The NIBLSE community is coordinating an effort to collect, customize, and disseminate high quality bioinformatics learning resources. Below is collection of Bioinformatics Learning Resources including NIBLSE Incubators and CourseSource Bioinformatics resources.
NIBLSE is working with the Quantitative Undergraduate Biology Education & Synthesis Project (QUBES) to establish learning resource “incubators” to nurture the development and dissemination of promising lesson materials.
NIBLSE is working with the CourseSource Project to articulate a Learning Framework for Bioinformatics which describes the learning goals and objectives relevant to undergraduate biological sciences majors.
All learning resources have been reviewed and assigned NIBLSE Core Competencies. To see a full description, click the competency or visit the NIBLSE Core Competency page.
Click the icon to the right to download a guide on how to navigate a QUBES Database: 
Browse the Collection by Card
C1. Role of Bioinformatics C2. Computational Concepts C3. Statistical Concepts C4. Bioinformatics Tools
C5. Data Retrieval C6. Model C7. Scripting C8. Data Types C9. Implications
C1
In this lesson, we describe an easily adaptable lab module that can be used in existing undergraduate molecular biology lab courses to conduct authentic scientific research, published in CourseSource
This lesson plan was created to teach RNAseq analysis as a part of GCAT-SEEK network. It is provided here, both in finished form and with the modifiable source code, to allow flexible adaptation to various classroom settings, published in CourseSource
Lesson on what it means for biological processes to be Poissonian, published in CourseSource
In this four- part guided activity, students will learn about the structure and function of human autosomal and sex chromosomes, view and interpret gene maps, and gain familiarity with basic bioinformatics resources and data through use of the National Ce
Bioinformatics / Neuroinformatics
Version: 1.0
This module is a computer-based introduction to bioinformatics resources. This easy-to-adopt module weaves together several important bioinformatic tools so students can grasp how each is used in answering research questions. Published in CBE-LSE
Bioinformatics: An Interactive Introduction to NCBI
Version: 1.0
Modules showing how the NCBI database classifies and organizes information on DNA sequences, evolutionary relationships, and scientific publications. And a module working to identify a nucleotide sequence from an insect endosymbiont by using BLAST
Introductory genetics laboratory published as GSA Learning Resource
Using DNA Subway to Analyze Sequence Relationships
Version: 2.0
This is a bioinformatics exercise using the DNA Subway Blue Line, a user-friendly pipeline of bioinformatics tools, to analyze a collection of mosquito DNA bar-code sequences.
RNAseq data analysis using Galaxy
Version: 3.0
This is a bioinformatics exercise intended for use in a computer lab setting with life science majors.
Wolf Sheep Predation Simulation Exercise
Version: 2.0
This resource is an exercise to introduce students to agent-based modeling of biological systems through working with a simple existing model.
Exploring HIV Evolution
Version: 2.0
In this activity you will study aspects of sequence evolution by working with a set of HIV sequence data from 15 different subjects (Markham, et al., 1998). You will first learn about the dataset, then study the possible sources of HIV for these...
C2
This lesson plan was created to teach RNAseq analysis as a part of GCAT-SEEK network. It is provided here, both in finished form and with the modifiable source code, to allow flexible adaptation to various classroom settings, published in CourseSource
Module using analogies to introduce students to genomics
A Hands-on Introduction to Hidden Markov Models
Version: 1.0
A lesson in which students will understand the basic structure of an HMM, the types of data used in ab initio gene prediction, and its consequent limitations.
Bioinformatics / Neuroinformatics
Version: 1.0
This module is a computer-based introduction to bioinformatics resources. This easy-to-adopt module weaves together several important bioinformatic tools so students can grasp how each is used in answering research questions. Published in CBE-LSE
Bioinformatics - Investigating Sequence Similarity
Version: 4.0
This laboratory module, leads introductory biology students in the exploration of a basic set of bioinformatics concepts and tools.
Using DNA Subway to Analyze Sequence Relationships
Version: 2.0
This is a bioinformatics exercise using the DNA Subway Blue Line, a user-friendly pipeline of bioinformatics tools, to analyze a collection of mosquito DNA bar-code sequences.
RNAseq data analysis using Galaxy
Version: 3.0
This is a bioinformatics exercise intended for use in a computer lab setting with life science majors.
Needleman - Wunsch Algorithm Exercise
Version: 3.0
This exercise is used in a sophomore-junior level bioinformatics course. The algorithm is introduced to the students who then complete the exercise.
C3
This lesson plan was created to teach RNAseq analysis as a part of GCAT-SEEK network. It is provided here, both in finished form and with the modifiable source code, to allow flexible adaptation to various classroom settings, published in CourseSource
Lesson on what it means for biological processes to be Poissonian, published in CourseSource
A Hands-on Introduction to Hidden Markov Models
Version: 1.0
A lesson in which students will understand the basic structure of an HMM, the types of data used in ab initio gene prediction, and its consequent limitations.
