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    Teaching the Central Dogma Using a Case Study of Genetic Variation in Cystic Fibrosis
    The central dogma of biology is a foundational concept that is traditionally included in genetics curricula at all academic levels. Despite its ubiquitous presence throughout genetics education, students persistently struggle with both the...

    Courses: GeneticsGenetics

    transcriptioncentral dogmatranslationsequence analysisDNA replicationgenetic variants
    Lesson
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    296

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    Learning Quantitative Genetics: Investigation of Genetic Control for Cold Stress Response in Plants
    Course-embedded undergraduate research experiences (CUREs) for students have been shown to increase students’ understanding of the process of science, affirm their scientific identity, and improve retention in STEM fields. Despite many CUREs...

    Courses: GeneticsGenetics

    data analysisrecombinationplantsquantitative geneticsabiotic stress responsegenetic control of complex traitsinheritance of complex traits
    Lesson
    1978

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    873

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    Exploration of the Human Genome by Investigation of Personalized SNPs
    Students often shy away from tedious bioinformatics approaches to exploring their genomes. However, in our expanding digital world these skills are some of the most relevant and valuable. To increase students' interest in their own genomes, I...

    Courses: BioinformaticsBioinformatics GeneticsGenetics Science Process SkillsScience Process Skills

    UCSC genome browsersingle nucleotide polymorphismGenome wide association studiesGenomic organization
    Science Behind the Lesson
    1920

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    289

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    The Science Behind Parthenogenesis: Interesting things happen when meiosis goes “wrong”
    Parthenogenetic reproduction is a fascinating, complex topic.  This article accompanies “Why Meiosis Matters: The case of the fatherless snake.” It summarizes the basic information an introductory biology or genetics instructor...

    Courses: Cell BiologyCell Biology GeneticsGenetics Introductory BiologyIntroductory Biology

    meiosismitosissex determinationAsexual reproductionParthenogenesis
    Lesson
    1320

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    373

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    Where Does Elsie's Hair Color Come From? A "De-Simplified" Pedigree Lesson
    Pedigree analysis is part of most Genetics curricula, but the examples traditionally used in genetics courses present phenotypes as if they were entirely and inexorably defined by genotype. This does not reflect the current state of understanding...

    Courses: GeneticsGenetics Introductory BiologyIntroductory Biology

    pedigreeMultifactorialphenotypic variationpenetranceexpressivityquantitative variation
    Lesson
    1803

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    334

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    Engaging Students in Pharmacogenetics: Patient Case Studies Using the PharmGKB Website
    Cytochrome P450 (CYP) enzymes are important regulators of drug efficacy and toxicity. Genetic variation in CYP isoforms can impact how well patients respond to medications or experience unwanted toxicities. PharmGKB is an online pharmacogenomics...

    Courses: GeneticsGenetics ToxicologyToxicology

    toxicologyPharmacologydrug metabolismpharmacodynamicspharmacogenetics
    Lesson
    3559

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    981

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    A Quick and Simple Natural Selection Role Play
    Teaching evolution remains a challenging task in biology education. Students enter the classroom with stubborn misconceptions and many traditional examples of the process of evolution may not resonate with students. This short role play activity...

    Courses: EcologyEcology EvolutionEvolution GeneticsGenetics Plant BiologyPlant Biology

    EvolutionfitnessNatural Selectionheritability
    Lesson
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    1784

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    Teaching Genetic Linkage and Recombination through Mapping with Molecular Markers
    Most introductory genetics courses cover genetic linkage, a core concept in the CourseSource genetics learning outcome framework. Although it is a classical genetics topic, genetic linkage remains an important concept to understand in order to...

    Courses: GeneticsGenetics Plant BiologyPlant Biology Science Process SkillsScience Process Skills

    meiosisphenotypegel electrophoresismicrosatellitesBanding PatternGenetic linkageInheritanceMolecular MarkersPhysical Linkage
    Science Behind the Lesson
    1401

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    196

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    The Science Behind the ACTN3 Polymorphism
    A common polymorphism in the alpha-actinin-3 (ACTN3) gene results in the lack of ACTN3 protein expression in fast twitch muscle fibers in ~16% of the human population (1). This genetic change has been linked with muscle performance in humans (2)...

    Courses: Anatomy-PhysiologyAnatomy-Physiology GeneticsGenetics

    protein structure and functionhuman genetic variationskeletal muscle physiology
    Lesson
    2958

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    395

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    Honoring the Complexity of Genetics: Exploring the Role of Genes and the Environment Using Real World Examples
    Historically, undergraduate genetics courses have disproportionately focused on the impact of genes on phenotypes, rather than multifactorial concepts which consider how a combination of genes, the environment, and gene-by-environment interactions...

