CourseSource: Resources

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Moths and Frogs and E. coli, Oh My!: Agent-based Modeling of Evolutionary Systems

In evolution classrooms, introducing and reinforcing the idea of genetic drift and random selection can be challenging, as can be reinforcing appropriate mental models of evolution. Agent-based models offer students the opportunity to conduct a...

Courses: Bioinformatics Ecology Ecology Evolution Science Process Skills

modelingEvolutionecologyagent-based modelingGenetic Driftenvironmental scienceNatural Selectioncompetitive coevolutionsimulation modelingevolutionary reasoning

Lesson

3370

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279

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Application of a Bacterial Experimental Evolution System to Visualize and Teach Evolution in Action: A Course-Based Undergraduate Research Experience

Concepts of evolution are typically taught through examples of extremely long timescales, which do not always resonate broadly. Here, we describe a course-based undergraduate research experience tailored for junior and senior undergraduate biology...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Evolution Genetics Microbiology

EvolutionmutationcompetitionNatural Selectionregulationstructure and functionreproductive fitnessgenotype to phenotypehomologs

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2170

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668

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1

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Sequence Similarity: An inquiry based and "under the hood" approach for incorporating molecular sequence alignment in introductory undergraduate biology courses

Introductory bioinformatics exercises often walk students through the use of computational tools, but often provide little understanding of what a computational tool does "under the hood." A solid understanding of how a bioinformatics...

Courses: Biochemistry and Molecular Biology Bioinformatics Introductory Biology

BLASTmultiple sequence alignmentsequence similarityphylogramZika virusAlgorithmScoring Matrix

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4215

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628

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Using Bioinformatics and Molecular Visualization to Develop Student Hypotheses in a Malate Dehydrogenase Oriented CURE

Developing student creativity and ability to develop a testable hypothesis represents a significant challenge in most laboratory courses. This lesson demonstrates how students use facets of molecular evolution and bioinformatics approaches...

Courses: Biochemistry and Molecular Biology Bioinformatics Science Process Skills

bioinformaticsNoncovalent InteractionsEnzyme CatalysisProtein Structure/function

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2723

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435

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An Introduction to Eukaryotic Genome Analysis in Non-model Species for Undergraduates: A tutorial from the Genome Consortium for Active Teaching

Advances in Next Generation Sequencing (NGS) technology have led to development of many research methods for analyzing genomic data. Students studying biology at the undergraduate level must hone their skills at genomic analysis to participate in...

Courses: Bioinformatics Genetics Science Process Skills

Speciationgenome evolutiongenetic variation

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3718

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679

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A Hands-on Introduction to Hidden Markov Models

In this Lesson, we describe a classroom activity that demonstrates how a Hidden Markov Model (HMM) is applied to predict a eukaryotic gene, focusing on predicting one exon-intron boundary. This HMM lesson is part of the BIOL/CS 370...

Courses: Bioinformatics Genetics Science Process Skills

transcriptionexonintronsplicing

Lesson

6481

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4120

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CURE-all: Large Scale Implementation of Authentic DNA Barcoding Research into First-Year Biology Curriculum

Growing calls in science education reform have emphasized wide-scale engagement of first-year undergraduate students in authentic research experiences; however, large course enrollments, inadequate student experience, limited resources and...

Courses: Biochemistry and Molecular Biology Bioinformatics Ecology Ecology Evolution Genetics Introductory Biology Science Process Skills

phylogeneticsbioinformaticsBiodiversityprocess of sciencetaxonomyPCRDNADNA sequencegel electrophoresis

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2117

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548

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Using computational molecular modeling software to demonstrate how DNA mutations cause phenotypes

Students require a deep understanding of the central dogma before they can understand complex topics such as evolution and biochemical disorders. However, getting undergraduate biology students to apply higher-order thinking skills to the central...

Courses: Bioinformatics Genetics Science Process Skills

Protein Structurecomputational modelingcentral dogmaplant leaf structurePhenotype/Genotype

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1491

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161

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0

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Infectious Chocolate Joy with a Side of Poissonian Statistics: An activity connecting life science students with subtle physics concepts

Introductory physics courses are required for many programs in the life sciences, yet traditional curricula fail to help students meaningfully connect physical concepts with biological systems. In this lesson, we describe an activity taught...

Courses: Bioinformatics Microbiology Science Process Skills

quantitative biologyHIVmultiplicity of infectionPoisson DistributionPhysics for biologists

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6565

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1124

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Mapping a Mutation to its Gene: The "Fly Lab" as a Modern Research Experience

Although genetics is an invaluable part of the undergraduate biology curriculum, it can be intimidating to students as well as instructors: Students must reduce their reliance on memorization and dive deep into quantitative analysis, and...

Courses: Biochemistry and Molecular Biology Bioinformatics Genetics Science Process Skills

geneticsbioinformaticsdrosophilachi-square analysiscomplementation mappingmode of inheritancethree-point mapping

Lesson

1960

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281

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0

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A CURE-based approach to teaching genomics using mitochondrial genomes

There is an abundance (currently over 1016 DNA bases) of publicly available genetic sequence data and a dearth of trained genomicists to process and interpret it, necessitating more trained bioinformaticians with biological expertise. For...

Courses: Bioinformatics Genetics

proteinsMitochondrial GenomesNuclear GenomesrRNAtRNA

Lesson

3355

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618

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0

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Predicting and classifying effects of insertion and deletion mutations on protein coding regions

Mutations in genes can affect the encoded proteins in multiple ways, and some of these effects are counterintuitive. As for any other knowledge, students must create their own deep understanding of the Central Dogma. Students may not develop this...

