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    The Great Petunia Carnage of 2017: A Clicker Case Study Using Petunias to Describe the Effect of Genetic Modification on the Biochemistry of Flower Color and Phenotype in Plants
    In this single class period case study, students examine the difference between genotype and phenotype by studying the mechanisms by which commercially available petunias have been bred to have different phenotypes (flower colors). Students review...

    Courses: GeneticsGenetics Introductory BiologyIntroductory Biology Plant BiologyPlant Biology

    case studyGenetic ModificationsBiochemistry of Flower ColorGMO regulationsGenotype-Phenotype Connections
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    2973

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    612

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    Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Introductory Biology (identifying new promoters)
    Students often memorize the definition of a transcriptional promoter but fail to fully understand the critical role promoters play in gene expression. This laboratory lesson allows students to conduct original research by identifying and...

    Courses: GeneticsGenetics Introductory BiologyIntroductory Biology Science Process SkillsScience Process Skills

    bacteriasynthetic biologygene regulationtranscriptionstudent researchcentral dogmacloningpromoterreporter gene/protein
    Lesson
    1731

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    422

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    How to Find a Gene: Retrieving Information From Gene Databases
    A strong understanding of distinct gene components and the ability to retrieve relevant information from gene databases are necessary to answer a diverse set of biological questions. However, often there is a considerable gap between...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology BioinformaticsBioinformatics Cell BiologyCell Biology GeneticsGenetics Introductory BiologyIntroductory Biology

    NCBItranscriptiontranslationGene StructureGene databasesEnsembl
    Lesson
    3089

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    738

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    Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Genetics (analyzing mutant promoters)
    Students often memorize the definition of a transcriptional promoter but fail to fully understand the critical role promoters play in gene expression.  This laboratory lesson allows students to conduct original research by characterizing...

    Courses: GeneticsGenetics Science Process SkillsScience Process Skills

    bacteriasynthetic biologygene regulationtranscriptionstudent researchcentral dogmacloningpromoterreporter gene/protein
    Lesson
    3140

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    502

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    Targeting Misconceptions in the Central Dogma by Examining Viral Infection
    Understanding the central dogma and how changes in gene expression can impact cell function requires integration of several topics in molecular biology. Students often do not make the necessary connections between DNA structure, transcription,...

    Courses: GeneticsGenetics Introductory BiologyIntroductory Biology

    datatranscriptionvirustranslationprotein functionmembrane transportPredictions
    Lesson
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    346

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    A Muscular Dystrophy Case Study Illustrating the Phenotypic Effects of Mutation
    Mutations in genes can lead to a variety of phenotypes, including various human diseases. Students often understand that a particular mutation in a single gene causes a disease phenotype, but it is more challenging to illustrate complex genetic...

    Courses: Developmental BiologyDevelopmental Biology GeneticsGenetics

    mutationProtein Structureethicscentral dogmahuman disease
    Lesson
    2102

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    543

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    Using computational molecular modeling software to demonstrate how DNA mutations cause phenotypes
    Students require a deep understanding of the central dogma before they can understand complex topics such as evolution and biochemical disorders. However, getting undergraduate biology students to apply higher-order thinking skills to the central...

    Courses: BioinformaticsBioinformatics GeneticsGenetics Science Process SkillsScience Process Skills

    Protein Structurecomputational modelingcentral dogmaplant leaf structurePhenotype/Genotype
    Teaching Tools and Strategies
    2184

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    356

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    DNA Detective: Genotype to Phenotype. A Bioinformatics Workshop for Middle School to College.
    Advances in high-throughput techniques have resulted in a rising demand for scientists with basic bioinformatics skills as well as workshops and curricula that teach students bioinformatics concepts. DNA Detective is a workshop we designed to...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology BioinformaticsBioinformatics GeneticsGenetics Plant BiologyPlant Biology

    geneticsbioinformaticsDNAgenotypephenotypegenegene annotation
    Lesson
    7669

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    1462

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    An undergraduate bioinformatics curriculum that teaches eukaryotic gene structure
    Gene structure, transcription, translation, and alternative splicing are challenging concepts for many undergraduates studying biology. These topics are typically covered in a traditional lecture environment, but students often fail to master and...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology BioinformaticsBioinformatics GeneticsGenetics

    bioinformaticsGenome BrowsergenomicsRNAseqsplicingComputer ModelGene Structure
    Lesson
    2285

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    278

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    Discovering Prokaryotic Gene Regulation by Building and Investigating a Computational Model of the lac Operon
    The ability to construct and reason through a biological system is an important skill to develop in science education. This level of understanding forces students to recognize the interrelatedness of components within a biological process and...

