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    1402

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    385

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    Mice, Acorns, and Lyme Disease: a Case Study to Teach the Ecology of Emerging Infectious Diseases.
    Ebola, Zika, the recall of contaminated lettuce - these are just a few recent outbreaks making headlines. Students should be able to connect what they learn in their biology courses to explain these events happening around them. Unfortunately,...

    Courses: MicrobiologyMicrobiology

    epidemiologyEcological changeInfectious disease ecologyReservoirsTransmission cycle
    Science Behind the Lesson
    1483

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    202

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    0

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    The Science Behind the ACTN3 Polymorphism
    A common polymorphism in the alpha-actinin-3 (ACTN3) gene results in the lack of ACTN3 protein expression in fast twitch muscle fibers in ~16% of the human population (1). This genetic change has been linked with muscle performance in humans (2)...

    Courses: Anatomy-PhysiologyAnatomy-Physiology GeneticsGenetics

    protein structure and functionhuman genetic variationskeletal muscle physiology
    Lesson
    1763

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    226

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    0

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    Using a Sequential Interpretation of Data in Envelopes (SIDE) approach to identify a mystery TRP channel
    This lesson sought to engage students in data interpretation and to encourage critical thinking about neurophysiology in the context of temperature sensation. A family of receptors called Transient Receptor Potential (TRP) channels are activated...

    Courses: Anatomy-PhysiologyAnatomy-Physiology Cell BiologyCell Biology NeurobiologyNeurobiology

    Cell communicationChannel specificity and activationLimitations of tools of Cell BiologyNeuronal Signaling
    Lesson
    4196

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    667

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    0

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    Design Your Own Flow Cytometry Experiment: A Four-Week Inquiry Laboratory
    Due to its importance to the field, flow cytometry should be one of the hallmark methods a student learns in the lab portion of an undergraduate immunology course. Flow cytometry is a classic lab technique utilized within immunology and molecular...

    Courses: ImmunologyImmunology

    Immunologyexperimental designFlow cytometryMice
    Lesson
    1272

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    290

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    0

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    Using a Primary Cell Culture Model to Study the Neural Extracellular Matrix
    The extracellular matrix (ECM) provides structural support to cells, but also has key roles in mediating cell adhesion, cell signaling, and differentiation. While this topic is discussed in the lecture setting, it is not heavily studied in...

    Courses: Cell BiologyCell Biology NeurobiologyNeurobiology

    Neural extracellular matrixPerineuronal netPrimary neuronal culture
    Teaching Tools and Strategies
    1736

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    326

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    0

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    SCIENCE/Fiction: Modular Template for Class Design
    We present a modular scaffold for designing an introductory seminar using speculative fiction and science papers to welcome university undergraduates to the biology major. A list of twelve possible topics is included, such as Memory, Parasites,...

    Courses: Anatomy-PhysiologyAnatomy-Physiology Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Cell BiologyCell Biology EvolutionEvolution GeneticsGenetics Introductory BiologyIntroductory Biology NeurobiologyNeurobiology

    geneticscell biologyneurosciencesystems biologyScience Fiction
    Essay
    1415

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    135

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    0

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    Going Remote: An Online Adaptation to Using a Primary Cell Culture Model to Study the Neural Extracellular Matrix
    In light of the COVID-19 pandemic, instructors have modified materials to transition to a remote learning platform. The challenge for science instructors has been to design lab exercises that incorporate both active and experiential learning. In...

    Courses: Cell BiologyCell Biology NeurobiologyNeurobiology

    remote learningExtracellular matrixNeural extracellular matrixPerineuronal net
    Lesson
    2045

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    890

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    0

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    Exploration of the Human Genome by Investigation of Personalized SNPs
    Students often shy away from tedious bioinformatics approaches to exploring their genomes. However, in our expanding digital world these skills are some of the most relevant and valuable. To increase students' interest in their own genomes, I...

    Courses: BioinformaticsBioinformatics GeneticsGenetics Science Process SkillsScience Process Skills

    UCSC genome browsersingle nucleotide polymorphismGenome wide association studiesGenomic organization
    Science Behind the Lesson
    2009

    views

    294

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    0

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    The Science Behind Parthenogenesis: Interesting things happen when meiosis goes “wrong”
    Parthenogenetic reproduction is a fascinating, complex topic.  This article accompanies “Why Meiosis Matters: The case of the fatherless snake.” It summarizes the basic information an introductory biology or genetics instructor...

    Courses: Cell BiologyCell Biology GeneticsGenetics Introductory BiologyIntroductory Biology

    meiosismitosissex determinationAsexual reproductionParthenogenesis
    Lesson
    4806

    views

    737

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    0

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    A simple way for students to visualize cellular respiration: adapting the board game MousetrapTM to model complexity
    Lecture-based introductory biology courses are typically content-heavy as instructors strive to provide students with foundational knowledge in a broad range of topics.  One topic traditionally covered is cellular respiration, the series of...

