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Tags: C4. Bioinformatics tools


C4. Use bioinformatics tools to examine complex biological problems in evolution, information flow, and other important areas of biology. This competency is written broadly so as to encompass a variety of problems that can be addressed using bioinformatics tools, such as understanding the evolutionary underpinnings of sequence comparison and homology detection; distinguishing between genomic sequences, RNA sequences, and protein sequences; and 
23 interpreting phylogenetic trees. “Complex” biological problems require that students should be able to work through a problem with multiple steps, not just perform isolated tasks. 

  • Using multiple lines of evidence, annotate a gene.
  • Develop and interpret a “tree of life” based on a BLAST search, multiple alignment, and
    phylogenetic-tree building.
  • Explain how a mutation in a gene causes cancer, using a genome browser to identify the gene, transcript, and affected protein, and tools such as OMIM, GO, and KEGG to place it in the context of a function and pathway important to the disease.

All Categories (41-41 of 41)

  1. RNA-seq Analysis

    03 Aug 2016 | Teaching Materials | Contributor(s):

    By Bill Morgan1, Matthew Reeder2

    1. The College of Wooster 2. Ohio State University

    In this computer lab module, students learn how to process an RNA-seq data set to identify differentially expressed genes (DEGs). The samples for this data set were collected from yeast cells...