory Organismal Biology Laboratories
    We have designed three laboratory modules for an introductory organismal biology course with an emphasis on quantitative reasoning and data analysis skills. Module 1 tests for dimorphism in...

    Keywords: allometryplantsAnatomytranspirationdimorphisminvertebrate biologyarthropodsplatyhelminths

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    Follow the Sulfur: Using Yeast Mutants to Study a Metabolic Pathway
    Students are frequently overwhelmed by the complexity of metabolic pathways and they think they have "learned" the pathway when they have memorized the individual reactions.  This...

    Keywords: SelectionyeastMetabolismcysteinemediamethioninemutantPathwaysulfur

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    The Flight Physics Concept Inventory: Reliably Evaluating Aerodynamic Lift, Drag and Associated (Naïve) Concepts of Flight in Class and In-Game
    Students often struggle to transfer conceptual understanding from isolated instruction to a coherent mental model. This is especially true for the context of flight physics, fluid dynamics, or the...

    Keywords: active learninggamificationmisconceptionsaerodynamicsfluid dynamicsResearch-based assessment instrumentConceptual SurveyPRE-/POST-test

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    Glycolysis Can Be Fun: Rediscovering Glycolysis as a Problem-Solving Introduction to Metabolism
    A thorough understanding of glycolysis forms a foundation for students to analyze subsequent topics in metabolism, a core competency recognized by multiple national societies for biology and...

    Keywords: Problem based learningPOGILenzymesGlycolysisMetabolismFermentationchemical reactionsCard sorting activityCofactors

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    Predicting and classifying effects of insertion and deletion mutations on protein coding regions
    Mutations in genes can affect the encoded proteins in multiple ways, and some of these effects are counterintuitive. As for any other knowledge, students must create their own deep understanding of...

    Keywords: mutationcentral dogmatranslationframeshift

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    Linking Genotype to Phenotype: The Effect of a Mutation in Gibberellic Acid Production on Plant Germination
    Basic concepts in genetics and plant development are often taught in lecture courses without a lab component. This approach provides students with the content knowledge, but fails to make...

    Keywords: geneticsdevelopmentmutationgerminationplantmodel organismGenotype/PhenotypeHormoneSeed

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    An Original-Design Board Game to Increase Student Comprehension of Cellular Respiration Pathways
    Cellular respiration is a daunting topic for many students in introductory biology courses. Students are challenged at conceptual and factual levels, since instruction covers multiple metabolic...

    Keywords: GlycolysisCellular RespirationFermentationKrebs CycleOxidative phosphorylationpyruvate oxidation

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    Does Organelle Shape Matter?: Exploring Patterns in Cell Shape and Structure with High-Throughput (HT) Imaging
    Organelle structure has been studied and visualized for decades; however, publicly available databases that use improved high-throughput microscopy of gene-edited cell lines have recently...

    Keywords: modelingcase studymicroscopystructureOrganellesHigh-throughput (HT)Endoplasmic Reticulum (ER)Fluorescent microscopyHuman Cell Biology

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    Discovering Cellular Respiration with Computational Modeling and Simulations
    Cellular respiration, a common topic among introductory and cellular biology curricula, is a complex biological process that exemplifies core biological concepts, including systems, pathways and...

    Keywords: Cellular MechanismsCellular RespirationFermentation

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    Sex-specific differences in Meiosis: Real-world applications
    In traditional classrooms, students are typically presented with facts that they are asked to memorize and recall during an exam.  The rapid explosion of available scientific facts in recent...

    Keywords: meiosisReproductionAneuploidyGameteNon-disjunctionOocyteSpermTrisomy

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    Manuscript 101: A Data-Driven Writing Exercise for Beginning Scientists
    Learning to write a scientific manuscript is one of the most important and rewarding scientific training experiences, yet most young scientists only embark on this experience relatively late in...

    Keywords: geneticsanimaldevelopmentcompetitionbacterial

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    Data, Distributions, and Hypotheses: Exploring Diversity and Disturbance in the Tallgrass Prairie
    Proper hypothesis generation, data handling, graphing, and communication are essential skills that undergraduate majors in biology are expected to master. However, students rarely get hands-on...

    Keywords: Quantitative reasoningRestoration EcologyScience process skillstall grass prairie ecosystem

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    Gender and Classroom Participation: A Case for Quantitative Analysis
    Teaching statistics to students using authentic research is one way to highlight the transferability and value of the material taught in the class. Below we describe an activity in Statistics for...

    Keywords: statisticsgenderpopulationProportionSampleEquality

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    Central Dogma, Dictionaries, and Functions: Using Programming Concepts to Simulate Biological Processes
    Technologies like next-generation sequencing, proteomics, and high-throughput phenotyping have transformed the way we do biology. There is a continued need for scientists with computational skills...

    Keywords: computationpythonJupyter notebookFunctionscentral dogmaDictionaries

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    Fatty Acid Induction of Lipid Droplets in Cancer Cells
    There is a growing need for the development and communication of cell culture-based laboratory activities specifically designed for undergraduate students. This multi-week laboratory activity...

    Keywords: Course based undergraduate researchCell ImagingLive Cell Staining

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