Courses: Bioinformatics Genetics Science Process Skills

mutationcentral dogmatranslationframeshift

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1579

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301

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Using QIIME to Interpret Environmental Microbial Communities in an Upper Level Metagenomics Course

Metagenomics is rapidly evolving due to advances in sequencing technologies and bioinformatics, but without proper training to interpret these datasets, student understanding remains limited. Aimed at undergraduate juniors and seniors and graduate...

Courses: Biochemistry and Molecular Biology Bioinformatics Ecology Ecology Microbiology Science Process Skills

microbiome

Teaching Tools and Strategies

994

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202

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Making toast: Using analogies to explore concepts in bioinformatics

Contemporary biology is moving towards heavy reliance on computational methods to manage, find patterns, and derive meaning from large-scale data, such as genomic sequences. Biology teachers are increasingly compelled to prepare students with...

Courses: Bioinformatics

bioinformaticsworkflowgenome

Lesson

2017

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574

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0

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Using Undergraduate Molecular Biology Labs to Discover Targets of miRNAs in Humans

Incorporating authentic research experiences into undergraduate labs, while shown to be particularly effective at engaging and retaining students in STEM majors, can be difficult to accomplish within the constraints of resource availability or...

Courses: Bioinformatics Genetics Science Process Skills

gene regulationmicroRNAsgene expression

Lesson

3384

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1181

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0

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CRISPR/Cas9 in yeast: a multi-week laboratory exercise for undergraduate students

Providing undergraduate life-science students with a course-based research experience that utilizes cutting-edge technology, is tractable for students, and is manageable as an instructor is a challenge. Here, I describe a multi-week lesson plan...

Courses: Biochemistry and Molecular Biology Bioinformatics Genetics Microbiology Science Process Skills

bioinformaticsPCRphenotypingCRISPR/Cas9gene editingcloningGenotypingRestriction enzyme

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1746

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432

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0

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How to Find a Gene: Retrieving Information From Gene Databases

A strong understanding of distinct gene components and the ability to retrieve relevant information from gene databases are necessary to answer a diverse set of biological questions. However, often there is a considerable gap between...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Genetics Introductory Biology

NCBItranscriptiontranslationGene StructureGene databasesEnsembl

Teaching Tools and Strategies

3645

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1722

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A 360˚ View of COVID-19

In March 2020, institutions underwent a massive transition to distance learning as a result of the COVID-19 pandemic. With so little time to devise new materials to maximize learning in the new virtual environment, instructors devised a variety of...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Evolution Genetics Immunology Introductory Biology Microbiology Science Process Skills

geneticsImmunologyBiochemistrybioinformaticsmolecular evolutionpublic healthvirusCOVID19

Essay

2226

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Structuring Courses for Equity

As instructors, we continually look for new ways to create equitable learning environments and support learning for all students in our courses. Recently, we have explored ways that we can increase structure to better support students. We have...

Courses: Anatomy-Physiology Bioinformatics Cell Biology Developmental Biology Ecology Ecology Genetics Introductory Biology Microbiology Neurobiology Plant Biology Science Process Skills

Equitymetacognitioninclusivitycourse structure

Lesson

5054

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914

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0

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Tackling "Big Data" with Biology Undergrads: A Simple RNA-seq Data Analysis Tutorial Using Galaxy

Analyzing high-throughput DNA sequence data is a fundamental skill in modern biology. However, real and perceived barriers such as massive file sizes, substantial computational requirements, and lack of instructor background knowledge can...

Courses: Biochemistry and Molecular Biology Bioinformatics

bioinformaticsDNA sequenceRNAseqgene expression

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Moths and Frogs and E. coli, Oh My!: Agent-based Modeling of Evolutionary Systems

Application of a Bacterial Experimental Evolution System to Visualize and Teach Evolution in Action: A Course-Based Undergraduate Research Experience

Sequence Similarity: An inquiry based and "under the hood" approach for incorporating molecular sequence alignment in introductory undergraduate biology courses

Using Bioinformatics and Molecular Visualization to Develop Student Hypotheses in a Malate Dehydrogenase Oriented CURE

An Introduction to Eukaryotic Genome Analysis in Non-model Species for Undergraduates: A tutorial from the Genome Consortium for Active Teaching

A Hands-on Introduction to Hidden Markov Models

CURE-all: Large Scale Implementation of Authentic DNA Barcoding Research into First-Year Biology Curriculum

Using computational molecular modeling software to demonstrate how DNA mutations cause phenotypes

Infectious Chocolate Joy with a Side of Poissonian Statistics: An activity connecting life science students with subtle physics concepts

Mapping a Mutation to its Gene: The "Fly Lab" as a Modern Research Experience

A CURE-based approach to teaching genomics using mitochondrial genomes

Predicting and classifying effects of insertion and deletion mutations on protein coding regions

Using QIIME to Interpret Environmental Microbial Communities in an Upper Level Metagenomics Course

Making toast: Using analogies to explore concepts in bioinformatics

Using Undergraduate Molecular Biology Labs to Discover Targets of miRNAs in Humans

CRISPR/Cas9 in yeast: a multi-week laboratory exercise for undergraduate students

How to Find a Gene: Retrieving Information From Gene Databases

A 360˚ View of COVID-19

Structuring Courses for Equity

Tackling "Big Data" with Biology Undergrads: A Simple RNA-seq Data Analysis Tutorial Using Galaxy

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