    Courses: Introductory BiologyIntroductory Biology

    ATPGlycolysisCellular RespirationElectron Transport ChainKrebs Cycle
    Lesson
    2688

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    496

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    0

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    Harnessing the Power of the Immune System: Influenza Vaccines
    Because most people have been infected by and/or immunized against influenza, students should know how the immune system responds to the infection and how vaccines protect against disease. Vaccines have played an instrumental role in disease...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology ImmunologyImmunology Science Process SkillsScience Process Skills

    VaccinesInfluenzaImmunizationVaccine efficacy
    Lesson
    2802

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    703

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    Teaching Biodiversity with Museum Specimens in an Inquiry-Based Lab
    In response to the growth of biology datasets and broad efforts to digitize data, an increasingly important skill for science students is the management and analysis of large datasets. We designed an inquiry-based lab module to introduce students...

    Courses: EcologyEcology EvolutionEvolution Introductory BiologyIntroductory Biology Science Process SkillsScience Process Skills

    data analysisnatural historyphylogenyBiodiversitymammalsAllen's RuleBergmann's Ruleecogeographymuseum research
    Essay
    755

    views

    128

    downloads

    1

    comments

    Helping Students to Overcome STUMPS: Scientific terms undermined by meanings peripheral to science
    Many terms and phrases that are ubiquitous in everyday use have very different meanings in science. As a result, biology students often hold prior conceptions that are difficult to change. In this essay, I refer to such problematic terms as...

    Courses: Introductory BiologyIntroductory Biology

    Evolutionfitnessprocess of sciencetree of lifemetacognitionlanguagemisconceptionsTerminologyTheory
    Lesson
    1651

    views

    244

    downloads

    0

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    Make It Stick: Teaching Gene Targeting with Ribbons and Fasteners
    Manipulating gene expression is a commonly used tool to study the effect of a single gene or the hierarchy of gene networks in many different biological disciplines. When working with mice, the most commonly used techniques to manipulate genes...

    Courses: Developmental BiologyDevelopmental Biology GeneticsGenetics

    mathematical modelhomologous recombinationCre/loxgene targeting
    Lesson
    2000

    views

    176

    downloads

    0

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    Fly Exercise: A Simple Experiment to Test the Physiological Effects of Exercise on a Model Organism
    Model organisms are commonly used to study and experimentally explore biological processes in ways that are technically or ethically not possible in humans. For this reason, model organisms are an essential component of scientific research and...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Introductory BiologyIntroductory Biology Science Process SkillsScience Process Skills

    exerciseenzyme kineticsmetabolite concentrationmodel speciesphysical activity
    Science Behind the Lesson
    656

    views

    58

    downloads

    0

    comments

    X-ploring Fragile X: The Science Behind the Syndrome
    Fragile X Syndrome is an X-linked genetic disorder resulting from the impairment of transcription of the FMR1 gene, producing less to no FMRP protein. FMRP is a translational inhibitor that plays a key role in neurological development. Recent...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology GeneticsGenetics Introductory BiologyIntroductory Biology

    epigeneticsgene regulationtranscriptioncentral dogmatranslationFragile X syndromeSphingosine Metabolism
    Lesson
    1499

    views

    528

    downloads

    0

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    Building a Model of Tumorigenesis: A small group activity for a cancer biology/cell biology course
    The multistep nature of tumorigenesis is a foundational concept in the context of Cancer Biology. Many students do not appreciate the complex nature of cancer development nor do they understand how scientists are able to unravel the molecular...

    Courses: Cell BiologyCell Biology GeneticsGenetics Science Process SkillsScience Process Skills

    pathwayscancerMolecular AlterationsRetrospective dataTumorigenesis
    Essay
    1221

    views

    178

    downloads

    0

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    Squirreling from Afar: Adapting Squirrel-Net Modules for Remote Teaching and Learning
    The shift from face-to-face instruction to remote teaching and learning has proven to be a challenging endeavor for many reasons, including lack of time, resources, and inspiration. Lab courses, the "hands-on" portion of many curricula,...

    Courses: EcologyEcology Introductory BiologyIntroductory Biology Science Process SkillsScience Process Skills

    online learningbehavioral ecologyCUREsRemote teachingfield ecologySquirrelSquirrel-Net
    Lesson
    2091

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    288

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    0

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    Assessing in vivo Antimicrobial Activity Through the Analysis of Galleria mellonella Kaplan-Meier Plots
    Antimicrobials and their use in the treatment of bacterial infections are a fundamental lesson in all microbiology courses. Typically, cultivation-based methods are used to teach students about antimicrobial testing. A complementary approach...

    Courses: MicrobiologyMicrobiology

    Antimicrobial TestingAntimicrobialsInvertebrate animal models
    Lesson
    3619

    views

    954

    downloads

    0

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    Life Is Just a Game: An Active Learning Activity to Teach Life History Evolution
    A novel activity was designed to introduce students to the concepts of natural selection and life history using an active-learning, constructivist format. It consisted of two parts: 1) a brief introduction to the basic mechanism of natural...

    Courses: EcologyEcology EvolutionEvolution

    Evolutionlife historytrade-offsdiversityNatural Selection