CourseSource: Resources

Teaching Tools and Strategies

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A 360˚ View of COVID-19

In March 2020, institutions underwent a massive transition to distance learning as a result of the COVID-19 pandemic. With so little time to devise new materials to maximize learning in the new virtual environment, instructors devised a variety of...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Evolution Genetics Immunology Introductory Biology Microbiology Science Process Skills

geneticsImmunologyBiochemistrybioinformaticsmolecular evolutionpublic healthvirusCOVID19

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2023

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889

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Exploration of the Human Genome by Investigation of Personalized SNPs

Students often shy away from tedious bioinformatics approaches to exploring their genomes. However, in our expanding digital world these skills are some of the most relevant and valuable. To increase students' interest in their own genomes, I...

Courses: Bioinformatics Genetics Science Process Skills

UCSC genome browsersingle nucleotide polymorphismGenome wide association studiesGenomic organization

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2784

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677

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The Case of the Missing Strawberries: RFLP analysis

While solving the fictional mystery of the missing strawberries, students are engaged in a guided-inquiry lesson featuring small-group and class discussions, hands-on activities, and laboratory exercises related to molecular genotyping by...

Courses: Genetics Science Process Skills

process of scienceDNAforensicsgel electrophoresisMolecular genotypingRestriction endonucleaseRestriction enzymeRestriction fragment length polymorphismRFLP

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1843

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Teaching Genetic Linkage and Recombination through Mapping with Molecular Markers

Most introductory genetics courses cover genetic linkage, a core concept in the CourseSource genetics learning outcome framework. Although it is a classical genetics topic, genetic linkage remains an important concept to understand in order to...

Courses: Genetics Plant Biology Science Process Skills

meiosisphenotypegel electrophoresismicrosatellitesBanding PatternGenetic linkageInheritanceMolecular MarkersPhysical Linkage

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3056

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452

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Moths and Frogs and E. coli, Oh My!: Agent-based Modeling of Evolutionary Systems

In evolution classrooms, introducing and reinforcing the idea of genetic drift and random selection can be challenging, as can be reinforcing appropriate mental models of evolution. Agent-based models offer students the opportunity to conduct a...

Courses: Bioinformatics Ecology Ecology Evolution Science Process Skills

modelingEvolutionecologyagent-based modelingGenetic Driftenvironmental scienceNatural Selectioncompetitive coevolutionsimulation modelingevolutionary reasoning

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Does it pose a threat? Investigating the impact of Bt corn on monarch butterflies

Aspiring scientists know that a hallmark of science is that experiments are repeatable and testable. However, students do not often get opportunities to explore the replicability of science. Using a current “hot topic” of...

Courses: Ecology Ecology Genetics Introductory Biology Science Process Skills

ecologyCommunity EcologyBt cornGenetic modificationMonarch butterflies

Teaching Tools and Strategies

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323

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"Reading groups" in an undergraduate biology course: A peer-based model to help students develop skills to evaluate primary literature

Undergraduates who learn to evaluate primary literature demonstrate an enhanced ability to understand the process of science, weigh scientific evidence, and think critically (e.g. 6,8). Studies show that students who learn how to dissect primary...

Courses: Biochemistry and Molecular Biology Science Process Skills

primary literaturecritical thinkingSelf-EfficacyDiscussionPeer-based Learning

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521

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Building a Model of Tumorigenesis: A small group activity for a cancer biology/cell biology course

The multistep nature of tumorigenesis is a foundational concept in the context of Cancer Biology. Many students do not appreciate the complex nature of cancer development nor do they understand how scientists are able to unravel the molecular...

Courses: Cell Biology Genetics Science Process Skills

pathwayscancerMolecular AlterationsRetrospective dataTumorigenesis

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1038

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164

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0

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Outside the Norm: Using Public Ecology Database Information to Teach Biostatistics

Biology students’ understanding of statistics is incomplete due to poor integration of these two disciplines. In some cases, students fail to learn statistics at the undergraduate level due to poor student interest and cursory teaching of...

Courses: Ecology Ecology Introductory Biology Science Process Skills

biostatisticshypothesis testingexperimental design

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6439

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1113

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Mapping a Mutation to its Gene: The "Fly Lab" as a Modern Research Experience

Although genetics is an invaluable part of the undergraduate biology curriculum, it can be intimidating to students as well as instructors: Students must reduce their reliance on memorization and dive deep into quantitative analysis, and...

Courses: Biochemistry and Molecular Biology Bioinformatics Genetics Science Process Skills

geneticsbioinformaticsdrosophilachi-square analysiscomplementation mappingmode of inheritancethree-point mapping

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285

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Using Gamification to Teach Undergraduate Students about Scientific Writing

Despite its importance, scientific writing is often deprioritized in undergraduate biology classes. Reasons include assumed prior knowledge, lack of class time, tedious grading, and the complexity and challenges associated with quality writing. To...

Courses: Science Process Skills

gamificationscientific writingE-LearningInstant FeedbackInteractive LearningReading Scientific PapersVIdeo/computer game

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340

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Cutthroat trout in Colorado: A case study connecting evolution and conservation

Evaluation of evidence is a key process skill for the core competencies of applying the process of science and using quantitative reasoning. This case study enables upper-division biology students to practice these skills by applying evolutionary...