Finding Selection in All the Right Places
Version: 1.0
Lab introducing students to evolutionary genetics using bioinformatics and biocuration, published as GSA Learning Resource
Bioinformatics / Neuroinformatics
Version: 1.0
This module is a computer-based introduction to bioinformatics resources. This easy-to-adopt module weaves together several important bioinformatic tools so students can grasp how each is used in answering research questions. Published in CBE-LSE
RNAseq data analysis using Galaxy
Version: 3.0
This is a bioinformatics exercise intended for use in a computer lab setting with life science majors.
C4
In this lesson, we describe an easily adaptable lab module that can be used in existing undergraduate molecular biology lab courses to conduct authentic scientific research, published in CourseSource
Using computational molecular modeling software to demonstrate how DNA mutations cause phenotypes
Version: 1.0
This lesson is a five-week series of laboratory activities designed to help students transition from applying lower order thinking skills to the central dogma to applying higher-order thinking skills.
This lesson plan was created to teach RNAseq analysis as a part of GCAT-SEEK network. It is provided here, both in finished form and with the modifiable source code, to allow flexible adaptation to various classroom settings, published in CourseSource
Murder by HIV? Undergraduate edition
Version: 1.0
Bioinformatics case study focusing on phylogenetic tree interpretation, published in the National Center for Case Study Teaching in Science
In this four- part guided activity, students will learn about the structure and function of human autosomal and sex chromosomes, view and interpret gene maps, and gain familiarity with basic bioinformatics resources and data through use of the National Ce
Finding Selection in All the Right Places
Version: 1.0
Lab introducing students to evolutionary genetics using bioinformatics and biocuration, published as GSA Learning Resource
Colon Cancer: A Case of Genetic Bad Luck
Version: 1.0
Case study developed for an introductory genetics class published in the National Center for Case Study Teaching in Science
Bioinformatics / Neuroinformatics
Version: 1.0
This module is a computer-based introduction to bioinformatics resources. This easy-to-adopt module weaves together several important bioinformatic tools so students can grasp how each is used in answering research questions. Published in CBE-LSE
Bioinformatics: An Interactive Introduction to NCBI
Version: 1.0
Modules showing how the NCBI database classifies and organizes information on DNA sequences, evolutionary relationships, and scientific publications. And a module working to identify a nucleotide sequence from an insect endosymbiont by using BLAST
Introductory genetics laboratory published as GSA Learning Resource
The Ames Test
Version: 1.0
Introduction to the Ames Test, published as GSA Learning Resource
Bioinformatics - Investigating Sequence Similarity
Version: 4.0
This laboratory module, leads introductory biology students in the exploration of a basic set of bioinformatics concepts and tools.
BSL-4: Authorized Personnel Only
Version: 1.0
National Center for Case Study Teaching in Science resource on the 2014 Ebola epidemic. This resource is also included in the NIBLSE Learning Resource Collection
Using DNA Subway to Analyze Sequence Relationships
Version: 2.0
This is a bioinformatics exercise using the DNA Subway Blue Line, a user-friendly pipeline of bioinformatics tools, to analyze a collection of mosquito DNA bar-code sequences.
Exploring HIV Evolution
Version: 2.0
In this activity you will study aspects of sequence evolution by working with a set of HIV sequence data from 15 different subjects (Markham, et al., 1998). You will first learn about the dataset, then study the possible sources of HIV for these...
RNA-seq Analysis
Version: 2.0
In this computer lab module, students learn how to process an RNA-seq data set to identify differentially expressed genes (DEGs). The samples for this data set were collected from yeast cells expressing either a control gene or a pathogen...
C5
In this lesson, we describe an easily adaptable lab module that can be used in existing undergraduate molecular biology lab courses to conduct authentic scientific research, published in CourseSource
Using computational molecular modeling software to demonstrate how DNA mutations cause phenotypes
Version: 1.0
This lesson is a five-week series of laboratory activities designed to help students transition from applying lower order thinking skills to the central dogma to applying higher-order thinking skills.
