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    Regulation of Gene Expression and Adipogenesis by PPAR-γ
    Students learn about transcriptional regulation of PPAR-γ, an important controller of adipose tissue stores and energy metabolism through a drawing/coloring activity of the different components...

    Keywords: gene expressionsmall group worktranscriptional regulationadipose tissuefat metabolismrepressor

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    Instructor Guide: Integrating Project Leadership, Artificial Intelligence, Simulation and Google Tools to Understand Regulation of Gene Expression with the Lac Operon and Lactase Gene
    Scientific leadership and current artificial intelligence (AI) skills are important skills to be included in the course curriculum. Together or individually, these skills can enhance knowledge,...

    Keywords: Resources @ HHMI - BioInteractivebiologymolecular biologygenomicsArtificial Intelligencegene expressionleadershipgroup worklactosegoogle toolsSeniorPhET SimulationLactase

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    Introduction to Genome Browser: What is a Gene?
    In this module, we will use a web-based visualization tool called a Genome Browser to explore the structure of a eukaryotic gene, and obtain a basic understanding of how this information is...
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    "Got Algae?" A Sorting Game for Introducing the Weird and Wonderful Diversity of Algae
    Algae are a fascinating and diverse organismal group, with global ecological importance, a storied evolutionary history and deep connections to both contemporary and historical human societies. Yet...

    Keywords: phylogenyBiodiversityphotosynthesisalgaeseaweedmonophyly

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    An Interactive Protocol for In-Classroom DNA Extraction
    Using commonly available materials, this tool allows students to extract DNA, exploring DNA chemistry and the principles of experimental design and execution. We take a “Choose Your Own...

    Keywords: geneticsDNAbiochemical structure and function

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    Exploring Microbial Diversity: An Interactive In-Class Assignment for Biology and Microbiology Courses
    This interactive assignment engages students in a hands-on exploration of microbial diversity and the importance of microbes in ecosystems. Designed for General Biology II and Introduction to...

    Keywords: Microbiology EducationMicrobial DiversitymicrobiologyEcological Society of Americaecology educationresearch-based classroom instruction4DEE Framework

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    Helping Students to Overcome STUMPS: Scientific terms undermined by meanings peripheral to science
    Many terms and phrases that are ubiquitous in everyday use have very different meanings in science. As a result, biology students often hold prior conceptions that are difficult to change. In this...

    Keywords: Evolutionfitnessprocess of sciencetree of lifemetacognitionlanguagemisconceptionsTerminologyTheory

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    Bacteria to Brains in Backyard Coyotes: An Interdisciplinary Pedagogical Case Study
    Our interdisciplinary pedagogical case study explores the differences between rural and urban coyotes at the levels of organismal and community ecology. The focus is on how coyotes’ gut...

    Keywords: dietanimal behaviorimmune systemmicrobiomeNervous systemgut-brain axisImmunoReachdysbiosisCoyoteCytokines

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    Necessary and Sufficient? Solving the Mystery of the Mitochondrial Pyruvate Transporter
    While there are several available lessons for teaching introductory biology students about diffusion, facilitated diffusion, and active transport, fewer materials exist to support upper-division...

    Keywords: DiffusionActive transportfacilitated diffusionNecessary and sufficientTransport proteins

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    Linking Genotype to Phenotype: The Effect of a Mutation in Gibberellic Acid Production on Plant Germination
    Basic concepts in genetics and plant development are often taught in lecture courses without a lab component. This approach provides students with the content knowledge, but fails to make...

    Keywords: geneticsdevelopmentmutationgerminationplantmodel organismGenotype/PhenotypeHormoneSeed

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    Graphical Organizers as Course Road Maps: Using a geologic timescale in a history of life course
    Both major and non-major biology students lack understanding of important evolutionary events, how they are spaced in time, and how they relate back to the earth system. Graphical organizers like...

    Keywords: Evolutionecologyextinctionadaptive radiationdiversification

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    Understanding the Importance of Microtubules in Normal Cell Division: Chemotherapy Connection
    In introductory courses, students learn about microtubules as important structures but may not engage in a hands-on experience to localize microtubules themselves or to learn about their connection...

    Keywords: cancerCell DivisionimmunofluorescenceMicrotubulesAntibodies

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    Good Drug, Bad Practice: Tackling the Ivermectin Fiasco
    Throughout history, biomedical advancements have alleviated suffering worldwide and significantly advanced human well-being. As researchers and educators, we are well-familiar with the...

    Keywords: Peer reviewCOVID19fraudtherapeutic drugIvermectin

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    Small Organisms with Big Consequences: Understanding the Microbial World Around Us
    Creating a hands-on lab that conveys important information while simultaneously allowing for student autonomy can be difficult. This is particularly true for the field of microbiology, in which...

    Keywords: disease transmissionmicrobiologymicrobiomeliterature reviewPeer reviewPathogensHealth and WellnessThe Scientific Method

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    Assessing in vivo Antimicrobial Activity Through the Analysis of Galleria mellonella Kaplan-Meier Plots
    Antimicrobials and their use in the treatment of bacterial infections are a fundamental lesson in all microbiology courses. Typically, cultivation-based methods are used to teach students about...

    Keywords: Antimicrobial TestingAntimicrobialsInvertebrate animal models

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    Discovering Prokaryotic Gene Regulation by Building and Investigating a Computational Model of the lac Operon
    The ability to construct and reason through a biological system is an important skill to develop in science education. This level of understanding forces students to recognize the interrelatedness...

    Keywords: prokaryotesgene regulationLac Operoninducible operon

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    CRISPR/Cas9 in yeast: a multi-week laboratory exercise for undergraduate students
    Providing undergraduate life-science students with a course-based research experience that utilizes cutting-edge technology, is tractable for students, and is manageable as an instructor is a...

    Keywords: bioinformaticsPCRphenotypingCRISPR/Cas9gene editingcloningGenotypingRestriction enzyme

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    Investigating Cell Signaling with Gene Expression Datasets
    Modern molecular biology is a data- and computationally-intensive field with few instructional resources for introducing undergraduate students to the requisite skills and techniques for analyzing...

    Keywords: genomicstranscriptionsignaling

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    Discovering Prokaryotic Gene Regulation with Simulations of the trp Operon
    The trp operon exemplifies important biological concepts, including the central dogma of molecular biology, feedback inhibition, and gene regulation. For this reason, regulation of the trp operon...

    Keywords: prokaryotesgene regulationattenuationfeedback inhibitionrepressible operontrp operon

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    Antibiotic Resistance Genes Detection in Environmental Samples
    Our aim is to provide an authentic research experience for undergraduate students in a variety of biology courses through collaboration between a four-year university and a community college. This...

    Keywords: geneticsenvironmentmicrobiologyUndergraduateantibiotic-resistancePCRgel electrophoresisauthentic inquiry

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