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This published laboratory introduces students to the Ames test, an assay used to determine the mutagenic properties of chemical compounds, using a distinctly quantitative approach. Students must develop their own hypotheses, use proper positive and negative controls, perform their own serial dilutions, use sequencing and bioinformatics to assess their results, and finally, write up their findings in a formal laboratory report.

Citation:

Goodson-Gregg, N. and De Stasio, E. A. (2009) Reinventing the Ames Test as a Quantitative Lab That Connects Classical and Molecular Genetics. Genetics 181: 23-21. DOI: 10.1534/genetics.108.095588

• GSA PREP The Ames Test - Genetics Society of America
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Researchers should cite this work as follows:

• Nathan Goodson-Gregg, Elizabeth A. De Stasio (2021). The Ames Test. Network for Integrating Bioinformatics into Life Sciences Education, (Version 2.0). QUBES Educational Resources. doi:10.25334/P18R-F263

  BibTex | EndNote

1. Activity Length
2. Advanced
3. ames test
4. assay
5. Audience Level
6. C4. Bioinformatics tools
7. C5. Data retrieval
8. C8. Data types
9. DNA
10. Extended Project
11. genetics
12. Instructional Setting
13. Lab
14. NIBLSE
15. Recommended by NIBLSE
16. Teaching material
17. Undergraduate

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