This lesson plan was created to teach RNAseq analysis as a part of GCAT-SEEK network. It is provided here, both in finished form and with the modifiable source code, to allow flexible adaptation to various classroom settings, published in CourseSource
Murder by HIV? Undergraduate edition
Version: 1.0
Bioinformatics case study focusing on phylogenetic tree interpretation, published in the National Center for Case Study Teaching in Science
Finding Selection in All the Right Places
Version: 1.0
Lab introducing students to evolutionary genetics using bioinformatics and biocuration, published as GSA Learning Resource
To increase students' interest in their own genomes, this computer-based laboratory lesson is designed to be coupled with the opportunity for the students to be genotyped by the consumer sequencing company, 23andMe. Published in CourseSource
Colon Cancer: A Case of Genetic Bad Luck
Version: 1.0
Case study developed for an introductory genetics class published in the National Center for Case Study Teaching in Science
Bioinformatics / Neuroinformatics
Version: 1.0
This module is a computer-based introduction to bioinformatics resources. This easy-to-adopt module weaves together several important bioinformatic tools so students can grasp how each is used in answering research questions. Published in CBE-LSE
Bioinformatics: An Interactive Introduction to NCBI
Version: 1.0
Modules showing how the NCBI database classifies and organizes information on DNA sequences, evolutionary relationships, and scientific publications. And a module working to identify a nucleotide sequence from an insect endosymbiont by using BLAST
Introductory genetics laboratory published as GSA Learning Resource
The Ames Test
Version: 1.0
Introduction to the Ames Test, published as GSA Learning Resource
Bioinformatics - Investigating Sequence Similarity
Version: 4.0
This laboratory module, leads introductory biology students in the exploration of a basic set of bioinformatics concepts and tools.
BSL-4: Authorized Personnel Only
Version: 1.0
National Center for Case Study Teaching in Science resource on the 2014 Ebola epidemic. This resource is also included in the NIBLSE Learning Resource Collection
Using DNA Subway to Analyze Sequence Relationships
Version: 2.0
This is a bioinformatics exercise using the DNA Subway Blue Line, a user-friendly pipeline of bioinformatics tools, to analyze a collection of mosquito DNA bar-code sequences.
RNAseq data analysis using Galaxy
Version: 3.0
This is a bioinformatics exercise intended for use in a computer lab setting with life science majors.
RNA-seq Analysis
Version: 2.0
In this computer lab module, students learn how to process an RNA-seq data set to identify differentially expressed genes (DEGs). The samples for this data set were collected from yeast cells expressing either a control gene or a pathogen...
C6
Bioinformatics / Neuroinformatics
Version: 1.0
This module is a computer-based introduction to bioinformatics resources. This easy-to-adopt module weaves together several important bioinformatic tools so students can grasp how each is used in answering research questions. Published in CBE-LSE
Wolf Sheep Predation Simulation Exercise
Version: 2.0
This resource is an exercise to introduce students to agent-based modeling of biological systems through working with a simple existing model.
C7
This lesson plan was created to teach RNAseq analysis as a part of GCAT-SEEK network. It is provided here, both in finished form and with the modifiable source code, to allow flexible adaptation to various classroom settings, published in CourseSource
An Introduction to the R Programming Environment
Version: 1.0
An online module introducing students and biologists to R, published in American Phytopathological Society
Introduction to UNIX command line
Version: 1.0
These are materials for a Unix workshop with hands-on examples that requires no prior knowledge of Unix or programming.
C8
In this lesson, we describe an easily adaptable lab module that can be used in existing undergraduate molecular biology lab courses to conduct authentic scientific research, published in CourseSource
This lesson plan was created to teach RNAseq analysis as a part of GCAT-SEEK network. It is provided here, both in finished form and with the modifiable source code, to allow flexible adaptation to various classroom settings, published in CourseSource
The Ames Test
Version: 1.0
Introduction to the Ames Test, published as GSA Learning Resource
Bioinformatics - Investigating Sequence Similarity
Version: 4.0
This laboratory module, leads introductory biology students in the exploration of a basic set of bioinformatics concepts and tools.
Using DNA Subway to Analyze Sequence Relationships
Version: 2.0
This is a bioinformatics exercise using the DNA Subway Blue Line, a user-friendly pipeline of bioinformatics tools, to analyze a collection of mosquito DNA bar-code sequences.
C9
Murder by HIV? Undergraduate edition
Version: 1.0
Bioinformatics case study focusing on phylogenetic tree interpretation, published in the National Center for Case Study Teaching in Science
Genes and Civil Liberties
Version: 1.0
This lesson focuses on examining civil liberties issues as they relate to genetic research. Students can choose to represent an organization, real or fictional, that will report to a task force on civil liberties issues. Published in AIBS
For Sale: Iceland's Genetic History
Version: 1.0
Lesson on Iceland's genetic history, published in AIBS
To increase students' interest in their own genomes, this computer-based laboratory lesson is designed to be coupled with the opportunity for the students to be genotyped by the consumer sequencing company, 23andMe. Published in CourseSource
BSL-4: Authorized Personnel Only
Version: 1.0
National Center for Case Study Teaching in Science resource on the 2014 Ebola epidemic. This resource is also included in the NIBLSE Learning Resource Collection