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    3396

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    713

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    Homologous chromosomes? Exploring human sex chromosomes, sex determination and sex reversal using bioinformatics approaches
    Constructing a robust understanding of homologous chromosomes, sex chromosomes, and the particulate nature of genes is a notoriously difficult task for undergraduate biology students. In this lesson, students expand their knowledge of human...

    Courses: BioinformaticsBioinformatics GeneticsGenetics Introductory BiologyIntroductory Biology Science Process SkillsScience Process Skills

    bioinformaticsautosomehomologous chromosomeshomologous recombinationsex chromosomesex determinationsex reversal mutations
    Lesson
    5509

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    1133

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    3

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    Meiosis: A Play in Three Acts, Starring DNA Sequence
    Meiosis is well known for being a sticky topic that appears repeatedly in biology curricula. We observe that a typical undergraduate biology major cannot correctly identify haploid and diploid cells or explain how and why chromosomes pair before...

    Courses: Cell BiologyCell Biology GeneticsGenetics Introductory BiologyIntroductory Biology

    recombinationmeiosisDNA sequenceCrossingoverchromosome structureHolliday junctionhomology
    Lesson
    9061

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    1165

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    Why Meiosis Matters: The case of the fatherless snake
    A compelling reason to learn something can make all the difference in students’ motivation to learn it.  Motivation, in turn, is one of the key attitudes that drives learning.  This story presents students with a compelling puzzle of a...

    Courses: GeneticsGenetics Science Process SkillsScience Process Skills

    meiosismitosissex determinationAsexual reproductionParthenogenesis
    Lesson
    6079

    views

    523

    downloads

    2

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    Meiosis Remodeled: Inclusion of New Parts to Poppit Bead Models Enhances Understanding of Meiosis
    A long-standing tradition uses strings of poppit beads of different colors to model meiosis, especially to show how segments of paired homologous chromosomes are recombined. Our use of orthodontic latex bands to model cohesion of sister...

    Courses: Cell BiologyCell Biology GeneticsGenetics Introductory BiologyIntroductory Biology

    meiosischiasma formationchromosome recombination
    Lesson
    1580

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    235

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    0

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    Make It Stick: Teaching Gene Targeting with Ribbons and Fasteners
    Manipulating gene expression is a commonly used tool to study the effect of a single gene or the hierarchy of gene networks in many different biological disciplines. When working with mice, the most commonly used techniques to manipulate genes...

    Courses: Developmental BiologyDevelopmental Biology GeneticsGenetics

    mathematical modelhomologous recombinationCre/loxgene targeting
    Lesson
    1915

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    274

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    A CURE-based approach to teaching genomics using mitochondrial genomes
    There is an abundance (currently over 1016 DNA bases) of publicly available genetic sequence data and a dearth of trained genomicists to process and interpret it, necessitating more trained bioinformaticians with biological expertise. For...

    Courses: BioinformaticsBioinformatics GeneticsGenetics

    proteinsMitochondrial GenomesNuclear GenomesrRNAtRNA
    Lesson
    2008

    views

    381

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    0

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    Integrating Manipulatives and Animations to Visualize Holliday Junctions
    The complex molecular architecture of Holliday junctions is often challenging for undergraduate biochemistry students to conceptualize. In particular, they have difficulty translating from two-dimensional, linear representations shown in textbooks...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology GeneticsGenetics

    dna structureDNA damageDNA recombinationGene crossoverHolliday junction
    Lesson
    11759

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    1809

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    2

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    A virtual laboratory on cell division using a publicly-available image database
    Cell division is a key concept in cell biology. While there are many popular activities to teach students the stages of mitosis, most make use of simple schematics, cartoons, or textbook diagrams. Others engage students in acting out the stages,...

    Courses: Cell BiologyCell Biology Science Process SkillsScience Process Skills

    image analysismicroscopymitosisCellular Processes
    Lesson
    2334

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    230

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    0

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    Sex and gender: What does it mean to be female or male?
    This lesson provides three activities to engage non-science major students in a discussion about sex, gender, gender identity, and sex determination. Students prepare for the lesson by reading a short article titled Sex and gender: What is the...

    Courses: Anatomy-PhysiologyAnatomy-Physiology Introductory BiologyIntroductory Biology

    gendersex determinationgender identitysex
    Lesson
    2010

    views

    510

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    0

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    Using Immunocytochemistry and Fluorescence Microscopy Imaging to Explore the Mechanism of Action of Anti-Cancer Drugs on the Cell Cycle
    Understanding and visualizing the cell cycle and mitosis is an essential concept of cell biology. This multi-week lab module has students investigate the mechanism of action of anti-cancer drugs that disrupt activities associated with mitosis and...

    Courses: Cell BiologyCell Biology Science Process SkillsScience Process Skills

    fluorescence microscopymitosisCell StructureCell ImagingImmunocytochemistryQuantitative microscopySTEM skills
    Lesson
    4616

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    1785

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    0

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    Teaching Genetic Linkage and Recombination through Mapping with Molecular Markers
    Most introductory genetics courses cover genetic linkage, a core concept in the CourseSource genetics learning outcome framework. Although it is a classical genetics topic, genetic linkage remains an important concept to understand in order to...