    Courses: EvolutionEvolution GeneticsGenetics Introductory BiologyIntroductory Biology

    genesenvironmentMendelQuantitative traitsMultifactorialGene by environment interactions
    Lesson
    3348

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    262

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    Garden Variety Mutations: Using Primary Data to Understand the Central Dogma in Large-Lecture Introductory Biology
    The ability to interpret and create an argument from data is a crucial skill for budding scientists, yet one that is seldom practiced in introductory courses. During this argumentation module, students in a large lecture class will work in groups...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology GeneticsGenetics Introductory BiologyIntroductory Biology

    mutationtranscriptiongene expressioncentral dogmatranslationgel electrophoresisGenotype/Phenotype
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    66

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    Using Raw Sequence Data to Analyze Tumor Suppressor Mutations
    Learning to identify DNA sequence variants from raw sequencing data (electropherograms) is a basic molecular biology skill with applications to basic research and clinical practice. Yet learning to map DNA sequence variants to functional regions...

    Courses: BioinformaticsBioinformatics GeneticsGenetics

    bioinformaticsmutationDNAgenomic visualizationparts of a geneclinical consequencesraw data
    Lesson
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    333

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    A Muscular Dystrophy Case Study Illustrating the Phenotypic Effects of Mutation
    Mutations in genes can lead to a variety of phenotypes, including various human diseases. Students often understand that a particular mutation in a single gene causes a disease phenotype, but it is more challenging to illustrate complex genetic...

    Courses: Developmental BiologyDevelopmental Biology GeneticsGenetics

    mutationProtein Structureethicscentral dogmahuman disease
    Lesson
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    509

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    Building a Model of Tumorigenesis: A small group activity for a cancer biology/cell biology course
    The multistep nature of tumorigenesis is a foundational concept in the context of Cancer Biology. Many students do not appreciate the complex nature of cancer development nor do they understand how scientists are able to unravel the molecular...

    Courses: Cell BiologyCell Biology GeneticsGenetics Science Process SkillsScience Process Skills

    pathwayscancerMolecular AlterationsRetrospective dataTumorigenesis
    Lesson
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    The Great Petunia Carnage of 2017: A Clicker Case Study Using Petunias to Describe the Effect of Genetic Modification on the Biochemistry of Flower Color and Phenotype in Plants
    In this single class period case study, students examine the difference between genotype and phenotype by studying the mechanisms by which commercially available petunias have been bred to have different phenotypes (flower colors). Students review...

    Courses: GeneticsGenetics Introductory BiologyIntroductory Biology Plant BiologyPlant Biology

    case studyGenetic ModificationsBiochemistry of Flower ColorGMO regulationsGenotype-Phenotype Connections
    Lesson
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    1229

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    My Dog IS My Homework: Exploring Canine Genetics to Understand Genotype-Phenotype Relationships
    To facilitate understanding of the fundamental genetic concept of the genotype-phenotype relationship in our introductory biology students, we designed an engaging multi-week series of related lessons about canine genetics in which students...

    Courses: BioinformaticsBioinformatics GeneticsGenetics Introductory BiologyIntroductory Biology Science Process SkillsScience Process Skills

    gel electrophoresissequence analysiscanine geneticsdeoxyribonucleic acid (DNA)dog coat morphologygenotype and phenotypemutationsPolymerase chain reaction (PCR)single nucleotide polymorphism (SNP)
    Lesson
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    1074

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    Mapping a Mutation to its Gene: The "Fly Lab" as a Modern Research Experience
    Although genetics is an invaluable part of the undergraduate biology curriculum, it can be intimidating to students as well as instructors: Students must reduce their reliance on memorization and dive deep into quantitative analysis, and...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology BioinformaticsBioinformatics GeneticsGenetics Science Process SkillsScience Process Skills

    geneticsbioinformaticsdrosophilachi-square analysiscomplementation mappingmode of inheritancethree-point mapping
    Lesson
    3395

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    713

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    Homologous chromosomes? Exploring human sex chromosomes, sex determination and sex reversal using bioinformatics approaches
    Constructing a robust understanding of homologous chromosomes, sex chromosomes, and the particulate nature of genes is a notoriously difficult task for undergraduate biology students. In this lesson, students expand their knowledge of human...

    Courses: BioinformaticsBioinformatics GeneticsGenetics Introductory BiologyIntroductory Biology Science Process SkillsScience Process Skills

    bioinformaticsautosomehomologous chromosomeshomologous recombinationsex chromosomesex determinationsex reversal mutations
    Lesson
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    160

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    A Rapid Genetic Screen Using Wisconsin Fast Plants®: A Hands-On Approach to Inheritance of de novo Mutations
    Some concepts in genetics, such as genetic screens, are complex for students to visualize in a classroom and can be cumbersome to undertake in the laboratory. Typically, very large populations are needed, which can be addressed by using...

    Courses: GeneticsGenetics Plant BiologyPlant Biology

    mutationInheritancegermlinesomaplant lifecycle
    Lesson
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    Student-Generated Analogies for Learning about Information Flow
    Using analogies is a standard practice for both teaching and communicating ideas in science. Here we upend the traditional lesson, where the instructor provides a fully constructed analogy and explains it, by having the students develop a complex...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Cell BiologyCell Biology GeneticsGenetics Introductory BiologyIntroductory Biology

    critical thinkingcentral dogmaanalogical reasoning