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    Split Decomp
    This Excel worksheet performs split decomposition on a set of four DNA sequences and their associated amino acid sequences. The user can type in the sequences or paste them in from a text file.
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    Creating Phylogenetic Trees from DNA Sequences
    This interactive module shows how DNA sequences can be used to infer evolutionary relationships among organisms and represent them as phylogenetic trees.
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    EvolSeq
    An Excel worksheet that simulates the molecular evolution of DNA sequences.
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    Dynamic Programming
    In bioinformatics, dynamic programming is mainly used to align nucleotide and amino acid sequences, and to predict RNA and protein folding from primary sequence data.
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    Protein Analysis
    This Excel workbook allows the analysis of sample or imported protein sequences. The model can analyze protein sequences up to 500 amino acids long.
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    Functional and structural analysis of Amylase activity
    This exercise was developed to allow students to apply the scientific method and use their knowledge of enzymes to investigate the relationship between enzyme activity and structure. Students...
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    Bioinformatics: CpG Islands
    This is an introductory bioinformatics exercise intended for use in a genetics course.
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    NCBI Overview
    An overview of some of the databases within NCBI and how to get FASTA sequences.
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    GEA Introductory lesson on BLAST
    The "Introduction to BLAST using Human Leptin" exercise aims to introduce students to the use of the Basic Local Alignment Search Tool (BLAST) to identify related sequences and compare similarity...
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    DNA Barcoding & Biodiversity databases
    This resource pairs DNA barcoding databases with Biodiversity databases. Students collect their insect specimens in the field and use BLAST and BOLD to identify their species. They then use...
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    Trout modeling example
    This is an open-ended modeling example using difference equations and Algebra II skills.

    Keywords: population biology

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    In silico chromosome mapping: Idiograms
    This workbook allows the user to construct idiograms (haploid or diploid), map sequences onto them, depict chromosome structural mutations, and perform side-by-side comparative analyses of...
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    Murder by HIV? Undergraduate edition
    Bioinformatics case study focusing on phylogenetic tree interpretation, published in the National Center for Case Study Teaching in Science
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    Bioinformatics: Food Detective – a Practical Guide
    This Practical Guide in the Bringing Bioinformatics into the Classroom series introduces the idea of computers as tools to help understand aspects of biology.
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    Module 4: Removal of Introns from pre-mRNA by Splicing
    In this module, students will learn to identify splice donor and acceptor sites that are best supported by RNA-Seq data, and use the canonical splice donor and splice acceptor sequences to identify...
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    Neochromosomes: Creating transcriptional units with yeast Golden Gate assembly
    This resource is a series of protocols using the yeast Golden Gate (yGG) method as developed by Neta Agmon and Leslie Mitchell in Jef Boeke’s lab to assemble a functional yeast gene with...
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    Using DNA Subway to Analyze Sequence Relationships
    This is a bioinformatics exercise using the DNA Subway Blue Line, a user-friendly pipeline of bioinformatics tools, to analyze a collection of mosquito DNA bar-code sequences.
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    COVID-19: Molecular Basis of Infection-ADAPTATION
    This case was written in Spring 2020 during the COVID-19 pandemic. It focuses on understanding the structure and interaction of the SARS-Cov-2 viral spike protein that facilitates infection in...
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    Databases: A Study of Influenza
    This lesson introduces the student to the Influenza Research Database. Students will select Influenza genome sequences to see how they are related. Students tests hypotheses about evolutionary...
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    Lesson IV - Comparative Genomics
    Genome Solver began as a way to teach undergraduate faculty some basic skills in bioinformatics; no coding or scripting is required. Lesson IV, Comparative Genomics, discusses some of the tools...
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