    Courses: Introductory BiologyIntroductory Biology

    prokaryotesgene regulationLac Operoninducible operon
    Lesson
    4109

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    596

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    Splicing it Together: Using Primary Data to Explore RNA Splicing and Gene Expression in Large-Lecture Introductory Biology
    At the heart of scientific ways of knowing is the systematic collection and analysis of data, which is then used to propose an explanation of how the world works. In this two-day module, students in a large-lecture course are immersed in a...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Cell BiologyCell Biology GeneticsGenetics Introductory BiologyIntroductory Biology

    gene regulationtranscriptiongene expressioncentral dogmarepressoralternative splicingmRNA processingActivatorTranscription factors
    Lesson
    3406

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    285

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    Garden Variety Mutations: Using Primary Data to Understand the Central Dogma in Large-Lecture Introductory Biology
    The ability to interpret and create an argument from data is a crucial skill for budding scientists, yet one that is seldom practiced in introductory courses. During this argumentation module, students in a large lecture class will work in groups...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology GeneticsGenetics Introductory BiologyIntroductory Biology

    mutationtranscriptiongene expressioncentral dogmatranslationgel electrophoresisGenotype/Phenotype
    Lesson
    4239

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    408

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    Discovering Prokaryotic Gene Regulation with Simulations of the trp Operon
    The trp operon exemplifies important biological concepts, including the central dogma of molecular biology, feedback inhibition, and gene regulation. For this reason, regulation of the trp operon is a common theme in introductory biology,...

    Courses: GeneticsGenetics Introductory BiologyIntroductory Biology MicrobiologyMicrobiology

    prokaryotesgene regulationattenuationfeedback inhibitionrepressible operontrp operon
    Lesson
    3882

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    209

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    Isolation and Functional Analysis of a Pancreatic Enzyme in an Introductory Student Lab
    Structure and function are correlated at all levels of biology. This topic is typically addressed early in an undergraduate class in general or molecular biology before students have gained much skill or knowledge in molecular biology. However, an...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Introductory BiologyIntroductory Biology

    Protein StructureproteaseEnzymechemical bondscatalysissolubility
    Lesson
    4841

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    1206

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    Teaching the Central Dogma Using a Case Study of Genetic Variation in Cystic Fibrosis
    The central dogma of biology is a foundational concept that is traditionally included in genetics curricula at all academic levels. Despite its ubiquitous presence throughout genetics education, students persistently struggle with both the...

    Courses: GeneticsGenetics

    transcriptioncentral dogmatranslationsequence analysisDNA replicationgenetic variants
    Science Behind the Lesson
    656

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    58

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    X-ploring Fragile X: The Science Behind the Syndrome
    Fragile X Syndrome is an X-linked genetic disorder resulting from the impairment of transcription of the FMR1 gene, producing less to no FMRP protein. FMRP is a translational inhibitor that plays a key role in neurological development. Recent...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology GeneticsGenetics Introductory BiologyIntroductory Biology

    epigeneticsgene regulationtranscriptioncentral dogmatranslationFragile X syndromeSphingosine Metabolism
    Teaching Tools and Strategies
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    1718

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    A 360˚ View of COVID-19
    In March 2020, institutions underwent a massive transition to distance learning as a result of the COVID-19 pandemic. With so little time to devise new materials to maximize learning in the new virtual environment, instructors devised a variety of...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology BioinformaticsBioinformatics Cell BiologyCell Biology EvolutionEvolution GeneticsGenetics ImmunologyImmunology Introductory BiologyIntroductory Biology MicrobiologyMicrobiology Science Process SkillsScience Process Skills

    geneticsImmunologyBiochemistrybioinformaticsmolecular evolutionpublic healthvirusCOVID19
    Lesson
    996

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    137

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    Student-Generated Analogies for Learning about Information Flow
    Using analogies is a standard practice for both teaching and communicating ideas in science. Here we upend the traditional lesson, where the instructor provides a fully constructed analogy and explains it, by having the students develop a complex...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology Cell BiologyCell Biology GeneticsGenetics Introductory BiologyIntroductory Biology

    critical thinkingcentral dogmaanalogical reasoning
    Lesson
    2229

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    445

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    Metastatic Mastery: A Case and Game-Based Approach to Learning About Cancer Mechanisms
    Mechanisms that contribute to the development of cancer are numerous and complicated, though most can be traced to a set of mutations in cell cycle regulatory genes that throw the process of cell division off balance. Communication of these...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology GeneticsGenetics Introductory BiologyIntroductory Biology

    mutationcancertranscriptioncell cycletranslationOncogenesTumor-suppressorp53Transcription factor
    Lesson
    3762

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    285

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    Fragile States: A Case Study Exploring Genetics, Molecular Biology, and Biochemistry Through the Lens of Fragile X Syndrome
    This case aims to strengthen students’ understanding of molecular biology concepts through study of Fragile X Syndrome (FXS). Students begin by learning the cause and phenotypes of FXS and related conditions. Students then apply genetics...

    Courses: Biochemistry and Molecular BiologyBiochemistry and Molecular Biology GeneticsGenetics

    gene regulationtranscriptiontranslationFragile X syndrometriplet repeat expansionsex linkagemetabolic pathway