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Single Cell Insights Into Cancer Transcriptomes: A Five-Part Single-Cell RNAseq Case Study Lesson
There is a growing need for integration of “Big Data” into undergraduate biology curricula. Transcriptomics is one venue to examine biology from an informatics perspective. RNA sequencing has largely replaced the use of microarrays for...
bioinformatics cancer transcriptomics high-throughput Data wrangling Single cell RNA sequencingq
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Design Your Own Flow Cytometry Experiment: A Four-Week Inquiry Laboratory
Due to its importance to the field, flow cytometry should be one of the hallmark methods a student learns in the lab portion of an undergraduate immunology course. Flow cytometry is a classic lab technique utilized within immunology and molecular...

Courses: ImmunologyImmunology

Immunology experimental design Flow cytometry Mice
Lesson
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A CURE for Salmonella: A Laboratory Course in Pathogen Microbiology and Genomics
Rapid advances in genomics and bioinformatics, the vast amount of data generated by next-generation sequencing, and the penetration of the ‘-omics’ into many areas of biology have created a need for students with hands-on experience...
epidemiology research bioinformatics genomics public health Antibiotic Resistant Bacteria Salmonella DNA sequencing pathogenic bacteria
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An undergraduate bioinformatics curriculum that teaches eukaryotic gene structure
Gene structure, transcription, translation, and alternative splicing are challenging concepts for many undergraduates studying biology. These topics are typically covered in a traditional lecture environment, but students often fail to master and...
bioinformatics Genome Browser genomics RNAseq splicing Computer Model Gene Structure
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Science and Society: Integrating Historical Science Materials Into an Undergraduate Biology Course
Vision and Change in Undergraduate Biology Education (American Association for the Advancement of Science, 2011) stresses the importance of fostering an understanding of the relationship between science and society. We describe a library-based...

Courses: MicrobiologyMicrobiology

infectious disease vaccination bacteria viruses antibiotics
Lesson
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27

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Follow the Sulfur: Using Yeast Mutants to Study a Metabolic Pathway
Students are frequently overwhelmed by the complexity of metabolic pathways and they think they have "learned" the pathway when they have memorized the individual reactions.  This laboratory lesson helps students to understand the...
Selection yeast Metabolism cysteine media methionine mutant Pathway sulfur
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Learning About Protein Localization: A Lesson for Analyzing Figures in a Scientific Publication
In order to function correctly, proteins must be localized to a specific subcellular location. We have designed this lesson to use data from the primary literature to teach students about the mechanisms cells use to direct proteins to the...

Courses: Cell BiologyCell Biology

colocalization immunofluorescence Protein localization signal sequences subcellular fractionation western blotting
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31

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Investigating Enzyme Structure and Function Through Model-Building and Peer Teaching in an Introductory Biology Course
A foundational knowledge of the relationship between structure and function is critical to understanding how enzymes work. The seemingly invisible nature of these molecular interactions makes it challenging for undergraduate students to...
structure-function Enzyme allosteric regulation competitive inhibition feedback inhibition noncompetitive inhibition product substrate
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Using Comics to Make Science Come Alive
Students often see science as a fragmented set of facts to be memorized, rather than concepts and processes that are relevant in their everyday lives. This is especially true for non-science majors, who represent the vast majority of all college...
role of science in society
Teaching Tools and Strategies
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Drawing flowcharts of lab protocols helps students prepare for biology labs
With the publishing of the Vision and Change report, we know it is best practice to include authentic research experiences in our undergraduate science lab classes. One big challenge in teaching so-called "wet lab" classes is figuring...
laboratory molecular biology Undergraduate protocol flowchart
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Fly Exercise: A Simple Experiment to Test the Physiological Effects of Exercise on a Model Organism
Model organisms are commonly used to study and experimentally explore biological processes in ways that are technically or ethically not possible in humans. For this reason, model organisms are an essential component of scientific research and...
exercise enzyme kinetics metabolite concentration model species physical activity
Essay
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The Impact of Diet and Antibiotics on the Gut Microbiome: Distance Education Variant
The goal of this article is to describe a variation of an active learning exercise that was previously published by the same author under a similar title. The variation describes modifications instructors can use to make the exercise suitable for...
microbiome nutrition bacterial metabolites gut bacteria host response
Teaching Tools and Strategies
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Converting a Face-to-Face Lab to Online: An Example of Process and Outcomes for a CRISPR-Based Molecular Biology Lab
The COVID-19 pandemic created a need to convert in-person laboratory courses into an online format in a short amount of time. For this reason, we converted our face-to-face molecular biology lab course to an online version in Spring 2020. The lab...
mutation transcription crispr translation
Lesson
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"Got Algae?" A Sorting Game for Introducing the Weird and Wonderful Diversity of Algae
Algae are a fascinating and diverse organismal group, with global ecological importance, a storied evolutionary history and deep connections to both contemporary and historical human societies. Yet non-experts who teach algal diversity face a lack...
phylogeny Biodiversity photosynthesis algae seaweed monophyly
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Assessing in vivo Antimicrobial Activity Through the Analysis of Galleria mellonella Kaplan-Meier Plots
Antimicrobials and their use in the treatment of bacterial infections are a fundamental lesson in all microbiology courses. Typically, cultivation-based methods are used to teach students about antimicrobial testing. A complementary approach...

Courses: MicrobiologyMicrobiology

Antimicrobial Testing Antimicrobials Invertebrate animal models