Network for Integrating Bioinformatics into Life Sciences Education: Resources

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Using Bioinformatics to Understand Genetic Diseases: A Practical Guide

This Practical Guide outlines a number of basic bioinformatics approaches that can be used to understand the molecular basis of genetic diseases.

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Using computational molecular modeling software to demonstrate how DNA mutations cause phenotypes

This lesson is a five-week series of laboratory activities designed to help students transition from applying lower order thinking skills to the central dogma to applying higher-order thinking skills.

Keywords: bioinformaticsNIBLSEProtein StructureDNAmolecular modelinggenotypephenotypeCourseSourcecomputational modelingcentral dogmaplant leaf structure

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A Critical Guide to the PDB

This Critical Guide in the Introduction to Bioinformatics series provides a brief outline of the Protein Data Bank – the PDB – the world’s primary repository of biological macromolecular structures.

Keywords: NIBLSEGOBLETInstructorResources

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A Critical Guide to the UniProtKB Flat-file Format

This Critical Guide briefly presents the need for biological databases and for a standard format for storing and organising biological data.

Keywords: NIBLSEuniprotGOBLETInstructorResources

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Homologous chromosomes? Exploring human sex chromosomes, sex determination and sex reversal using bioinformatics approaches

In this four- part guided activity, students will learn about the structure and function of human autosomal and sex chromosomes, view and interpret gene maps, and gain familiarity with basic...

Keywords: bioinformaticsNIBLSECourseSourceautosomehomologous chromosomeshomologous recombinationsex chromosomesex determinationsex reversal mutations

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Bioinformatics: Investigating Sequence Similarity - A Plant Biology Approach

This laboratory module is a modification of the original published on CourseSource with a focus on plant biology. In the final activity, students conduct a BLAST to compare histone protein...

Keywords: phylogeneticsbioinformaticssequencingFASTANCBIplant biologyNIBLSEalgorithmsincubatorsPlant and Fungal EvolutionBLASTmultiple sequence alignmentsequence similarityBLOSUM scoring matrixneighbor-joining distance matrixCourseSourcephylogram

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Inquiry-based hypothesis testing using phylogenetic trees in MEGA

A key learning objective in biology is applying bioinformatics tools to test a real-life question. These inquiry-based modules have students assemble and align data, and construct simple...

Keywords: phylogeneticsbioinformaticsFASTANCBIBLASTmultiple sequence alignmentsequence similarityCourseSourceZika virusMEGAalcohol metabolism

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A Hands-on Introduction to Hidden Markov Models

A lesson in which students will understand the basic structure of an HMM, the types of data used in ab initio gene prediction, and its consequent limitations.

Keywords: Markov modelbioinformaticsgenomicsNIBLSEtranscriptionCourseSourceexonintronsplicing

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376

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Behavioral Genetics: Investigating the genes of a complex phenotype in fruit flies

Introductory genetics laboratory published as GSA Learning Resource

Keywords: behaviorbioinformaticsNIBLSEdrosophilagenetic basisfruit fliesmodel organism

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Resources

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Want to find additional resources? Browse resources on QUBES!
QUBES hosts not only the resources shown here, but many more created by the broader QUBES community.