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  1. Garden Variety Mutations: Using Primary Data to Understand the Central Dogma in Large-Lecture Introductory Biology

    22 Nov 2022 | Teaching Materials | Contributor(s):

    By Jacob Woodbury†1, Jessie B. Arneson†2, Jacey Anderson1, Larry Collins3, Andy Cavagnetto1, William Davis1, Erika G. Offerdahl*1

    1. Washington State University 2. University of Jamestown 3. Delta State University

    The ability to interpret and create an argument from data is a crucial skill for budding scientists, yet one that is seldom practiced in introductory courses. During this argumentation module,...

    https://qubeshub.org/publications/3559/?v=1

  2. A Muscular Dystrophy Case Study Illustrating the Phenotypic Effects of Mutation

    31 Oct 2022 | Teaching Materials | Contributor(s):

    By Lauren J. Hodkinson†1, Julia L. Gross†2, Leila E. Rieder*1

    1. Emory University 2. Emory University, National Institute of Allergy and Infectious Disease

    Mutations in genes can lead to a variety of phenotypes, including various human diseases. Students often understand that a particular mutation in a single gene causes a disease phenotype, but it is...

    https://qubeshub.org/publications/3558/?v=1

  3. A Rapid Genetic Screen Using Wisconsin Fast Plants®: A Hands-On Approach to Inheritance of de novo Mutations

    03 Oct 2022 | Teaching Materials | Contributor(s):

    By Amy L. Klocko*

    University of Colorado Colorado Springs, Colorado Springs

    Some concepts in genetics, such as genetic screens, are complex for students to visualize in a classroom and can be cumbersome to undertake in the laboratory. Typically, very large populations are...

    https://qubeshub.org/publications/3509/?v=1

  4. Application of a Bacterial Experimental Evolution System to Visualize and Teach Evolution in Action: A Course-Based Undergraduate Research Experience

    09 Aug 2022 | Teaching Materials | Contributor(s):

    By Collin Kessler1, William Mazza1, Kasey Christopher1, Wook Kim*1

    Duquesne University

    Concepts of evolution are typically taught through examples of extremely long timescales, which do not always resonate broadly. Here, we describe a course-based undergraduate research experience...

    https://qubeshub.org/publications/3422/?v=1

  5. Metastatic Mastery: A Case and Game-Based Approach to Learning About Cancer Mechanisms

    07 Aug 2022 | Teaching Materials | Contributor(s):

    By Sayali Kukday*1, Emilyn Frohn2, Alice Paige3

    1. Iowa State University 2. Biomedical Animator 3. Fiction Author and Essayist

    Mechanisms that contribute to the development of cancer are numerous and complicated, though most can be traced to a set of mutations in cell cycle regulatory genes that throw the process of cell...

    https://qubeshub.org/publications/3420/?v=1

  6. Converting a Face-to-Face Lab to Online: An Example of Process and Outcomes for a CRISPR-Based Molecular Biology Lab

    30 Aug 2021 | Teaching Materials | Contributor(s):

    By Lisa M. McDonnell #*1, Keefe Reuther #1, Andrew Cooper1, Christopher Day1, Cindy Gustafson-Brown1

    University of California, San Diego

    The COVID-19 pandemic created a need to convert in-person laboratory courses into an online format in a short amount of time. For this reason, we converted our face-to-face molecular biology lab...

    https://qubeshub.org/publications/2731/?v=1

  7. GMC: Genes, Mutations and Cancer - Group Concept Map Development

    28 Aug 2021 | Teaching Materials | Contributor(s):

    By Shoshana D. Katzman*1, John H. Horne2, Sonu S. Baral3, Keith P. Choe4, Elizabeth Eich5

    1. Georgia Gwinnett College 2. University of New Orleans 3. Louisiana State University 4. University of Florida 5. Rice University

    It has been shown that active learning strategies used in the classroom can increase student learning and retention of information. We generated an active learning exercise that can be used in the...

    https://qubeshub.org/publications/2736/?v=1

  8. Linking Genotype to Phenotype: The Effect of a Mutation in Gibberellic Acid Production on Plant Germination

    27 Aug 2021 | Teaching Materials | Contributor(s):

    By James W. Mann1, Jennifer Larson2, Marcelo Pomeranz1, Emma M. Knee1, Diana Shin1, Julie A. Miller1, Courtney G. Price1, Deborah K. Crist1, Erich Grotewold1, Jelena Brkljacic1

    1. The Ohio State University 2. Capital University

    Basic concepts in genetics and plant development are often taught in lecture courses without a lab component. This approach provides students with the content knowledge, but fails to make...

    https://qubeshub.org/publications/2596/?v=1

  9. A clicker-based case study that untangles student thinking about the processes in the central dogma

    27 Aug 2021 | Teaching Materials | Contributor(s):

    By Karen Nicole Pelletreau1, Tessa Andrews2, Norris Armstrong2, Mary A Bedell2, Farahad Dastoor1, Neta Dean3, Susan Erster3, Cori Fata-Hartley4, Nancy Guild5, Hamish Greig1, David Hall2, Jennifer K Knight5, Donna Koslowsky4, Paula Lemons2, Jennifer Martin5, Jill McCourt2, John Merrill4, Rosa Moscarella4, Ross Nehm3, Robert Northington1, Brian Olsen1, Luanna Prevost6, Jon Stolzfus4, Mark Urban-Lurain4, Michelle K. Smith1

