Support

Support Options

  • Knowledge Base

    Find information on common questions and issues.

  • Support Messages

    Check on the status of your correspondences with members of the QUBES team.

Contact Us

About you
About the problem

Tags: C4. Bioinformatics tools

Description

C4. Use bioinformatics tools to examine complex biological problems in evolution, information flow, and other important areas of biology. This competency is written broadly so as to encompass a variety of problems that can be addressed using bioinformatics tools, such as understanding the evolutionary underpinnings of sequence comparison and homology detection; distinguishing between genomic sequences, RNA sequences, and protein sequences; and 
23 interpreting phylogenetic trees. “Complex” biological problems require that students should be able to work through a problem with multiple steps, not just perform isolated tasks. 

  • Using multiple lines of evidence, annotate a gene.
  • Develop and interpret a “tree of life” based on a BLAST search, multiple alignment, and
    phylogenetic-tree building.
  • Explain how a mutation in a gene causes cancer, using a genome browser to identify the gene, transcript, and affected protein, and tools such as OMIM, GO, and KEGG to place it in the context of a function and pathway important to the disease.

All Categories (21-40 of 41)

  1. Teaching RNAseq at Undergraduate Institutions: A tutorial and R package from the Genome Consortium for Active Teaching

    04 Jan 2019 | Teaching Materials | Contributor(s):

    By Mark Phillip Peterson1, Jacob T Malloy2, Vincent P Buonaccorsi2, James H Marden3

    1. Viterbo University 2. Juniata College 3. Pennsylvania State University

    This lesson plan was created to teach RNAseq analysis as a part of GCAT-SEEK network. It is provided here, both in finished form and with the modifiable source code, to allow flexible adaptation to...

    https://qubeshub.org/publications/1005/?v=1

  2. Murder by HIV? Undergraduate edition

    04 Jan 2019 | Teaching Materials | Contributor(s):

    By Naowarat (Ann) Cheeptham1, Laura B. Regassa2, Michèle I. Shuster3

    1. Thompson Rivers University 2. Georgia Southern University 3. New Mexico State University

    Bioinformatics case study focusing on phylogenetic tree interpretation, published in the National Center for Case Study Teaching in Science

    https://qubeshub.org/publications/1004/?v=1

  3. Homologous chromosomes? Exploring human sex chromosomes, sex determination and sex reversal using bioinformatics approaches

    04 Jan 2019 | Teaching Materials | Contributor(s):

    By Kelsey Metzger

    University of Minnesota, Rochester

    In this four- part guided activity, students will learn about the structure and function of human autosomal and sex chromosomes, view and interpret gene maps, and gain familiarity with basic...

    https://qubeshub.org/publications/1000/?v=1

  4. Finding Selection in All the Right Places

    03 Jan 2019 | Teaching Materials | Contributor(s):

    By Juliet F. K. Noor, Mohamed A. F. Noor

    Lab introducing students to evolutionary genetics using bioinformatics and biocuration, published as GSA Learning Resource

    https://qubeshub.org/publications/994/?v=1

  5. Colon Cancer: A Case of Genetic Bad Luck

    03 Jan 2019 | Teaching Materials | Contributor(s):

    By Anne M. Casper

    Eastern Michigan University

    Case study developed for an introductory genetics class published in the National Center for Case Study Teaching in Science

    https://qubeshub.org/publications/992/?v=1

  6. Bioinformatics / Neuroinformatics

    03 Jan 2019 | Teaching Materials | Contributor(s):

    By William Grisham

    University of California, Los Angeles

    This module is a computer-based introduction to bioinformatics resources. This easy-to-adopt module weaves together several important bioinformatic tools so students can grasp how each is used in...

    https://qubeshub.org/publications/990/?v=1

  7. Bioinformatics: An Interactive Introduction to NCBI

    03 Jan 2019 | Teaching Materials | Contributor(s):

    By Seth Bordenstein

    Marine Biological Laboratory

    Modules showing how the NCBI database classifies and organizes information on DNA sequences, evolutionary relationships, and scientific publications. And a module working to identify a nucleotide...

    https://qubeshub.org/publications/989/?v=1

  8. Behavioral Genetics: Investigating the genes of a complex phenotype in fruit flies

    03 Jan 2019 | Teaching Materials | Contributor(s):

    By Craig E. Stanley, Jr., Charles Hadley S. King, IV, Michelle Thornton, Rob J. Kulathinal

    Introductory genetics laboratory published as GSA Learning Resource

    https://qubeshub.org/publications/988/?v=1

  9. The Ames Test

    03 Jan 2019 | Teaching Materials | Contributor(s):

    By Nathan Goodson-Gregg, Elizabeth A. De Stasio

    Introduction to the Ames Test, published as GSA Learning Resource

    https://qubeshub.org/publications/987/?v=1

  10. Bioinformatics - Investigating Sequence Similarity

    04 Dec 2018 | Teaching Materials | Contributor(s):

    By Adam Kleinschmit1, Benita Brink1, Steven Roof2, Carlos Christopher Goller3, Sabrina Robertson3