    Courses: GeneticsGenetics Plant BiologyPlant Biology Science Process SkillsScience Process Skills

    meiosisphenotypegel electrophoresismicrosatellitesBanding PatternGenetic linkageInheritanceMolecular MarkersPhysical Linkage
    Lesson
    2712

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    648

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    0

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    The Case of the Missing Strawberries: RFLP analysis
    While solving the fictional mystery of the missing strawberries, students are engaged in a guided-inquiry lesson featuring small-group and class discussions, hands-on activities, and laboratory exercises related to molecular genotyping by...

    Courses: GeneticsGenetics Science Process SkillsScience Process Skills

    process of scienceDNAforensicsgel electrophoresisMolecular genotypingRestriction endonucleaseRestriction enzymeRestriction fragment length polymorphismRFLP
    Lesson
    330

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    43

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    The Science and Ethics of Gene Drives: An Active Learning Lesson in Genetics
    Coursework connecting biology to socially relevant issues and ethical questions can help students think about biology in interdisciplinary terms. Gene drives represent one topic involving both advanced biology concepts and societally relevant...

    Courses: GeneticsGenetics

    bioethicsCRISPR/Cas9Genetic modificationGene drives
    Lesson
    3243

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    1149

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    CRISPR/Cas9 in yeast: a multi-week laboratory exercise for undergraduate students
    Providing undergraduate life-science students with a course-based research experience that utilizes cutting-edge technology, is tractable for students, and is manageable as an instructor is a challenge. Here, I describe a multi-week lesson plan...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology BioinformaticsBioinformatics GeneticsGenetics MicrobiologyMicrobiology Science Process SkillsScience Process Skills

    bioinformaticsPCRphenotypingCRISPR/Cas9gene editingcloningGenotypingRestriction enzyme
    Lesson
    2066

    views

    651

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    1

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    Sequence Similarity: An inquiry based and "under the hood" approach for incorporating molecular sequence alignment in introductory undergraduate biology courses
    Introductory bioinformatics exercises often walk students through the use of computational tools, but often provide little understanding of what a computational tool does "under the hood." A solid understanding of how a bioinformatics...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology BioinformaticsBioinformatics Introductory BiologyIntroductory Biology

    BLASTmultiple sequence alignmentsequence similarityphylogramZika virusAlgorithmScoring Matrix
    Lesson
    3449

    views

    60

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    0

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    The Great Petunia Carnage of 2017: A Clicker Case Study Using Petunias to Describe the Effect of Genetic Modification on the Biochemistry of Flower Color and Phenotype in Plants
    In this single class period case study, students examine the difference between genotype and phenotype by studying the mechanisms by which commercially available petunias have been bred to have different phenotypes (flower colors). Students review...

    Courses: GeneticsGenetics Introductory BiologyIntroductory Biology Plant BiologyPlant Biology

    case studyGenetic ModificationsBiochemistry of Flower ColorGMO regulationsGenotype-Phenotype Connections
    Lesson
    465

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    66

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    0

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    Using Raw Sequence Data to Analyze Tumor Suppressor Mutations
    Learning to identify DNA sequence variants from raw sequencing data (electropherograms) is a basic molecular biology skill with applications to basic research and clinical practice. Yet learning to map DNA sequence variants to functional regions...

    Courses: BioinformaticsBioinformatics GeneticsGenetics

    bioinformaticsmutationDNAgenomic visualizationparts of a geneclinical consequencesraw data
    Lesson
    1122

    views

    113

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    0

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    Understanding the Importance of Microtubules in Normal Cell Division: Chemotherapy Connection
    In introductory courses, students learn about microtubules as important structures but may not engage in a hands-on experience to localize microtubules themselves or to learn about their connection to cancer treatment. In this lesson, students...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Cell BiologyCell Biology GeneticsGenetics

    cancerCell DivisionimmunofluorescenceMicrotubulesAntibodies
    Lesson
    2214

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    296

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    0

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    Learning Quantitative Genetics: Investigation of Genetic Control for Cold Stress Response in Plants
    Course-embedded undergraduate research experiences (CUREs) for students have been shown to increase students’ understanding of the process of science, affirm their scientific identity, and improve retention in STEM fields. Despite many CUREs...

    Courses: GeneticsGenetics

    data analysisrecombinationplantsquantitative geneticsabiotic stress responsegenetic control of complex traitsinheritance of complex traits
    Lesson
    3014

    views

    889

    downloads

    1

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    Fruit Fly Genetics in a Day: A Guided Exploration to Help Many Large Sections of Beginning Students Uncover the Secrets of Sex-linked Inheritance
    Moving beyond the basic concepts of autosomal Mendelian inheritance to sex-linkage can be difficult for introductory biology students. Although crosses with Drosophila fruit flies have long been a mainstay of genetics units that teach these...

    Courses: GeneticsGenetics

    Mendelian Geneticsfruit fly biologysex-linked inheritance