Courses: Evolution Genetics Science Process Skills

population geneticsphylogeneticsSpeciationdivergencegene flow

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3455

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720

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Homologous chromosomes? Exploring human sex chromosomes, sex determination and sex reversal using bioinformatics approaches

Constructing a robust understanding of homologous chromosomes, sex chromosomes, and the particulate nature of genes is a notoriously difficult task for undergraduate biology students. In this lesson, students expand their knowledge of human...

Courses: Bioinformatics Genetics Introductory Biology Science Process Skills

bioinformaticsautosomehomologous chromosomeshomologous recombinationsex chromosomesex determinationsex reversal mutations

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1884

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471

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Why do Some People Inherit a Predisposition to Cancer? A small group activity on cancer genetics

Before undergraduate students take a genetics course they generally know cancer has a genetic basis and involves the proliferation of cells; however, many are uncertain about why only a subset of people have a predisposition to cancer and how that...

Courses: Genetics Science Process Skills

cancerInheritance patternsProbability calculationProto-oncogeneTumor Suppressor Gene

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614

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Predicting and classifying effects of insertion and deletion mutations on protein coding regions

Mutations in genes can affect the encoded proteins in multiple ways, and some of these effects are counterintuitive. As for any other knowledge, students must create their own deep understanding of the Central Dogma. Students may not develop this...

Courses: Bioinformatics Genetics Science Process Skills

mutationcentral dogmatranslationframeshift

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1999

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352

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Interactive Video Vignettes (IVVs) to Help Students Learn Genetics Concepts

Many video resources exist to teach Mendelian genetics, but most consist of passive delivery of information rather than active construction of knowledge by users. We have created two interactive video vignettes (IVVs) that can be used together or...

Courses: Genetics Introductory Biology Science Process Skills

genotypephenotypeallelespedigreedominanceHardy-Weinberg equilibriumInheritance

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Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Introductory Biology (identifying new promoters)

Students often memorize the definition of a transcriptional promoter but fail to fully understand the critical role promoters play in gene expression. This laboratory lesson allows students to conduct original research by identifying and...

Courses: Genetics Introductory Biology Science Process Skills

bacteriasynthetic biologygene regulationtranscriptionstudent researchcentral dogmacloningpromoterreporter gene/protein

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1859

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625

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A Close-Up Look at PCR

The Polymerase Chain Reaction (PCR) is a fundamental laboratory technique that allows for the amplification of many copies of a desired DNA target sequence. Despite its prevalence, undergraduate students often have poor comprehension about the...

Courses: Biochemistry and Molecular Biology Genetics Introductory Biology Science Process Skills

PCRDNA replication

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2761

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691

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Teaching Biodiversity with Museum Specimens in an Inquiry-Based Lab

In response to the growth of biology datasets and broad efforts to digitize data, an increasingly important skill for science students is the management and analysis of large datasets. We designed an inquiry-based lab module to introduce students...

Courses: Ecology Ecology Evolution Introductory Biology Science Process Skills

data analysisnatural historyphylogenyBiodiversitymammalsAllen's RuleBergmann's Ruleecogeographymuseum research

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3045

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731

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Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Genetics (analyzing mutant promoters)

Students often memorize the definition of a transcriptional promoter but fail to fully understand the critical role promoters play in gene expression. This laboratory lesson allows students to conduct original research by characterizing...

Courses: Genetics Science Process Skills

bacteriasynthetic biologygene regulationtranscriptionstudent researchcentral dogmacloningpromoterreporter gene/protein

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A 360˚ View of COVID-19

Exploration of the Human Genome by Investigation of Personalized SNPs

The Case of the Missing Strawberries: RFLP analysis

Teaching Genetic Linkage and Recombination through Mapping with Molecular Markers

Moths and Frogs and E. coli, Oh My!: Agent-based Modeling of Evolutionary Systems

Does it pose a threat? Investigating the impact of Bt corn on monarch butterflies

"Reading groups" in an undergraduate biology course: A peer-based model to help students develop skills to evaluate primary literature

Building a Model of Tumorigenesis: A small group activity for a cancer biology/cell biology course

Outside the Norm: Using Public Ecology Database Information to Teach Biostatistics

Mapping a Mutation to its Gene: The "Fly Lab" as a Modern Research Experience

Using Gamification to Teach Undergraduate Students about Scientific Writing

Cutthroat trout in Colorado: A case study connecting evolution and conservation

Homologous chromosomes? Exploring human sex chromosomes, sex determination and sex reversal using bioinformatics approaches

Why do Some People Inherit a Predisposition to Cancer? A small group activity on cancer genetics

Predicting and classifying effects of insertion and deletion mutations on protein coding regions

Interactive Video Vignettes (IVVs) to Help Students Learn Genetics Concepts

Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Introductory Biology (identifying new promoters)

A Close-Up Look at PCR

Teaching Biodiversity with Museum Specimens in an Inquiry-Based Lab

Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Genetics (analyzing mutant promoters)

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