| 1 | <p>In order to prevent a virus from spreading, cytotoxic T cells (also known as CTLs) identify and eliminate cells that have already been infected. The animation illustrates how infected cells cut up viral proteins and present the fragments, called antigens, on their surfaces using MHC class I molecules. When a cytotoxic T cell recognizes that the protein fragment is foreign in origin, it triggers the release of proteins that destroy the infected cell, preventing it from producing more viruses.</p>
| 1 | <p>Anatomy and physiology students historically have a difficult time learning the complicated inter-workings of the immune system. The following is an in-class learning activity designed to utilize 50 minutes of face-to-face (or synchronous online) lecture for pre-Nursing students at a 2- or 4-year university. The activity is targeted to one aspect of the adaptive immune system, CTL antigen presentation. The goal is to organize the material into smaller, more manageable sections using 3 short clips from a pre-existing HHMI Biointeractive animation (adapted specifically for this activity), followed by targeted student discussion (think/pair/share). A student response system (such as clickers) is also a feature of this activity that incorporates questions designed to gauge understanding in real-time. Applications to the real-world using a simple case study and medical research offer the students a chance to think critically and an engaging connection to personal interests. After this activity students will:</p>
|
|---|