CourseSource: Resources

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Splicing it Together: Using Primary Data to Explore RNA Splicing and Gene Expression in Large-Lecture Introductory Biology

At the heart of scientific ways of knowing is the systematic collection and analysis of data, which is then used to propose an explanation of how the world works. In this two-day module, students in a large-lecture course are immersed in a...

Courses: Biochemistry and Molecular Biology Cell Biology Genetics Introductory Biology

gene regulation transcription gene expression central dogma repressor alternative splicing mRNA processing Activator Transcription factors

Lesson

346

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74

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0

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Electron Location, Location, Location: Understanding Biological Interactions

Introductory Biology courses typically introduce the structure and function of biomolecules such as proteins and nucleic acids. To understand biomolecules fully, students require knowledge of fundamental chemistry concepts such as covalent...

Courses: Biochemistry and Molecular Biology Introductory Biology

hydrogen bonds hydrophobicity/hydrophilicity polar and non-polar covalent bonds

Essay

328

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15

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The BioTAP Professional Development Model: Expanding Empirical Research on Graduate Student Teaching Professional Development

The Biology Teaching Assistant Project (BioTAP) provides a year-long mentoring program for practitioners and researchers of Biology Graduate Teaching Assistant Teaching Professional Development (GTA TPD). The program participants, known as BioTAP...

Courses: Professional Development and Career Planning

mentoring stem community Undergraduate teaching professional development Graduate Teaching Assistant Confidence in Research Skills

Lesson

204

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12

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Gender and Classroom Participation: A Case for Quantitative Analysis

Teaching statistics to students using authentic research is one way to highlight the transferability and value of the material taught in the class. Below we describe an activity in Statistics for Biological and Health Sciences (STAT2510), an...

Courses: Science Process Skills

statistics gender population Proportion Sample Equality

Lesson

940

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58

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0

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Using Open-Source Bioinformatics and Visualization Tools to Explore the Structure and Function of SARS-CoV-2 Spike Protein

The relationship between protein structure and function is a foundational concept in undergraduate biochemistry. We find this theme is best presented with assignments that encourage exploration and analysis. Here, we share a series of four...

Courses: Biochemistry and Molecular Biology Bioinformatics Science Process Skills

bioinformatics molecular modeling COVID19 protein structure and function UCSF Chimera SARS-CoV-2 spike protein ACE2 receptor

Teaching Tools and Strategies

621

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74

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A How to Guide and Template for Designing a Puzzle Based Escape Room Game

Educational games are one active and effective way of engaging students with material while also providing additional motivation to tackle challenging concepts. A particularly popular game concept is the escape room, where students need to work in...

Courses: Biochemistry and Molecular Biology Bioinformatics Ecology Ecology Evolution Genetics Science Process Skills

Problem Solving Collaborative Work Correct Misconceptions

Lesson

515

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67

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A Classroom Intervention to Reduce Confirmation Bias

STEM students are often unable to recognize cognitive bias in their own disciplines, and simply describing cognitive bias to students has shown to be insufficient to improve critical thinking. However, habitual metacognitive techniques show...

Courses: Science Process Skills

bias process of science metacognition Confirmation Bias Cognitive Bias

Lesson

753

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125

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0

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Learning Quantitative Genetics: Investigation of Genetic Control for Cold Stress Response in Plants

Course-embedded undergraduate research experiences (CUREs) for students have been shown to increase students’ understanding of the process of science, affirm their scientific identity, and improve retention in STEM fields. Despite many CUREs...

Courses: Genetics

data analysis recombination plants quantitative genetics abiotic stress response genetic control of complex traits inheritance of complex traits

Lesson

526

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67

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1

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Teaching Advanced Concepts in Regulation of the Lac Operon With Modeling and Simulation

Success in biochemistry and other life science courses requires that students understand important biological concepts. One of these concepts is how gene regulation ensures that homeostasis is maintained in an organism. The lac operon is a...

