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  1. A Case of Severe Insulin Resistance

    12 Jun 2020 | Teaching Materials | Contributor(s):

    By Melanie Lenahan1, Shuchismita Dutta2

    1. Raritan Valley Community College 2. RCSB Protein Data Bank, Rutgers University

    This case focuses on understanding how a mutation in a cell signalling protein (a kinase) can prevent insulin function and lead to diabetes.

    https://qubeshub.org/publications/1911/?v=1

  2. COVID-19: Molecular Basis Infection Revisited One Year into the Pandemic

    09 Jun 2021 | Teaching Materials | Contributor(s):

    By Didem Vardar-Ulu

    Boston University, Chemistry Department

    This adaptation was written in Spring 2021 exactly one year after the original case and includes explorations of the emerging mutations within the spike protein

    https://qubeshub.org/publications/2424/?v=1

  3. COVID-19: Molecular Basis of Infection

    12 Jun 2020 | Teaching Materials | Contributor(s):

    By Didem Vardar-Ulu1, Shuchismita Dutta2

    1. Boston University 2. RCSB Protein Data Bank, Rutgers University

    This case was written in Spring 2020 during the COVID-19 pandemic. It focuses on understanding the structure and interaction of the SARS-Cov-2 viral spike protein that facilitates infection in...

    https://qubeshub.org/publications/1912/?v=1

  4. COVID-19: Molecular Basis of Infection-ADAPTATION

    17 Jun 2020 | Teaching Materials | Contributor(s):

    By Didem Vardar-Ulu

    Boston University, Chemistry Department

    This case was written in Spring 2020 during the COVID-19 pandemic. It focuses on understanding the structure and interaction of the SARS-Cov-2 viral spike protein that facilitates infection in...

    https://qubeshub.org/publications/1936/?v=1

  5. COVID-19: On the way to a vaccine

    13 Jun 2020 | Teaching Materials | Contributor(s):

    By Nik Tsotakos

    Penn State Harrisburg

    This multi-part case study introduces the reader to the SARS-CoV-2 virus origins, the molecular basis of the infection, the development and severity of symptoms, and treatment.

    https://qubeshub.org/publications/1918/?v=1

  6. CRISPR Gene Editing: Designing the gRNA and Donor Template

    15 Jul 2020 | Teaching Materials | Contributor(s):

    By Laurel Lorenz

    Princeton

    In this adaptation, students learn how CRISPR/Cas9 is used in bacterial immunity and gene editing. Students create both a gRNA target and a donor template to edit a gene. Mutations can be from the...

    https://qubeshub.org/publications/1962/?v=1

  7. Evolution of Caffeine Biosynthesis Enzymes

    12 Jun 2020 | Teaching Materials | Contributor(s):

    By Brian Sullivan1, Shuchismita Dutta2

    1. University of North Carolina 2. RCSB Protein Data Bank, Rutgers University

    This case focuses on exploring why plants make secondary metabolites like caffeine and how the enzymes required for making caffeine evolved.

    https://qubeshub.org/publications/1909/?v=1

  8. Gigi B. Ray

    https://qubeshub.org/community/members/7229

  9. Happy Blue Baby

    11 Jun 2020 | Teaching Materials | Contributor(s):

    By Shuchismita Dutta

    RCSB Protein Data Bank, Rutgers University

    This case, about a specific mutant of hemoglobin, focuses on visualizing and understanding the molecular basis of why an infant turned blue soon after birth and how the cyanosis resolved on its own...

    https://qubeshub.org/publications/1902/?v=1

  10. Happy Blue Baby

    09 Jun 2021 | Teaching Materials | Contributor(s):

    By Didem Vardar-Ulu

    Boston University, Chemistry Department

    This case, about a specific mutant of hemoglobin, focuses on visualizing and understanding the molecular basis of why an infant turned blue soon after birth and how the cyanosis resolved on its own...

    https://qubeshub.org/publications/2419/?v=1

  11. Happy Blue Baby: MCQs for large classes

    18 May 2021 | Teaching Materials | Contributor(s):

    By "KP" Kristen Procko

    The University of Texas at Austin

    Multiple choice questions for the Happy Blue Baby case study pre-work

    https://qubeshub.org/publications/2381/?v=1

  12. Marina E Tourlakis

    https://qubeshub.org/community/members/32610

  13. Mol* Adaptation: Case of Severe Insulin Resistance

    23 Jul 2021 | Teaching Materials | Contributor(s):

    By Keith A. Johnson

    Bradley University College of Liberal Arts and Sciences

    This is an adaptation using Mol* on the original case written. This case focuses on understanding how a mutation in a cell signalling protein (a kinase) can prevent insulin function and lead to...

    https://qubeshub.org/publications/2483/?v=1

  14. Molecular Basis of Sickle Cell Disease

    15 Jun 2020 | Teaching Materials | Contributor(s):

    By Didem Vardar-Ulu

    Boston University, Chemistry Department

    This multi part case on hemoglobin structure as it relates to oxygen binding and sickle cell disease focuses on utilizing bioinformatics and molecular visualization tools to learn about the sickle...

    https://qubeshub.org/publications/1925/?v=1

  15. Molecular Case Studies

    Collections | 13 Jul 2019 | Posted by Shuchismita Dutta

    https://qubeshub.org/community/groups/summer2019/collections/data-science-in-biology

  16. Nicholas' Story

    11 Jun 2020 | Teaching Materials | Contributor(s):

    By Shuchismita Dutta1, Kimberly Linenberger Cortes2, Henry Vincent Jakubowski3, Melanie Lenahan4, David Marcey5, Pat Marsteller6, Cassidy Terrell7

    1. RCSB Protein Data Bank, Rutgers University 2. Kennesaw State University 3. College of Saint Benedict/Saint John's University 4. Raritan Valley Community College 5. California Lutherian University 6. Emory University 7. University of Minnesota, Rocester

    This 3 part case on sickle cell disease focuses on visualizing and understanding the molecular basis of its cause, symptoms, complications, management, treatment, and possible cures.

    https://qubeshub.org/publications/1907/?v=1

  17. Nicholas' Story

    13 Jun 2020 | Teaching Materials | Contributor(s):

    By Nik Tsotakos

    Penn State Harrisburg

    This 3 part case on sickle cell disease focuses on visualizing and understanding the molecular basis of its cause, symptoms, complications, management, treatment, and possible cures.

    https://qubeshub.org/publications/1919/?v=1

  18. Piwi Matters

    12 Jun 2020 | Teaching Materials | Contributor(s):

    By Laurel Lorenz1, Shuchismita Dutta2

    1. Princeton University 2. RCSB Protein Data Bank, Rutgers University

    This case focuses on understanding structure and function relationships in Piwi, a protein that is critical for germline stem cell function and development of eggs in the fruit fly ovary.

    https://qubeshub.org/publications/1910/?v=1

  19. Shuchismita Dutta

    I am a structural biologist, dedicated to promoting a molecular view of biology. I enjoy visualizing biomolecular structures, learning about their interactions and understanding their functions in...

    https://qubeshub.org/community/members/5730

  20. The Happy Blue Baby Hemoglobin

    14 Jun 2020 | Teaching Materials | Contributor(s):

    By Kasandra Jean-Louise Riley1, Shuchismita Dutta2

    1. Rollins College 2. RCSB Protein Data Bank, Rutgers University

    This case, about a specific mutant of hemoglobin, focuses on visualizing and understanding the molecular basis of why an infant turned blue soon after birth and how the cyanosis resolved.

    https://qubeshub.org/publications/1924/?v=1

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