CourseSource: Resources

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Linking Genotype to Phenotype: The Effect of a Mutation in Gibberellic Acid Production on Plant Germination

Basic concepts in genetics and plant development are often taught in lecture courses without a lab component. This approach provides students with the content knowledge, but fails to make connections to research opportunities and real-world...

Courses: Cell Biology Developmental Biology Genetics Introductory Biology Plant Biology

geneticsdevelopmentmutationgerminationplantmodel organismGenotype/PhenotypeHormoneSeed

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1691

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494

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Sex-specific differences in Meiosis: Real-world applications

In traditional classrooms, students are typically presented with facts that they are asked to memorize and recall during an exam. The rapid explosion of available scientific facts in recent years has made this model of teaching...

Courses: Cell Biology Genetics Science Process Skills

meiosisReproductionAneuploidyGameteNon-disjunctionOocyteSpermTrisomy

Science Behind the Lesson

2003

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294

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The Science Behind Parthenogenesis: Interesting things happen when meiosis goes “wrong”

Parthenogenetic reproduction is a fascinating, complex topic. This article accompanies “Why Meiosis Matters: The case of the fatherless snake.” It summarizes the basic information an introductory biology or genetics instructor...

Courses: Cell Biology Genetics Introductory Biology

meiosismitosissex determinationAsexual reproductionParthenogenesis

Teaching Tools and Strategies

3635

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1718

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A 360˚ View of COVID-19

In March 2020, institutions underwent a massive transition to distance learning as a result of the COVID-19 pandemic. With so little time to devise new materials to maximize learning in the new virtual environment, instructors devised a variety of...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Evolution Genetics Immunology Introductory Biology Microbiology Science Process Skills

geneticsImmunologyBiochemistrybioinformaticsmolecular evolutionpublic healthvirusCOVID19

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1248

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65

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Defining Life: Exploring Creativity, Scientific Discovery, and Biology Core Concepts in a Disciplinary First-Year Seminar

This unit, Defining Life, engages students in thinking like scientists, applying creativity to science, and learning biology core concepts as they explore the defining characteristics of life. This unit provides an example of a curriculum designed...

Courses: Biochemistry and Molecular Biology Cell Biology Evolution Genetics Introductory Biology Microbiology Science Process Skills

Evolutionbiologycellprocess of science

Teaching Tools and Strategies

1733

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325

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SCIENCE/Fiction: Modular Template for Class Design

We present a modular scaffold for designing an introductory seminar using speculative fiction and science papers to welcome university undergraduates to the biology major. A list of twelve possible topics is included, such as Memory, Parasites,...

Courses: Anatomy-Physiology Biochemistry and Molecular Biology Cell Biology Evolution Genetics Introductory Biology Neurobiology

geneticscell biologyneurosciencesystems biologyScience Fiction

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6612

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1646

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Single Cell Insights Into Cancer Transcriptomes: A Five-Part Single-Cell RNAseq Case Study Lesson

There is a growing need for integration of “Big Data” into undergraduate biology curricula. Transcriptomics is one venue to examine biology from an informatics perspective. RNA sequencing has largely replaced the use of microarrays for whole...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Genetics Introductory Biology

bioinformaticscancertranscriptomicshigh-throughputData wranglingSingle cell RNA sequencingq

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2141

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496

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Necessary and Sufficient? Solving the Mystery of the Mitochondrial Pyruvate Transporter

While there are several available lessons for teaching introductory biology students about diffusion, facilitated diffusion, and active transport, fewer materials exist to support upper-division students' understanding of the proteins that...

Courses: Cell Biology

DiffusionActive transportfacilitated diffusionNecessary and sufficientTransport proteins

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9397

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562

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Manuscript 101: A Data-Driven Writing Exercise for Beginning Scientists

Learning to write a scientific manuscript is one of the most important and rewarding scientific training experiences, yet most young scientists only embark on this experience relatively late in graduate school after gathering sufficient data in...

Courses: Bioinformatics Cell Biology Developmental Biology Genetics Microbiology Science Process Skills

geneticsanimaldevelopmentcompetitionbacterial

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4108

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596

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Splicing it Together: Using Primary Data to Explore RNA Splicing and Gene Expression in Large-Lecture Introductory Biology

At the heart of scientific ways of knowing is the systematic collection and analysis of data, which is then used to propose an explanation of how the world works. In this two-day module, students in a large-lecture course are immersed in a...

Courses: Biochemistry and Molecular Biology Cell Biology Genetics Introductory Biology

gene regulationtranscriptiongene expressioncentral dogmarepressoralternative splicingmRNA processingActivatorTranscription factors

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2584

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202

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A Laboratory Module That Explores RNA Interference and Codon Optimization Through Fluorescence Microscopy Using Caenorhabditis elegans

Scientific research experiences are beneficial to students allowing them to gain laboratory and problem-solving skills, as well as foundational research skills in a team-based setting. We designed a laboratory module to provide a guided research...

