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#1010, v1.0 Published:
#1343, v1.0 Published:

Title

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1Regulation of Gene Expression and Adipogenesis by PPAR-γ 1Regulación de expresión génica y adipogénesis por PPAR-γ

Authors

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1Gary Laverty ()   
2Thomas John Peters ()   
3Juan Sebastián Ramírez-Lugo () 1Juan Sebastián Ramírez-Lugo () 
4Denise Levin Signorelli () 4Juan Sebastián Ramírez-Lugo ()
5Saumya Ramanathan ()   
6Gary Laverty ()   

Description

Old VersionNew Version
1<p>This resource is meant to complement the short video &quot;PPAR-gamma Activation in the Fat Cell,&quot; an HHMI BioInteractive Video Resource. The activity uses PPAR-&gamma; as an example of transcriptional regulation by negative control, and can also be used to lead into discussions of cell signaling, insulin and diabetes. In the activity students will complete a coloring and analysis activity and arrange the elements of a gene and its regulatory elements, as well as&nbsp; analyze how a manufactured drug can function as an activator of this process. Students will also compare and contrast the effect of gene activation and gene inactivation on fat cell phenotype. It is expected that after completing this activity students can:</p>  1<p>Este recurso sirve como complemento al video &quot;PPAR-gamma Activation in the Fat Cell&quot;, un recurso de HHMI BioInteractive. La actividad utiliza PPAR-&gamma; como un ejemplo de regulaci&oacute;n de la transcripci&oacute;n por inhibici&oacute;n negativa, y tambi&eacute;n se puede usar para discutir temas relacionados a se&ntilde;alizaci&oacute;n celular, insulina y diabetes. En la actividad, los estudiantes completar&aacute;n una actividad de colorear donde analizar&aacute;n y organizar&aacute;n los elementos de un gen incluyendo elementos reguladores. Adem&aacute;s, analizar&aacute;n c&oacute;mo un f&aacute;rmaco puede funcionar como un activador en este proceso. Los estudiantes tambi&eacute;n van a comparar y contrastar el efecto de la activaci&oacute;n e inactivaci&oacute;n de genes en el fenotipo de c&eacute;lulas de grasa. Se espera que despu&eacute;s de completar esta actividad los estudiantes puedan:</p>
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3<p>1. Describe examples of regulation of gene expression in eukaryotic cells, including gene regulatory elements on DNA, that effect RNA&nbsp; and protein expression.</p>  3<p>1. Describir ejemplos de regulaci&oacute;n de expresi&oacute;n g&eacute;nica en eucari&oacute;tica a nivel de ADN, ARN y prote&iacute;na.</p>
4  4  
5<p>2. Compare and contrast the mechanisms of regulation of the activation and repression of gene expression in prokaryotes and eukaryotes (assuming instructors may have covered examples such as the <em>lac</em> operon).</p>  5<p>2. Comparar y contrastar los mecanismos de regulaci&oacute;n de la activaci&oacute;n y la repression de la expresi&oacute;n g&eacute;nica en procariotas y eucariotas.</p>
6  6  
7<p>3. Draw the elements of a gene, including the coding area and the regulatory elements.</p>  7<p>3. Dibujar los elementos de un gen , incluida la secuencia de codificaci&oacute;n y los elementos reguladores.</p>
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9<p>4. Understand that genes are differentially expressed in tissues and under different environmental conditions.</p>  9<p>4. Comprender que los genes se expresan diferencialmente en los tejidos y bajo diferentes condiciones ambientales.</p>
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11<p>5. Give examples of the results of changes in regulation on gene expression</p>  11<p>5. Ejemplificar los resultados de los cambios de regulaci&oacute;n de la expresi&oacute;n g&eacute;nica.</p>
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Attachments

1 file — ./Cell and Molecular Group/Regulation of gene expression and adipogenesis by PPAR- INSTRUCTOR GUIDE.pdf 1 file — Cell and Molecular Group/Actividad para estudiantes PPAR GAMMA.pdf
2 file — ./Cell and Molecular Group/Regulation of Gene Expression and Adipogenesis by PPAR-- Student Worksheet.pdf 2 file — Cell and Molecular Group/Guia del Instructor_ Actividad PPAR-GAMMA.pdf
3 link — PPAR-gamma Activation in the Fat Cell | HHMI BioInteractive 3 link — PPAR-gamma Activation in the Fat Cell | HHMI BioInteractive
4 link — DNA transcription (basic detail) | HHMI BioInteractive 4 link — DNA transcription (basic detail) | HHMI BioInteractive
5 file — ./800px-Fries_2.jpg 5 file — publication_1110_1461/800px-Fries_2.jpg
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