CourseSource: Resources

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Why do Some People Inherit a Predisposition to Cancer? A small group activity on cancer genetics

Before undergraduate students take a genetics course they generally know cancer has a genetic basis and involves the proliferation of cells; however, many are uncertain about why only a subset of people have a predisposition to cancer and how that...

Courses: Genetics Science Process Skills

cancerInheritance patternsProbability calculationProto-oncogeneTumor Suppressor Gene

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1392

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395

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Where Does Elsie's Hair Color Come From? A "De-Simplified" Pedigree Lesson

Pedigree analysis is part of most Genetics curricula, but the examples traditionally used in genetics courses present phenotypes as if they were entirely and inexorably defined by genotype. This does not reflect the current state of understanding...

Courses: Genetics Introductory Biology

pedigreeMultifactorialphenotypic variationpenetranceexpressivityquantitative variation

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3143

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897

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Fruit Fly Genetics in a Day: A Guided Exploration to Help Many Large Sections of Beginning Students Uncover the Secrets of Sex-linked Inheritance

Moving beyond the basic concepts of autosomal Mendelian inheritance to sex-linkage can be difficult for introductory biology students. Although crosses with Drosophila fruit flies have long been a mainstay of genetics units that teach these...

Courses: Genetics

Mendelian Geneticsfruit fly biologysex-linked inheritance

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6521

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1119

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Mapping a Mutation to its Gene: The "Fly Lab" as a Modern Research Experience

Although genetics is an invaluable part of the undergraduate biology curriculum, it can be intimidating to students as well as instructors: Students must reduce their reliance on memorization and dive deep into quantitative analysis, and...

Courses: Biochemistry and Molecular Biology Bioinformatics Genetics Science Process Skills

geneticsbioinformaticsdrosophilachi-square analysiscomplementation mappingmode of inheritancethree-point mapping

Lesson

1584

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340

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Real World Scenarios in Non-Majors Biology

Students in non-majors’ biology courses may not choose careers that require biology content knowledge; however, all will encounter science in their lives. We redesigned a non-majors introductory biology course to support students in...

Courses: Introductory Biology Science Process Skills

geneticsVaccinesScientific ProcessGMOsviruses

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2026

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357

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Interactive Video Vignettes (IVVs) to Help Students Learn Genetics Concepts

Many video resources exist to teach Mendelian genetics, but most consist of passive delivery of information rather than active construction of knowledge by users. We have created two interactive video vignettes (IVVs) that can be used together or...

Courses: Genetics Introductory Biology Science Process Skills

genotypephenotypeallelespedigreedominanceHardy-Weinberg equilibriumInheritance

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3762

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285

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Fragile States: A Case Study Exploring Genetics, Molecular Biology, and Biochemistry Through the Lens of Fragile X Syndrome

This case aims to strengthen students’ understanding of molecular biology concepts through study of Fragile X Syndrome (FXS). Students begin by learning the cause and phenotypes of FXS and related conditions. Students then apply genetics...

Courses: Biochemistry and Molecular Biology Genetics

gene regulationtranscriptiontranslationFragile X syndrometriplet repeat expansionsex linkagemetabolic pathway

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2278

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305

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Learning Quantitative Genetics: Investigation of Genetic Control for Cold Stress Response in Plants

Course-embedded undergraduate research experiences (CUREs) for students have been shown to increase students’ understanding of the process of science, affirm their scientific identity, and improve retention in STEM fields. Despite many CUREs...

Courses: Genetics

data analysisrecombinationplantsquantitative geneticsabiotic stress responsegenetic control of complex traitsinheritance of complex traits

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3162

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404

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Honoring the Complexity of Genetics: Exploring the Role of Genes and the Environment Using Real World Examples

Historically, undergraduate genetics courses have disproportionately focused on the impact of genes on phenotypes, rather than multifactorial concepts which consider how a combination of genes, the environment, and gene-by-environment interactions...

Courses: Evolution Genetics Introductory Biology

genesenvironmentMendelQuantitative traitsMultifactorialGene by environment interactions

Science Behind the Lesson

656

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58

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X-ploring Fragile X: The Science Behind the Syndrome

Fragile X Syndrome is an X-linked genetic disorder resulting from the impairment of transcription of the FMR1 gene, producing less to no FMRP protein. FMRP is a translational inhibitor that plays a key role in neurological development. Recent...

Courses: Biochemistry and Molecular Biology Genetics Introductory Biology

epigeneticsgene regulationtranscriptioncentral dogmatranslationFragile X syndromeSphingosine Metabolism

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3469

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724

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Homologous chromosomes? Exploring human sex chromosomes, sex determination and sex reversal using bioinformatics approaches

Constructing a robust understanding of homologous chromosomes, sex chromosomes, and the particulate nature of genes is a notoriously difficult task for undergraduate biology students. In this lesson, students expand their knowledge of human...

Courses: Bioinformatics Genetics Introductory Biology Science Process Skills

bioinformaticsautosomehomologous chromosomeshomologous recombinationsex chromosomesex determinationsex reversal mutations

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3406

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285

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Garden Variety Mutations: Using Primary Data to Understand the Central Dogma in Large-Lecture Introductory Biology

The ability to interpret and create an argument from data is a crucial skill for budding scientists, yet one that is seldom practiced in introductory courses. During this argumentation module, students in a large lecture class will work in groups...