Courses: Bioinformatics Cell Biology Developmental Biology Genetics Science Process Skills

microscopyC. elegansquantitative analysisinquiry-based learninggene expressionRNA interferenceCodon UsageLaboratory Module

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A CRISPR/Cas Guide RNA Design In Silico Activity

CRISPR biotechnologies inspired by the Clustered Regularly Interspaced Short Palindromic Repeat RNA-guided nuclease adaptive bacterial immune system have revolutionized biology research and become ubiquitous tools for hypothesis and...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Genetics

bioinformaticsgene expressiongenetic basis of diseaseCRISPR/Cas9genetic engineeringin silico

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5547

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Cell Signaling Pathways - a Case Study Approach

Signaling and gene expression are fundamental to cell biology and developmental biology. Although these topics are highly interrelated, they typically appear in separate units in a course. We use a series of short problem-based learning exercises...

Courses: Cell Biology Developmental Biology

signal transductiongene expressionCell communicationgenetic disordersregulation of enzyme activity

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2890

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505

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GMC: Genes, Mutations and Cancer - Group Concept Map Development

It has been shown that active learning strategies used in the classroom can increase student learning and retention of information. We generated an active learning exercise that can be used in the classroom to explore the relationship between...

Courses: Cell Biology Genetics Introductory Biology

mutationcancerCell Division

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Building a Model of Tumorigenesis: A small group activity for a cancer biology/cell biology course

The multistep nature of tumorigenesis is a foundational concept in the context of Cancer Biology. Many students do not appreciate the complex nature of cancer development nor do they understand how scientists are able to unravel the molecular...

Courses: Cell Biology Genetics Science Process Skills

pathwayscancerMolecular AlterationsRetrospective dataTumorigenesis

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Understanding the Importance of Microtubules in Normal Cell Division: Chemotherapy Connection

In introductory courses, students learn about microtubules as important structures but may not engage in a hands-on experience to localize microtubules themselves or to learn about their connection to cancer treatment. In this lesson, students...

Courses: Biochemistry and Molecular Biology Cell Biology Genetics

cancerCell DivisionimmunofluorescenceMicrotubulesAntibodies

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Does Organelle Shape Matter?: Exploring Patterns in Cell Shape and Structure with High-Throughput (HT) Imaging

Organelle structure has been studied and visualized for decades; however, publicly available databases that use improved high-throughput microscopy of gene-edited cell lines have recently revolutionized the amount and quality of information now...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Genetics Science Process Skills

modelingcase studymicroscopystructureOrganellesHigh-throughput (HT)Endoplasmic Reticulum (ER)Fluorescent microscopyHuman Cell Biology

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How to Find a Gene: Retrieving Information From Gene Databases

A strong understanding of distinct gene components and the ability to retrieve relevant information from gene databases are necessary to answer a diverse set of biological questions. However, often there is a considerable gap between...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Genetics Introductory Biology

NCBItranscriptiontranslationGene StructureGene databasesEnsembl

Essay

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Structuring Courses for Equity

As instructors, we continually look for new ways to create equitable learning environments and support learning for all students in our courses. Recently, we have explored ways that we can increase structure to better support students. We have...

Courses: Anatomy-Physiology Bioinformatics Cell Biology Developmental Biology Ecology Ecology Genetics Introductory Biology Microbiology Neurobiology Plant Biology Science Process Skills

Equitymetacognitioninclusivitycourse structure

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Application of a Bacterial Experimental Evolution System to Visualize and Teach Evolution in Action: A Course-Based Undergraduate Research Experience

Concepts of evolution are typically taught through examples of extremely long timescales, which do not always resonate broadly. Here, we describe a course-based undergraduate research experience tailored for junior and senior undergraduate biology...

Courses: Biochemistry and Molecular Biology Bioinformatics Cell Biology Evolution Genetics Microbiology

EvolutionmutationcompetitionNatural Selectionregulationstructure and functionreproductive fitnessgenotype to phenotypehomologs

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Linking Genotype to Phenotype: The Effect of a Mutation in Gibberellic Acid Production on Plant Germination

Sex-specific differences in Meiosis: Real-world applications

The Science Behind Parthenogenesis: Interesting things happen when meiosis goes “wrong”

A 360˚ View of COVID-19

Defining Life: Exploring Creativity, Scientific Discovery, and Biology Core Concepts in a Disciplinary First-Year Seminar

SCIENCE/Fiction: Modular Template for Class Design

Single Cell Insights Into Cancer Transcriptomes: A Five-Part Single-Cell RNAseq Case Study Lesson

Necessary and Sufficient? Solving the Mystery of the Mitochondrial Pyruvate Transporter

Manuscript 101: A Data-Driven Writing Exercise for Beginning Scientists

Splicing it Together: Using Primary Data to Explore RNA Splicing and Gene Expression in Large-Lecture Introductory Biology

A Laboratory Module That Explores RNA Interference and Codon Optimization Through Fluorescence Microscopy Using Caenorhabditis elegans

A CRISPR/Cas Guide RNA Design In Silico Activity

Cell Signaling Pathways - a Case Study Approach

GMC: Genes, Mutations and Cancer - Group Concept Map Development

Building a Model of Tumorigenesis: A small group activity for a cancer biology/cell biology course

Understanding the Importance of Microtubules in Normal Cell Division: Chemotherapy Connection

Does Organelle Shape Matter?: Exploring Patterns in Cell Shape and Structure with High-Throughput (HT) Imaging

How to Find a Gene: Retrieving Information From Gene Databases

Structuring Courses for Equity

Application of a Bacterial Experimental Evolution System to Visualize and Teach Evolution in Action: A Course-Based Undergraduate Research Experience

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