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    A new approach to course-based research using a hermit crab-hydrozoan symbiosis
    There are few feasible models for marine-focused inquiry laboratory activities, a notable shortcoming for instructors seeking to engage their students in meaningful, course-based research experiences (CUREs). We describe a multi-week CURE that...
    behaviorparasitismSymbiosismutualismcommensalism
    Lesson
    4015

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    709

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    Using Yeast to Make Scientists: A Six-Week Student-Driven Research Project for the Cell Biology Laboratory
    Traditionally-trained undergraduate students often lack an understanding of science as an active process that yields the information presented in their textbooks. One result has been a call for more research experiences built into traditional...
    yeastgrowth curvecell proliferationviability
    Lesson
    1934

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    406

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    Antibiotic Resistance Genes Detection in Environmental Samples
    Our aim is to provide an authentic research experience for undergraduate students in a variety of biology courses through collaboration between a four-year university and a community college. This lab series teaches transferable and universal...
    geneticsenvironmentmicrobiologyUndergraduateantibiotic-resistancePCRgel electrophoresisauthentic inquiry
    Lesson
    3168

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    494

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    Knowing your own: A classroom case study using the scientific method to investigate how birds learn to recognize their offspring
    Understanding the scientific method provides students with a necessary foundation for careers in science-related fields. Moreover, students can apply scientific inquiry skills in many aspects of their daily lives and decision making. Thus, the...
    scientific methodNatural Selectionbrood parasitism
    Teaching Tools and Strategies
    1778

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    295

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    "Reading groups" in an undergraduate biology course: A peer-based model to help students develop skills to evaluate primary literature
    Undergraduates who learn to evaluate primary literature demonstrate an enhanced ability to understand the process of science, weigh scientific evidence, and think critically (e.g. 6,8). Studies show that students who learn how to dissect primary...
    primary literaturecritical thinkingSelf-EfficacyDiscussionPeer-based Learning
    Lesson
    1530

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    164

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    Inexpensive Cell Migration Inquiry Lab using Zebrafish
    Cell migration is an important and interesting topic that has the potential to engage students in cell biology by its intrinsically active nature. However, most ways to investigate cell migration require expensive equipment not typically available...
    CytoskeletonCell migrationmodel organisms
    Lesson
    2955

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    562

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    Predicting and classifying effects of insertion and deletion mutations on protein coding regions
    Mutations in genes can affect the encoded proteins in multiple ways, and some of these effects are counterintuitive. As for any other knowledge, students must create their own deep understanding of the Central Dogma. Students may not develop this...
    mutationcentral dogmatranslationframeshift
    Lesson
    1588

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    455

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    Out of Your Seat and on Your Feet! An adaptable course-based research project in plant ecology for advanced students
    University capstone projects can offer science students a rich research experience that illustrates the process of doing scientific research, and can also help students better choose future academic and career pathways. While capstone projects are...
    statisticsactive learningecologyinterdisciplinaryplantscommunicating sciencegroup workfield workproces of science
    Lesson
    2762

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    665

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    Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Genetics (analyzing mutant promoters)
    Students often memorize the definition of a transcriptional promoter but fail to fully understand the critical role promoters play in gene expression.  This laboratory lesson allows students to conduct original research by characterizing...
    bacteriasynthetic biologygene regulationtranscriptionstudent researchcentral dogmacloningpromoterreporter gene/protein
    Lesson
    1046

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    365

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    Your Tax Dollars at Work: A mock grant writing experience centered on scientific process skills
    A successful scientist combines skill, creativity, and the art of persuasion to excel in his or her field of study. Critically important for the professional scientist is the ability to not only conduct research, but also to conceive a project and...
    researchexperimental designprocess of sciencePeer reviewgrant writingPecha Kuchaproposal
    Lesson
    2663

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    570

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    Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Introductory Biology (identifying new promoters)
    Students often memorize the definition of a transcriptional promoter but fail to fully understand the critical role promoters play in gene expression. This laboratory lesson allows students to conduct original research by identifying and...
    bacteriasynthetic biologygene regulationtranscriptionstudent researchcentral dogmacloningpromoterreporter gene/protein
    Lesson
    1595

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    284

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    Authentic Ecological Inquiries Using BearCam Archives
    Learning through authentic scientific inquiries is essential for understanding the nature and process of science and for developing critical thinking and communication skills. It is logistically challenging, however, to offer experiences of...
    behaviorinterspecific interactionsPeer reviewauthentic inquiryintra-specific interactions
    Lesson
    1977

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    451

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    Air Quality Data Mining: Mining the US EPA AirData website for student-led evaluation of air quality issues
    Air pollution directly affects human health endpoints including growth, respiratory processes, cardiovascular health, fertility, pregnancy outcomes, and cancer. Therefore, the distribution of air pollution is a topic that is relevant to all, and...
    data miningenvironmental justiceair qualityairpollutionspatial reasoning
    Teaching Tools and Strategies
    2689

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    438

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    A Strategy for Teaching Undergraduates to Write Effective Scientific Results Sections
    Most undergraduate instructors would agree that learning to write about data in the style of a scientific research paper is a worthy goal for their students.  However, many hesitate to tackle the challenge of teaching scientific writing in...
    data analysisprimary literaturescientific writingcommunicating science
    Lesson
    2896

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    637

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    A Hands-on Introduction to Hidden Markov Models
    In this Lesson, we describe a classroom activity that demonstrates how a Hidden Markov Model (HMM) is applied to predict a eukaryotic gene, focusing on predicting one exon-intron boundary. This HMM lesson is part of the BIOL/CS 370...
    transcriptionexonintronsplicing
    Lesson
    1300

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    135

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    Infectious Chocolate Joy with a Side of Poissonian Statistics: An activity connecting life science students with subtle physics concepts
    Introductory physics courses are required for many programs in the life sciences, yet traditional curricula fail to help students meaningfully connect physical concepts with biological systems.  In this lesson, we describe an activity taught...
    quantitative biologyHIVmultiplicity of infectionPoisson DistributionPhysics for biologists
    Lesson
    1796

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    545

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    Using Undergraduate Molecular Biology Labs to Discover Targets of miRNAs in Humans
    Incorporating authentic research experiences into undergraduate labs, while shown to be particularly effective at engaging and retaining students in STEM majors, can be difficult to accomplish within the constraints of resource availability or...
    gene regulationmicroRNAsgene expression
    Lesson
    2125

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    266

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    You and Your Oral Microflora: Introducing non-biology majors to their “forgotten organ”
    With limited time available for laboratory activities, introductory science courses for non-science majors typically use the laboratory period to reinforce material that was previously presented during lecture. This practice was true of a human...
    bacteriamicrobiomeBLASTmicrobesDNA replicationPolymerase chain reaction (PCR)
    Lesson
    1189

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    486

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    Using Pathway Maps to Link Concepts, Peer Review, Primary Literature Searches and Data Assessment in Large Enrollment Classes: An example from teaching ecosystem ecology
    As with many other complex topics, teaching ecosystem ecology can be particularly difficult in terms of helping students understand the relationships between the various component parts. We addressed this challenge in a general ecology course by...
    energyecosystemNutrientsPathway
    Lesson
    2476

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    603

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    The Case of the Missing Strawberries: RFLP analysis
    While solving the fictional mystery of the missing strawberries, students are engaged in a guided-inquiry lesson featuring small-group and class discussions, hands-on activities, and laboratory exercises related to molecular genotyping by...
    process of scienceDNAforensicsgel electrophoresisMolecular genotypingRestriction endonucleaseRestriction enzymeRestriction fragment length polymorphismRFLP