    1. Adams State University 2. Fairmont State University 3. North Carolina State University

    This laboratory module, leads introductory biology students in the exploration of a basic set of bioinformatics concepts and tools.

    https://qubeshub.org/publications/56/?v=4

  11. Complete Set of Lessons

    01 Nov 2018 | Teaching Materials | Contributor(s):

    By Anne Rosenwald1, Gaurav Arora2, Vinayak Mathur3

    1. Georgetown University 2. Gallaudet University 3. Cabrini University

    The Genome Solver Project began as a way to teach faculty some basic skills in bioinformatics - no coding or scripting. These Lessons also work well in the undergraduate classroom, culminating with...

    https://qubeshub.org/publications/860/?v=1

  12. Using DNA Subway to Analyze Sequence Relationships

    28 May 2018 | Teaching Materials | Contributor(s):

    By Jason Williams1, Ray A. Enke2, Oliver Hyman2, Emily Lescak3, Sam S Donovan4, William Tapprich5, Elizabeth F Ryder6

    1. DNA Learning Center 2. The Department of Biology, James Madison University; The Center for Genome & Metagenome Studies, James Madison University 3. University of Alaska 4. University of Pittsburgh 5. University of Nebraska-Omaha 6. Worcester Polytechnic Institute

    This is a bioinformatics exercise using the DNA Subway Blue Line, a user-friendly pipeline of bioinformatics tools, to analyze a collection of mosquito DNA bar-code sequences.

    https://qubeshub.org/publications/165/?v=2

  13. DNA Subway Learning Resources

    18 Oct 2017 | Teaching Materials | Contributor(s):

    By Jason Williams

    DNA Learning Center

    DNA Subway is a NIBLSE Recommended resource. This is a collection of learning resources associated with DNA Subway.

    https://qubeshub.org/publications/164/?v=2

  14. Using DNA Subway to Analyze Sequence Relationships

    18 Oct 2017 | Teaching Materials | Contributor(s):

    By Jason Williams

    DNA Learning Center

    This is a bioinformatics exercise using DNA Subway

    https://qubeshub.org/publications/165/?v=1

  15. Bioinformatics - Investigating Sequence Similarity

    05 Jul 2017 | Teaching Materials | Contributor(s):

    By Adam Kleinschmit1, Benita Brink1, Steven Roof2, Komal Vig3, Carlos Christopher Goller4, Sabrina Robertson5

    1. Adams State University 2. Hampshire College 3. Alabama State University 4. North Carolina State University 5. NC State

    This laboratory module, leads introductory biology students in the exploration of a basic set of bioinformatics concepts and tools.

    https://qubeshub.org/publications/56/?v=3

  16. Bioinformatics - Investigating Sequence Similarity

    05 Jun 2017 | Teaching Materials | Contributor(s):

    By Adam Kleinschmit1, Benita Brink1, Steven Roof2, Komal Vig3

    1. Adams State University 2. Hampshire College 3. Alabama State University

    This laboratory module, leads introductory biology students in the exploration of a basic set of bioinformatics concepts and tools.

    https://qubeshub.org/publications/56/?v=2

  17. Exploring HIV Evolution

    05 Jun 2017 | Teaching Materials | Contributor(s):

    By Sam S Donovan1, Tony Weisstein2

    1. University of Pittsburgh 2. Truman State University

    In this activity you will study aspects of sequence evolution by working with a set of HIV sequence data from 15 different subjects (Markham, et al., 1998). You will first learn about the dataset,...

    https://qubeshub.org/publications/24/?v=2

  18. RNA-seq Analysis

    05 Jun 2017 | Teaching Materials | Contributor(s):

    By Bill Morgan1, Matthew Reeder2

    1. The College of Wooster 2. Ohio State University

    In this computer lab module, students learn how to process an RNA-seq data set to identify differentially expressed genes (DEGs). The samples for this data set were collected from yeast cells...

    https://qubeshub.org/publications/27/?v=2

  19. Bioinformatics - Investigating Sequence Similarity

    31 Jan 2017 | Teaching Materials | Contributor(s):

    By Adam Kleinschmit1, Benita Brink1, Steven Roof2, Komal Vig3

    1. Adams State University 2. Hampshire College 3. Alabama State University

    This laboratory module, leads introductory biology students in the exploration of a basic set of bioinformatics concepts and tools.

    https://qubeshub.org/publications/56/?v=1

  20. Exploring HIV Evolution

    05 Aug 2016 | Teaching Materials | Contributor(s):

    By Sam S Donovan1, Tony Weisstein2

    1. University of Pittsburgh 2. Truman State University

    In this activity you will study aspects of sequence evolution by working with a set of HIV sequence data from 15 different subjects (Markham, et al., 1998). You will first learn about the dataset,...

    https://qubeshub.org/publications/24/?v=1