Courses: Biochemistry and Molecular Biology Genetics Introductory Biology

mutationtranscriptiongene expressioncentral dogmatranslationgel electrophoresisGenotype/Phenotype

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2993

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A Muscular Dystrophy Case Study Illustrating the Phenotypic Effects of Mutation

Mutations in genes can lead to a variety of phenotypes, including various human diseases. Students often understand that a particular mutation in a single gene causes a disease phenotype, but it is more challenging to illustrate complex genetic...

Courses: Developmental Biology Genetics

mutationProtein Structureethicscentral dogmahuman disease

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1881

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350

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Engaging Students in Pharmacogenetics: Patient Case Studies Using the PharmGKB Website

Cytochrome P450 (CYP) enzymes are important regulators of drug efficacy and toxicity. Genetic variation in CYP isoforms can impact how well patients respond to medications or experience unwanted toxicities. PharmGKB is an online pharmacogenomics...

Courses: Genetics Toxicology

toxicologyPharmacologydrug metabolismpharmacodynamicspharmacogenetics

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3670

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1005

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A Quick and Simple Natural Selection Role Play

Teaching evolution remains a challenging task in biology education. Students enter the classroom with stubborn misconceptions and many traditional examples of the process of evolution may not resonate with students. This short role play activity...

Courses: Ecology Ecology Evolution Genetics Plant Biology

EvolutionfitnessNatural Selectionheritability

Teaching Tools and Strategies

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Biology from Molecules to Embryos, Interactive Animated Lessons

Visualizing kinetic processes can be an impediment to student mastery of basic science coursework. To remedy this obstacle, I created an educational program called Biology from Molecules to Embryos© (BioME), which provides 28 animated lessons...

Courses: Developmental Biology Genetics Introductory Biology

geneticsBIOMEEmbryologycomputer assisted instructioneducational programeducational videosonline lessonsanimated lessonseducational website

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Teaching epidemiology and principles of infectious disease using popular media and the case of Typhoid Mary

Allied health students often struggle to understand how particular content, such as epidemiology, connects to their future careers. This activity uses the case of Typhoid Mary as a foundation for exploring epidemiology and infectious disease...

Courses: Microbiology Science Process Skills

epidemiologycase studyinfectous diseasepopular mediaTyphoid Mary

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Why Meiosis Matters: The case of the fatherless snake

A compelling reason to learn something can make all the difference in students’ motivation to learn it. Motivation, in turn, is one of the key attitudes that drives learning. This story presents students with a compelling puzzle of a...

Courses: Genetics Science Process Skills

meiosismitosissex determinationAsexual reproductionParthenogenesis

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Mock Drug Activity Enhances Student Learning About the Challenges of HIV/AIDS Therapy

While traditional didactic coursework is important for learning about the scientific aspects of HIV/AIDS, it is difficult to convey social aspects of the epidemic. Due to effective drug therapies, an HIV diagnosis is now considered a chronic...

Courses: Microbiology

drug resistanceRetrovirusViral replication

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2642

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576

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Linking Genotype to Phenotype: The Effect of a Mutation in Gibberellic Acid Production on Plant Germination

Basic concepts in genetics and plant development are often taught in lecture courses without a lab component. This approach provides students with the content knowledge, but fails to make connections to research opportunities and real-world...

Courses: Cell Biology Developmental Biology Genetics Introductory Biology Plant Biology

geneticsdevelopmentmutationgerminationplantmodel organismGenotype/PhenotypeHormoneSeed

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Why do Some People Inherit a Predisposition to Cancer? A small group activity on cancer genetics

Where Does Elsie's Hair Color Come From? A "De-Simplified" Pedigree Lesson

Fruit Fly Genetics in a Day: A Guided Exploration to Help Many Large Sections of Beginning Students Uncover the Secrets of Sex-linked Inheritance

Mapping a Mutation to its Gene: The "Fly Lab" as a Modern Research Experience

Real World Scenarios in Non-Majors Biology

Interactive Video Vignettes (IVVs) to Help Students Learn Genetics Concepts

Fragile States: A Case Study Exploring Genetics, Molecular Biology, and Biochemistry Through the Lens of Fragile X Syndrome

Learning Quantitative Genetics: Investigation of Genetic Control for Cold Stress Response in Plants

Honoring the Complexity of Genetics: Exploring the Role of Genes and the Environment Using Real World Examples

X-ploring Fragile X: The Science Behind the Syndrome

Homologous chromosomes? Exploring human sex chromosomes, sex determination and sex reversal using bioinformatics approaches

Garden Variety Mutations: Using Primary Data to Understand the Central Dogma in Large-Lecture Introductory Biology

A Muscular Dystrophy Case Study Illustrating the Phenotypic Effects of Mutation

Engaging Students in Pharmacogenetics: Patient Case Studies Using the PharmGKB Website

A Quick and Simple Natural Selection Role Play

Biology from Molecules to Embryos, Interactive Animated Lessons

Teaching epidemiology and principles of infectious disease using popular media and the case of Typhoid Mary

Why Meiosis Matters: The case of the fatherless snake

Mock Drug Activity Enhances Student Learning About the Challenges of HIV/AIDS Therapy

Linking Genotype to Phenotype: The Effect of a Mutation in Gibberellic Acid Production on Plant Germination

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