    1. University of Maine 2. University of Georgia 3. Stony Brook University 4. Michigan State University 5. University of Colorado Boulder 6. University of South Florida

    The central dogma of biology is a foundational concept that provides a scaffold to understand how genetic information flows in biological systems. Despite its importance, undergraduate students...

    https://qubeshub.org/publications/2577/?v=1

  10. Predicting and classifying effects of insertion and deletion mutations on protein coding regions

    26 Aug 2021 | Teaching Materials | Contributor(s):

    By Joseph Ross

    California State University, Fresno

    Mutations in genes can affect the encoded proteins in multiple ways, and some of these effects are counterintuitive. As for any other knowledge, students must create their own deep understanding of...

    https://qubeshub.org/publications/2569/?v=1

  11. Happy Blue Baby

    09 Jun 2021 | Teaching Materials | Contributor(s):

    By Didem Vardar-Ulu

    Boston University, Chemistry Department

    This case, about a specific mutant of hemoglobin, focuses on visualizing and understanding the molecular basis of why an infant turned blue soon after birth and how the cyanosis resolved on its own...

    https://qubeshub.org/publications/2419/?v=1

  12. Happy Blue Baby: MCQs for large classes

    18 May 2021 | Teaching Materials | Contributor(s):

    By "KP" Kristen Procko

    The University of Texas at Austin

    Multiple choice questions for the Happy Blue Baby case study pre-work

    https://qubeshub.org/publications/2381/?v=1

  13. CRISPR Gene Editing: Designing the gRNA and Donor Template

    15 Jul 2020 | Teaching Materials | Contributor(s):

    By Laurel Lorenz

    Princeton

    In this adaptation, students learn how CRISPR/Cas9 is used in bacterial immunity and gene editing. Students create both a gRNA target and a donor template to edit a gene. Mutations can be from the...

    https://qubeshub.org/publications/1962/?v=1

  14. The Happy Blue Baby Hemoglobin

    14 Jun 2020 | Teaching Materials | Contributor(s):

    By Kasandra Jean-Louise Riley1, Shuchismita Dutta2

    1. Rollins College 2. RCSB Protein Data Bank, Rutgers University

    This case, about a specific mutant of hemoglobin, focuses on visualizing and understanding the molecular basis of why an infant turned blue soon after birth and how the cyanosis resolved.

    https://qubeshub.org/publications/1924/?v=1

  15. Happy Blue Baby

    11 Jun 2020 | Teaching Materials | Contributor(s):

    By Shuchismita Dutta

    RCSB Protein Data Bank, Rutgers University

    This case, about a specific mutant of hemoglobin, focuses on visualizing and understanding the molecular basis of why an infant turned blue soon after birth and how the cyanosis resolved on its own...

    https://qubeshub.org/publications/1902/?v=1

  16. Exploring Random Mutation and Selection: Avida-Ed Lab Book Exercise 2

    17 May 2020 | Teaching Materials | Contributor(s):

    By Amy Lark, Cory Kohn1, Jim Smith1, Louise Mead2, Robert T Pennock1, Wendy Johnson

    1. Michigan State University 2. BEACON Center for the Study of Evolution in Action

    An introductory activity exploring the role of random mutation in natural selection using the Avida-ED simulation.

    https://qubeshub.org/publications/1847/?v=1

  17. Exploring the Introduction of Genetic Variation by Random Mutation: Avida-Ed Lab Book Exercise 1

    17 May 2020 | Teaching Materials | Contributor(s):

    By Cory Kohn1, Amy Lark, Jim Smith2, Louise Mead3, Robert T Pennock2, Wendy Johnson

    1. Keck Science Department, The Claremont Colleges 2. Michigan State University 3. BEACON Center for the Study of Evolution in Action

    An introductory activity introducing the role of random mutation in generating genetic variation using the Avida-ED simulation.

    https://qubeshub.org/publications/1840/?v=1

  18. Selection and the Blond Beach Mouse

    12 Nov 2018 | Teaching Materials | Contributor(s):

    By Joan Sharp

    Simon Fraser University

    National Center for Case Study Teaching in Science- this "clicker" case study explores ultimate and proximate explanations for cryptic coloration in animals.

    https://qubeshub.org/publications/921/?v=1

  19. Mutation and Selection: An Exploration of Antibiotic Resistance in Serratia Marcescens

    25 Oct 2018 | Teaching Materials | Contributor(s):

    By Laurel Hester1, Mark Sarvary2, Corey Ptak

    1. Keuka College 2. Cornell University

    This laboratory module gives students hands-on experience with mutation and selection in bacteria.

    https://qubeshub.org/publications/875/?v=1

  20. Joel E. Greengiant Learns About Peas: From Nucleotides to Selection

    23 Oct 2018 | Teaching Materials | Contributor(s):

    By Merle Heidemann1, Peter J.T. White1, Jim Smith1

    Michigan State University

    This case study follows purveyors of peas, Joel E. and Jolene Greengiant, as they learn about the origin, biochemistry, genetics and eventual artificial selection of sweet (wrinkled) peas, all in...

    https://qubeshub.org/publications/845/?v=1

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