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    A 360˚ View of COVID-19
    In March 2020, institutions underwent a massive transition to distance learning as a result of the COVID-19 pandemic. With so little time to devise new materials to maximize learning in the new virtual environment, instructors devised a variety of...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology BioinformaticsBioinformatics Cell BiologyCell Biology EvolutionEvolution GeneticsGenetics ImmunologyImmunology Introductory BiologyIntroductory Biology MicrobiologyMicrobiology Science Process SkillsScience Process Skills

    geneticsImmunologyBiochemistrybioinformaticsmolecular evolutionpublic healthvirusCOVID19
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    It's a Substrate... It's a Protein...No - It's an Enzyme! Teaching Using 3D Serine Protease Physical Modeling Activities to Confront Misconceptions.
    Reported misconceptions of enzyme-substrate interactions highlight the necessity for better, targeted instructional tools and assessments. A series of active learning activities with corresponding three-dimensional (3D) physical models were...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology

    Protein StructureEnzymes-Substrate InteractionsNoncovalent InteractionsGeometric ComplementaryElectronicsStereochemistrySerine Proteases
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    Exploring Miracle Fruit: An Undergraduate Laboratory Exercise on Experimental Design
    In recent years, undergraduate biology and biochemistry curricula have seen an increase in the use of course-based undergraduate research experiences (CUREs). CUREs maximize potential student gains when students take an active role in experimental...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Science Process SkillsScience Process Skills

    sensory systemspHProtein shapeTaste
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    Single Cell Insights Into Cancer Transcriptomes: A Five-Part Single-Cell RNAseq Case Study Lesson
    There is a growing need for integration of “Big Data” into undergraduate biology curricula. Transcriptomics is one venue to examine biology from an informatics perspective. RNA sequencing has largely replaced the use of microarrays for whole...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology BioinformaticsBioinformatics Cell BiologyCell Biology GeneticsGenetics Introductory BiologyIntroductory Biology

    bioinformaticscancertranscriptomicshigh-throughputData wranglingSingle cell RNA sequencingq
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    Lights, Camera, Acting Transport! Using role-play to teach membrane transport
    Lights, Camera, Acting Transport! is an active and unique role-play exercise designed to teach introductory biology students basic concepts of passive and active membrane transport. The activity involves three acts in which students, representing...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Cell BiologyCell Biology Introductory BiologyIntroductory Biology

    ATPcarrierschannelsco-transportelectrogenic pumpfacilitated diffusionmembrane transportpassive transportprimary active transportsimple diffusion
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    Understanding Protein Domains: A Modular Approach
    An understanding of protein structure, function, and interaction is central to biochemistry. One angle into this topic is to engage students in considering protein domains as modules that develop form and execute function semi-independently. Here,...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Cell BiologyCell Biology Science Process SkillsScience Process Skills

    Protein Structure
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    CRISPR/Cas9 in yeast: a multi-week laboratory exercise for undergraduate students
    Providing undergraduate life-science students with a course-based research experience that utilizes cutting-edge technology, is tractable for students, and is manageable as an instructor is a challenge. Here, I describe a multi-week lesson plan...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology BioinformaticsBioinformatics GeneticsGenetics MicrobiologyMicrobiology Science Process SkillsScience Process Skills

    bioinformaticsPCRphenotypingCRISPR/Cas9gene editingcloningGenotypingRestriction enzyme
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    A Simple Method for Predicting a Molecule's Biological Properties From Its Polarity
    The distinction between very polar and less polar substances is a foundation of biochemistry, cell biology, and physiology; it surfaces in multiple concept inventories and elaborations of biological core concepts. However, in our experience, most...

    Courses: Anatomy-PhysiologyAnatomy-Physiology Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Cell BiologyCell Biology Introductory BiologyIntroductory Biology

    Diffusionsolubilitycovalent bondshydrophilichydrophobicpartition coefficientplasma membranepolarity
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    Investigating Enzyme Structure and Function Through Model-Building and Peer Teaching in an Introductory Biology Course
    A foundational knowledge of the relationship between structure and function is critical to understanding how enzymes work. The seemingly invisible nature of these molecular interactions makes it challenging for undergraduate students to...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Introductory BiologyIntroductory Biology

    structure-functionEnzymeallosteric regulationcompetitive inhibitionfeedback inhibitionnoncompetitive inhibitionproductsubstrate
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    Using Open-Source Bioinformatics and Visualization Tools to Explore the Structure and Function of SARS-CoV-2 Spike Protein
    The relationship between protein structure and function is a foundational concept in undergraduate biochemistry. We find this theme is best presented with assignments that encourage exploration and analysis. Here, we share a series of four...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology BioinformaticsBioinformatics Science Process SkillsScience Process Skills

    bioinformaticsmolecular modelingCOVID19protein structure and functionUCSF ChimeraSARS-CoV-2 spike proteinACE2 receptor
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    Breaking Bricks: A Hands-On Model of Enzyme Kinetics and Inhibition
    Enzyme kinetics and the impacts of inhibitors on the enzyme's maximal velocity and ability to bind substrates are important topics in cell biology and biochemistry. However, these topics can be difficult for students to grasp when instructed...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Cell BiologyCell Biology

    kineticsEnzymecompetitive inhibition