Courses: Biochemistry and Molecular Biology

gene regulation inducible operon Prokaryotic cell Phosphoenolpyruvate transferase system (PTS)

Teaching Tools and Strategies

1235

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201

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"I Really Enjoy These Annotations:" Examining Primary Biological Literature Using Collaborative Annotation

Critically reading and evaluating claims made in the primary literature are vital skills for the future professional and personal lives of undergraduate students. However, the formal presentation of intricate content in primary research articles...

Courses: Developmental Biology Neurobiology

Stem cells Adult neurogenesis CRISPR gene editing

Lesson

2669

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91

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Meiosis Remodeled: Inclusion of New Parts to Poppit Bead Models Enhances Understanding of Meiosis

A long-standing tradition uses strings of poppit beads of different colors to model meiosis, especially to show how segments of paired homologous chromosomes are recombined. Our use of orthodontic latex bands to model cohesion of sister...

Courses: Cell Biology Genetics Introductory Biology

meiosis chiasma formation chromosome recombination

Lesson

2223

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113

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Does Organelle Shape Matter?: Exploring Patterns in Cell Shape and Structure with High-Throughput (HT) Imaging

Organelle structure has been studied and visualized for decades; however, publicly available databases that use improved high-throughput microscopy of gene-edited cell lines have recently revolutionized the amount and quality of information now...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Genetics Science Process Skills

modeling case study microscopy structure Organelles High-throughput (HT) Endoplasmic Reticulum (ER) Fluorescent microscopy Human Cell Biology

Lesson

654

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254

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Teaching the Central Dogma Using a Case Study of Genetic Variation in Cystic Fibrosis

The central dogma of biology is a foundational concept that is traditionally included in genetics curricula at all academic levels. Despite its ubiquitous presence throughout genetics education, students persistently struggle with both the...

Courses: Genetics

transcription central dogma translation sequence analysis DNA replication genetic variants

Lesson

1247

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217

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Using Bioinformatics and Molecular Visualization to Develop Student Hypotheses in a Malate Dehydrogenase Oriented CURE

Developing student creativity and ability to develop a testable hypothesis represents a significant challenge in most laboratory courses. This lesson demonstrates how students use facets of molecular evolution and bioinformatics approaches...

Courses: Biochemistry and Molecular Biology Bioinformatics Science Process Skills

bioinformatics Noncovalent Interactions Enzyme Catalysis Protein Structure/function

Teaching Tools and Strategies

1015

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A 360˚ View of COVID-19

In March 2020, institutions underwent a massive transition to distance learning as a result of the COVID-19 pandemic. With so little time to devise new materials to maximize learning in the new virtual environment, instructors devised a variety of...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Evolution Genetics Immunology Introductory Biology Microbiology Science Process Skills

genetics Immunology Biochemistry bioinformatics molecular evolution public health virus COVID19

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Splicing it Together: Using Primary Data to Explore RNA Splicing and Gene Expression in Large-Lecture Introductory Biology

Electron Location, Location, Location: Understanding Biological Interactions

The BioTAP Professional Development Model: Expanding Empirical Research on Graduate Student Teaching Professional Development

Gender and Classroom Participation: A Case for Quantitative Analysis

Using Open-Source Bioinformatics and Visualization Tools to Explore the Structure and Function of SARS-CoV-2 Spike Protein

A How to Guide and Template for Designing a Puzzle Based Escape Room Game

A Classroom Intervention to Reduce Confirmation Bias

Learning Quantitative Genetics: Investigation of Genetic Control for Cold Stress Response in Plants

Teaching Advanced Concepts in Regulation of the Lac Operon With Modeling and Simulation

"I Really Enjoy These Annotations:" Examining Primary Biological Literature Using Collaborative Annotation

Meiosis Remodeled: Inclusion of New Parts to Poppit Bead Models Enhances Understanding of Meiosis

Does Organelle Shape Matter?: Exploring Patterns in Cell Shape and Structure with High-Throughput (HT) Imaging

Teaching the Central Dogma Using a Case Study of Genetic Variation in Cystic Fibrosis

Using Bioinformatics and Molecular Visualization to Develop Student Hypotheses in a Malate Dehydrogenase Oriented CURE

A 360˚ View of COVID-19