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Colon Cancer: A Case of Genetic Bad Luck

Author(s): Anne M. Casper

Eastern Michigan University

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Case study developed for an introductory genetics class published in the National Center for Case Study Teaching in Science


In this case, developed for an introductory genetics class, students meet a woman whose family has a history of colon cancer. Students create a pedigree based on information from the case and discuss what it means to be genetically predisposed to cancer. Using bioinformatics tools from the NCBI database, students identify and examine the mutation in the woman’s APC gene that results in genetic predisposition to colon cancer.


Links to case study now housed at NSTA

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