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In this classroom activity, students are introduced to the genetics of sickle cell disease by a short film The Making of the Fittest: Natural Selection in Humans . A classroom handout guides students through a series of questions relating the information presented in the film to Mendelian genetics, probability, pedigree analysis, and chi-squared statistics.  

Researchers should cite this work as follows:

• Brokaw, A. (2012). Mendelian Genetics, Probability, Pedigree, and Chi-Squared Statistics. HHMI BioInteractive. Retrieved from http://www.hhmi.org/biointeractive/mendelian-genetics-probability-pedigree-and-chi-square-statistics. 

1. chi-squared
2. genetics
3. in-class activity
4. pedigrees
5. Presentation
6. Probability
7. problem set
8. Resources @ HHMI - BioInteractive
9. Resources @ QUBES - Teaching & Reference